Comparison of live birth rate and fetal outcomes between fresh embryo and frozen-thawed embryo transfers: a prospective study
Abstract Background The study aimed to compare the pregnancy, prenatal, and postnatal outcomes between fresh and frozen embryo transfer (ET) in intracytoplasmic sperm injection (ICSI) cycles at Al-Zahra Referral Women’s Hospital in northwest Iran. Methods A prospective study was conducted among all...
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| Format: | Article |
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BMC
2025-02-01
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| Series: | BMC Pregnancy and Childbirth |
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| Online Access: | https://doi.org/10.1186/s12884-025-07247-2 |
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| author | Seyedeh Farinaz Fattahpour Parvin Hakimi Fatemeh Tabatabaei Mahsa Hejazad Maryam Amoozadeh Leila Sadeghi Negin Rezaie Razih Vejdani Hosein Azizi |
| author_facet | Seyedeh Farinaz Fattahpour Parvin Hakimi Fatemeh Tabatabaei Mahsa Hejazad Maryam Amoozadeh Leila Sadeghi Negin Rezaie Razih Vejdani Hosein Azizi |
| author_sort | Seyedeh Farinaz Fattahpour |
| collection | DOAJ |
| description | Abstract Background The study aimed to compare the pregnancy, prenatal, and postnatal outcomes between fresh and frozen embryo transfer (ET) in intracytoplasmic sperm injection (ICSI) cycles at Al-Zahra Referral Women’s Hospital in northwest Iran. Methods A prospective study was conducted among all infertile women (N = 469) who underwent embryo transfer between 2018 and 23 at Al-Zahra referral infertility center. Patients in cycles with fresh embryo transfer and patients for whom frozen embryos were transferred were compared in terms of live birth rate and fetal outcomes. Multiple logistic regression analysis was used to estimate adjusted odds ratios (AORs) with 95% confidence intervals (CIs). Results The majority of the participants were primary infertility 83.3%. The rate of chemical and clinical pregnancy was (21.8% vs. 17.2%) and (19% vs. 13.4%) in the fresh embryo and the frozen embryo transfers, respectively. Likewise, the rate of live births was (14.1% vs. 9.1%), respectively. The number of retrieved oocytes was significantly higher in frozen ET compared to fresh ET (P = 0.001). In the final analysis, after adjusting for potential confounders, no significant associations were found for clinical pregnancy (AOR = 1.51; 95% CI: 0.90–2.5; P = 0.125) and chemical pregnancy (AOR = 1.31; 95% CI: 0.81–2.3; P = 0.238) rates between fresh and frozen ETs. Similarly, there were no significant differences in live birth rate (AOR = 1.6; 95% CI: 0.54–12.4), preterm birth (AOR = 0.62; 95% CI: 0.33–5.5), and primary infertility (AOR = 0.73; 95% CI: 0.34–1.6) between fresh and frozen ETs. The incidence of multiple pregnancies and spontaneous abortion was (5% vs. 13.8%) and (22.2% vs. 30.2%) in the fresh embryo and frozen embryo groups, respectively. Conclusion No significant differences in perinatal and postnatal outcomes were found between fresh and frozen embryo transfers. |
| format | Article |
| id | doaj-art-00a0394f95c6481baa86e12dc07adeeb |
| institution | Kabale University |
| issn | 1471-2393 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | BMC |
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| series | BMC Pregnancy and Childbirth |
| spelling | doaj-art-00a0394f95c6481baa86e12dc07adeeb2025-02-09T12:59:14ZengBMCBMC Pregnancy and Childbirth1471-23932025-02-012511810.1186/s12884-025-07247-2Comparison of live birth rate and fetal outcomes between fresh embryo and frozen-thawed embryo transfers: a prospective studySeyedeh Farinaz Fattahpour0Parvin Hakimi1Fatemeh Tabatabaei2Mahsa Hejazad3Maryam Amoozadeh4Leila Sadeghi5Negin Rezaie6Razih Vejdani7Hosein Azizi8Women’s Reproductive Health Research Center, School of Medicine, Tabriz University of Medical SciencesWomen’s Reproductive Health Research Center, Tabriz University of Medical SciencesWomen’s Reproductive Health Research Center, Tabriz University of