Triglyceride levels and its association with all-cause mortality and cardiovascular outcomes among patients with heart failure
Abstract Remnant cholesterol, identified by triglyceride-rich lipoprotein, is a significant causal risk factor for ischemic heart diseases. The association of triglyceride levels with all-cause and cause-specific outcomes in heart failure (HF) remains unexplored. Using a previously validated territo...
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Nature Portfolio
2025-02-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-025-56790-1 |
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| author | Qing-Wen Ren Tiew-Hwa Katherine Teng Wouter Ouwerkerk Yi-Kei Tse Christopher Tze Wei Tsang Mei-Zhen Wu Hung-Fat Tse Adriaan A. Voors Jasper Tromp Carolyn S. P. Lam Kai-Hang Yiu |
| author_facet | Qing-Wen Ren Tiew-Hwa Katherine Teng Wouter Ouwerkerk Yi-Kei Tse Christopher Tze Wei Tsang Mei-Zhen Wu Hung-Fat Tse Adriaan A. Voors Jasper Tromp Carolyn S. P. Lam Kai-Hang Yiu |
| author_sort | Qing-Wen Ren |
| collection | DOAJ |
| description | Abstract Remnant cholesterol, identified by triglyceride-rich lipoprotein, is a significant causal risk factor for ischemic heart diseases. The association of triglyceride levels with all-cause and cause-specific outcomes in heart failure (HF) remains unexplored. Using a previously validated territory-wide clinical information registry, all eligible patients diagnosed with HF (N = 127124) from 2000 to 2020 were included. In this population-based cohort (mean age: 71.4 ± 12.2 years, 51.8% male), the association between triglyceride levels and risk of all-cause mortality and cardiovascular disease was a U-shapedḍ curve. High triglyceride levels (≥3.0 mmol/L) were associated with atherosclerotic cardiovascular disease admission or death; conversely, lower triglyceride levels (<1.2 mmol/L) were associated with higher risks of HF readmission or death. The risk of adjusted all-cause mortality reached a nadir between triglyceride levels of 1.2 mmol/L and 3.0 mmol/L. Results were externally validated in BIOSTAT-CHF. Our findings have important implications for defining the role of triglyceride levels in contributing to the diverse outcomes in patients with HF. |
| format | Article |
| id | doaj-art-00caa2b668c14a378348ddf35d5344de |
| institution | Kabale University |
| issn | 2041-1723 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Nature Portfolio |
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| series | Nature Communications |
| spelling | doaj-art-00caa2b668c14a378348ddf35d5344de2025-02-09T12:44:51ZengNature PortfolioNature Communications2041-17232025-02-0116111110.1038/s41467-025-56790-1Triglyceride levels and its association with all-cause mortality and cardiovascular outcomes among patients with heart failureQing-Wen Ren0Tiew-Hwa Katherine Teng1Wouter Ouwerkerk2Yi-Kei Tse3Christopher Tze Wei Tsang4Mei-Zhen Wu5Hung-Fat Tse6Adriaan A. Voors7Jasper Tromp8Carolyn S. P. Lam9Kai-Hang Yiu10Cardiology Division, Department of Medicine, The University of Hong Kong Shen Zhen HospitalNational Heart CentreNational Heart CentreCardiology Division, Department of Medicine, The University of Hong Kong, Queen Mary HospitalCardiology Division, Department of Medicine, The University of Hong Kong, Queen Mary HospitalCardiology Division, Department of Medicine, The University of Hong Kong Shen Zhen HospitalCardiology Division, Department of Medicine, The University of Hong Kong Shen Zhen HospitalUniversity Medical Centre Groningen, Department of CardiologyNational Heart CentreNational Heart CentreCardiology Division, Department of Medicine, The University of Hong Kong Shen Zhen HospitalAbstract Remnant cholesterol, identified by triglyceride-rich lipoprotein, is a significant causal risk factor for ischemic heart diseases. The association of triglyceride levels with all-cause and cause-specific outcomes in heart failure (HF) remains unexplored. Using a previously validated territory-wide clinical information registry, all eligible patients diagnosed with HF (N = 127124) from 2000 to 2020 were included. In this population-based cohort (mean age: 71.4 ± 12.2 years, 51.8% male), the association between triglyceride levels and risk of all-cause mortality and cardiovascular disease was a U-shapedḍ curve. High triglyceride levels (≥3.0 mmol/L) were associated with atherosclerotic cardiovascular disease admission or death; conversely, lower triglyceride levels (<1.2 mmol/L) were associated with higher risks of HF readmission or death. The risk of adjusted all-cause mortality reached a nadir between triglyceride levels of 1.2 mmol/L and 3.0 mmol/L. Results were externally validated in BIOSTAT-CHF. Our findings have important implications for defining the role of triglyceride levels in contributing to the diverse outcomes in patients with HF.https://doi.org/10.1038/s41467-025-56790-1 |
| spellingShingle | Qing-Wen Ren Tiew-Hwa Katherine Teng Wouter Ouwerkerk Yi-Kei Tse Christopher Tze Wei Tsang Mei-Zhen Wu Hung-Fat Tse Adriaan A. Voors Jasper Tromp Carolyn S. P. Lam Kai-Hang Yiu Triglyceride levels and its association with all-cause mortality and cardiovascular outcomes among patients with heart failure Nature Communications |
| title | Triglyceride levels and its association with all-cause mortality and cardiovascular outcomes among patients with heart failure |
| title_full | Triglyceride levels and its association with all-cause mortality and cardiovascular outcomes among patients with heart failure |
| title_fullStr | Triglyceride levels and its association with all-cause mortality and cardiovascular outcomes among patients with heart failure |
| title_full_unstemmed | Triglyceride levels and its association with all-cause mortality and cardiovascular outcomes among patients with heart failure |
| title_short | Triglyceride levels and its association with all-cause mortality and cardiovascular outcomes among patients with heart failure |
| title_sort | triglyceride levels and its association with all cause mortality and cardiovascular outcomes among patients with heart failure |
| url | https://doi.org/10.1038/s41467-025-56790-1 |
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