Association between PM2.5 components and poor ovarian response in assisted reproductive technology patients: A retrospective cohort study identifying sensitive exposure windows in China
Environmental factors, particularly various components of fine particulate matter (PM2.5) (i.e., sulfate [SO42-], nitrate [NO3-], ammonium [NH4+], organic matter [OM] and black carbon [BC]), are increasingly recognized as potential risk factors for poor ovarian response (POR) in fertility treatments...
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Elsevier
2025-02-01
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| Series: | Environment International |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0160412025000728 |
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| author | Rui-Ling Liu Zhi-Lei Xu Yu-Ling Hu Xing-Yu Lv Quan-Zi Yao Jia-Liang He Li-Juan Fu Li-Hong Geng Tong Wang Zhao-Hui Zhong Yi-Jian Zhu Yu-Bin Ding |
| author_facet | Rui-Ling Liu Zhi-Lei Xu Yu-Ling Hu Xing-Yu Lv Quan-Zi Yao Jia-Liang He Li-Juan Fu Li-Hong Geng Tong Wang Zhao-Hui Zhong Yi-Jian Zhu Yu-Bin Ding |
| author_sort | Rui-Ling Liu |
| collection | DOAJ |
| description | Environmental factors, particularly various components of fine particulate matter (PM2.5) (i.e., sulfate [SO42-], nitrate [NO3-], ammonium [NH4+], organic matter [OM] and black carbon [BC]), are increasingly recognized as potential risk factors for poor ovarian response (POR) in fertility treatments. However, existing research is limited, and the critical periods of vulnerability to exposure to PM2.5 and its components remain unclear. In this retrospective cohort study, we included 38,619 patients undergoing their first in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) treatment, defining POR as the primary outcome based on the POSEIDON criteria. We divided the six months prior to oocyte pick up (OPU) into different exposure windows and used logistic regression models to assess the association between pollutants and POR. Results showed that exposure to PM2.5 and its components in the three months before OPU significantly increased the odds of POR. The distributed lag nonlinear model (DLNM) analysis revealed the lagged effects of PM2.5 component exposure, particularly during lag weeks 2–5, where exposure was significantly associated with the occurrence of POR. This period may represent a sensitive window for exposure. Meanwhile, the restricted cubic spline (RCS) analysis indicated that the odds of POR gradually increased with higher pollutant concentrations. These findings underscore the urgent need for public health measures during sensitive stages of follicular development, particularly policies aimed at reducing environmental pollutant exposure among women of reproductive age to protect reproductive health. |
| format | Article |
| id | doaj-art-00ddad16a3754b36a25a57da53162b13 |
| institution | Kabale University |
| issn | 0160-4120 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Environment International |
| spelling | doaj-art-00ddad16a3754b36a25a57da53162b132025-02-08T04:59:23ZengElsevierEnvironment International0160-41202025-02-01196109321Association between PM2.5 components and poor ovarian response in assisted reproductive technology patients: A retrospective cohort study identifying sensitive exposure windows in ChinaRui-Ling Liu0Zhi-Lei Xu1Yu-Ling Hu2Xing-Yu Lv3Quan-Zi Yao4Jia-Liang He5Li-Juan Fu6Li-Hong Geng7Tong Wang8Zhao-Hui Zhong9Yi-Jian Zhu10Yu-Bin Ding11Department of Obstetrics and Gynecology, Women and Children’s Hospital of Chongqing Medical University, Chongqing 401147, China; Department of Epidemiology, Joint International Research Laboratory of Reproduction and Development of the Ministry of Education of China, School of Public Health, Chongqing Medical University, Chongqing 400016, ChinaDepartment of Obstetrics and Gynecology, Women and Children’s Hospital of Chongqing Medical University, Chongqing 401147, China; Department of Epidemiology, Joint International Research Laboratory of Reproduction and Development of the Ministry of Education of China, School of Public Health, Chongqing Medical University, Chongqing 400016, ChinaThe Reproductive Center, Sichuan Jinxin Xinan Women & Children’s Hospital, Chengdu, 610011 Sichuan, ChinaThe Reproductive Center, Sichuan Jinxin Xinan Women & Children’s Hospital, Chengdu, 610011 Sichuan, ChinaDepartment of Obstetrics and Gynecology, Women and Children’s Hospital of Chongqing Medical University, Chongqing 401147, China; Department of Epidemiology, Joint International Research Laboratory of Reproduction and Development of the Ministry of Education of China, School of Public Health, Chongqing Medical University, Chongqing 400016, ChinaDepartment of Obstetrics and Gynecology, Women and Children’s Hospital of Chongqing Medical University, Chongqing 401147, ChinaDepartment of Epidemiology, Joint International Research Laboratory of Reproduction and Development of the Ministry of Education of China, School of Public Health, Chongqing Medical University, Chongqing 400016, China; Department of Pharmacology, Academician Workstation, Changsha Medical University, Changsha 410219, ChinaThe Reproductive Center, Sichuan Jinxin Xinan Women & Children’s Hospital, Chengdu, 610011 Sichuan, ChinaKey Lab of Medical Protection for Electromagnetic Radiation, Ministry of Education of China, Institute of Toxicology, College of Preventive Medicine, Third Military Medical