Medical SciencesWomen’s Reproductive Health Research Center, School of Medicine, Tabriz University of Medical SciencesWomen’s Reproductive Health Research Center, School of Medicine, Tabriz University of Medical SciencesWomen’s Reproductive Health Research Center, Tabriz University of Medical SciencesWomen’s Reproductive Health Research Center, Tabriz University of Medical SciencesWomen’s Reproductive Health Research Center, Tabriz University of Medical SciencesWomen’s Reproductive Health Research Center, Tabriz University of Medical SciencesAbstract Background The study aimed to compare the pregnancy, prenatal, and postnatal outcomes between fresh and frozen embryo transfer (ET) in intracytoplasmic sperm injection (ICSI) cycles at Al-Zahra Referral Women’s Hospital in northwest Iran. Methods A prospective study was conducted among all infertile women (N = 469) who underwent embryo transfer between 2018 and 23 at Al-Zahra referral infertility center. Patients in cycles with fresh embryo transfer and patients for whom frozen embryos were transferred were compared in terms of live birth rate and fetal outcomes. Multiple logistic regression analysis was used to estimate adjusted odds ratios (AORs) with 95% confidence intervals (CIs). Results The majority of the participants were primary infertility 83.3%. The rate of chemical and clinical pregnancy was (21.8% vs. 17.2%) and (19% vs. 13.4%) in the fresh embryo and the frozen embryo transfers, respectively. Likewise, the rate of live births was (14.1% vs. 9.1%), respectively. The number of retrieved oocytes was significantly higher in frozen ET compared to fresh ET (P = 0.001). In the final analysis, after adjusting for potential confounders, no significant associations were found for clinical pregnancy (AOR = 1.51; 95% CI: 0.90–2.5; P = 0.125) and chemical pregnancy (AOR = 1.31; 95% CI: 0.81–2.3; P = 0.238) rates between fresh and frozen ETs. Similarly, there were no significant differences in live birth rate (AOR = 1.6; 95% CI: 0.54–12.4), preterm birth (AOR = 0.62; 95% CI: 0.33–5.5), and primary infertility (AOR = 0.73; 95% CI: 0.34–1.6) between fresh and frozen ETs. The incidence of multiple pregnancies and spontaneous abortion was (5% vs. 13.8%) and (22.2% vs. 30.2%) in the fresh embryo and frozen embryo groups, respectively. Conclusion No significant differences in perinatal and postnatal outcomes were found between fresh and frozen embryo transfers.https://doi.org/10.1186/s12884-025-07247-2Sperm intracytoplasmic injectionAssisted reproductive technologyInfertilityReproductiveWomen's health |
| spellingShingle | Seyedeh Farinaz Fattahpour Parvin Hakimi Fatemeh Tabatabaei Mahsa Hejazad Maryam Amoozadeh Leila Sadeghi Negin Rezaie Razih Vejdani Hosein Azizi Comparison of live birth rate and fetal outcomes between fresh embryo and frozen-thawed embryo transfers: a prospective study BMC Pregnancy and Childbirth Sperm intracytoplasmic injection Assisted reproductive technology Infertility Reproductive Women's health |
| title | Comparison of live birth rate and fetal outcomes between fresh embryo and frozen-thawed embryo transfers: a prospective study |
| title_full | Comparison of live birth rate and fetal outcomes between fresh embryo and frozen-thawed embryo transfers: a prospective study |
| title_fullStr | Comparison of live birth rate and fetal outcomes between fresh embryo and frozen-thawed embryo transfers: a prospective study |
| title_full_unstemmed | Comparison of live birth rate and fetal outcomes between fresh embryo and frozen-thawed embryo transfers: a prospective study |
| title_short | Comparison of live birth rate and fetal outcomes between fresh embryo and frozen-thawed embryo transfers: a prospective study |
| title_sort | comparison of live birth rate and fetal outcomes between fresh embryo and frozen thawed embryo transfers a prospective study |
| topic | Sperm intracytoplasmic injection Assisted reproductive technology Infertility Reproductive Women's health |
| url | https://doi.org/10.1186/s12884-025-07247-2 |
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