University (Army Medical University), Chongqing 400038, ChinaDepartment of Epidemiology, Joint International Research Laboratory of Reproduction and Development of the Ministry of Education of China, School of Public Health, Chongqing Medical University, Chongqing 400016, China; Corresponding author at: Department of Epidemiology, Joint International Research Laboratory of Reproduction and Development of the Ministry of Education of China, School of Public Health, Chongqing Medical University, No.1 Yixueyuan Rd. Yuzhong District, Chongqing 400016, China.NHC Key Laboratory of Birth Defects and Reproductive Health, Chongqing Population and Family Planning Science and Technology Research Institute, Chongqing 404100, China; Corresponding author at: NHC Key Laboratory of Birth Defects and Reproductive Health, Chongqing Population and Family Planning Science and Technology Research Institute, No.420, Baohuan Rd, Chongqing 400100, China.Department of Obstetrics and Gynecology, Women and Children’s Hospital of Chongqing Medical University, Chongqing 401147, China; Department of Epidemiology, Joint International Research Laboratory of Reproduction and Development of the Ministry of Education of China, School of Public Health, Chongqing Medical University, Chongqing 400016, China; Department of Pharmacology, Academician Workstation, Changsha Medical University, Changsha 410219, China; Corresponding author at: Department of Obstetrics and Gynecology, Women and Children’s Hospital of Chongqing Medical University, No.120, Longshan Rd, Chongqing, China. No.1501 Leifeng Rd, Wangcheng District, Changsha, 410219, Hunan, China.Environmental factors, particularly various components of fine particulate matter (PM2.5) (i.e., sulfate [SO42-], nitrate [NO3-], ammonium [NH4+], organic matter [OM] and black carbon [BC]), are increasingly recognized as potential risk factors for poor ovarian response (POR) in fertility treatments. However, existing research is limited, and the critical periods of vulnerability to exposure to PM2.5 and its components remain unclear. In this retrospective cohort study, we included 38,619 patients undergoing their first in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) treatment, defining POR as the primary outcome based on the POSEIDON criteria. We divided the six months prior to oocyte pick up (OPU) into different exposure windows and used logistic regression models to assess the association between pollutants and POR. Results showed that exposure to PM2.5 and its components in the three months before OPU significantly increased the odds of POR. The distributed lag nonlinear model (DLNM) analysis revealed the lagged effects of PM2.5 component exposure, particularly during lag weeks 2–5, where exposure was significantly associated with the occurrence of POR. This period may represent a sensitive window for exposure. Meanwhile, the restricted cubic spline (RCS) analysis indicated that the odds of POR gradually increased with higher pollutant concentrations. These findings underscore the urgent need for public health measures during sensitive stages of follicular development, particularly policies aimed at reducing environmental pollutant exposure among women of reproductive age to protect reproductive health.http://www.sciencedirect.com/science/article/pii/S0160412025000728Poor ovarian responseAssisted reproductive technologyPOSEIDON criteriaFine particulate matterPM2.5 componentsExposure window |
| spellingShingle | Rui-Ling Liu Zhi-Lei Xu Yu-Ling Hu Xing-Yu Lv Quan-Zi Yao Jia-Liang He Li-Juan Fu Li-Hong Geng Tong Wang Zhao-Hui Zhong Yi-Jian Zhu Yu-Bin Ding Association between PM2.5 components and poor ovarian response in assisted reproductive technology patients: A retrospective cohort study identifying sensitive exposure windows in China Environment International Poor ovarian response Assisted reproductive technology POSEIDON criteria Fine particulate matter PM2.5 components Exposure window |
| title | Association between PM2.5 components and poor ovarian response in assisted reproductive technology patients: A retrospective cohort study identifying sensitive exposure windows in China |
| title_full | Association between PM2.5 components and poor ovarian response in assisted reproductive technology patients: A retrospective cohort study identifying sensitive exposure windows in China |
| title_fullStr | Association between PM2.5 components and poor ovarian response in assisted reproductive technology patients: A retrospective cohort study identifying sensitive exposure windows in China |
| title_full_unstemmed | Association between PM2.5 components and poor ovarian response in assisted reproductive technology patients: A retrospective cohort study identifying sensitive exposure windows in China |
| title_short | Association between PM2.5 components and poor ovarian response in assisted reproductive technology patients: A retrospective cohort study identifying sensitive exposure windows in China |
| title_sort | association between pm2 5 components and poor ovarian response in assisted reproductive technology patients a retrospective cohort study identifying sensitive exposure windows in china |
| topic | Poor ovarian response Assisted reproductive technology POSEIDON criteria Fine particulate matter PM2.5 components Exposure window |
| url | http://www.sciencedirect.com/science/article/pii/S0160412025000728 |
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