The Role of Gut Microbiota in Hypertension Management - A Review
Introduction and purpose: Hypertension, or high blood pressure, is a condition characterized by persistently elevated arterial pressure, leading to severe complications such as heart disease, stroke, and kidney failure. According to the World Health Organization (WHO), hypertension affects approxim...
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| Language: | English |
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Nicolaus Copernicus University in Toruń
2025-02-01
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| Series: | Quality in Sport |
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| Online Access: | https://apcz.umk.pl/QS/article/view/57655 |
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| author | Alicja Kot Marta Wojtczak Natalia Myśliwiec Adrian Różycki Michał Pniak Paweł Miklis Maciej Mawlichanów Aleksandra Ciesielska Aleksandra Sieradzka Krzysztof Szerej |
| author_facet | Alicja Kot Marta Wojtczak Natalia Myśliwiec Adrian Różycki Michał Pniak Paweł Miklis Maciej Mawlichanów Aleksandra Ciesielska Aleksandra Sieradzka Krzysztof Szerej |
| author_sort | Alicja Kot |
| collection | DOAJ |
| description |
Introduction and purpose: Hypertension, or high blood pressure, is a condition characterized by persistently elevated
arterial pressure, leading to severe complications such as heart disease, stroke, and kidney
failure. According to the World Health Organization (WHO), hypertension affects
approximately 1.13 billion people worldwide, contributing significantly to global morbidity
and mortality. Emerging research has revealed a significant connection between gut
microbiota—the diverse community of microorganisms residing in the gastrointestinal
tract—and the regulation of blood pressure. This comprehensive review explores the intricate
relationship between gut microbiota and hypertension, delving into the underlying
mechanisms, evidence from animal and human studies, and potential therapeutic
interventions.
The state of knowledge: Key mechanisms involved into regulation of blood pressure include the production of short-
chain fatty acids (SCFAs), modulation of the renin-angiotensin system (RAS), immune system regulation, and metabolite production such as trimethylamine-N-oxide (TMAO). Animal studies using fecal microbiota transplantation (FMT) have provided strong evidence
for a causal role of gut microbiota in blood pressure regulation. Human studies have shown
associations between gut microbiota composition and hypertension, highlighting the potential
for dietary interventions, probiotics, prebiotics, physical activity and FMT as therapeutic
strategies.
Summary: This review underscores the promise of microbiota-targeted therapies in managing
hypertension and calls for further research to elucidate precise mechanisms and develop
personalized medicine approaches. Understanding the complex interactions between gut
microbiota and hypertension could pave the way for innovative treatments and improved
cardiovascular health outcomes.
|
| format | Article |
| id | doaj-art-0134bbbe7e2e43ee890540049267c035 |
| institution | Kabale University |
| issn | 2450-3118 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Nicolaus Copernicus University in Toruń |
| record_format | Article |
| series | Quality in Sport |
| spelling | doaj-art-0134bbbe7e2e43ee890540049267c0352025-02-12T08:26:26ZengNicolaus Copernicus University in ToruńQuality in Sport2450-31182025-02-013810.12775/QS.2025.38.57655The Role of Gut Microbiota in Hypertension Management - A ReviewAlicja Kot0https://orcid.org/0009-0001-2999-6775Marta Wojtczak1https://orcid.org/0009-0007-0032-7520Natalia Myśliwiec2https://orcid.org/0000-0002-4359-9899Adrian Różycki3https://orcid.org/0000-0002-9110-5443Michał Pniak4https://orcid.org/0009-0006-2982-6078Paweł Miklis5https://orcid.org/0009-0008-4578-233XMaciej Mawlichanów6https://orcid.org/0000-0002-6543-8105Aleksandra Ciesielska7https://orcid.org/0009-0000-5015-6140Aleksandra Sieradzka8https://orcid.org/0009-0004-2281-7617Krzysztof Szerej9https://orcid.org/0009-0003-7581-4965Medical Univeristy of Warsaw, Żwirki i Wigury 61, 02-901 Warsaw, PolandCounty Health Center in Otwock Sp. z o.o. Otwock, PolandNational Medicine Institute of the Ministry of the Interior and Administration, Wołoska 137, 02-507 Warsaw, PolandMedica Plus Family Clinic Sp. z o. o., Gdańsk, PolandJohn Paul II Memorial Masovia Provincial Hospital in Siedlce, PolandUniversity Clinical Center of the Medical University of Warsaw, PolandMilitary Institute of Medicine, Warsaw PolandMazovian Rehabilitation Center "STOCER" Sp. z o.o. Railway Hospital in Pruszków: Pruszków, PLMedical Univeristy of Warsaw, Żwirki i Wigury 61, 02-901 Warsaw, PolandDistrict Hospital in Sochaczew, Batalionów Chłopskich 3/7, Sochaczew, Poland, Introduction and purpose: Hypertension, or high blood pressure, is a condition characterized by persistently elevated arterial pressure, leading to severe complications such as heart disease, stroke, and kidney failure. According to the World Health Organization (WHO), hypertension affects approximately 1.13 billion people worldwide, contributing significantly to global morbidity and mortality. Emerging research has revealed a significant connection between gut microbiota—the diverse community of microorganisms residing in the gastrointestinal tract—and the regulation of blood pressure. This comprehensive review explores the intricate relationship between gut microbiota and hypertension, delving into the underlying mechanisms, evidence from animal and human studies, and potential therapeutic interventions. The state of knowledge: Key mechanisms involved into regulation of blood pressure include the production of short- chain fatty acids (SCFAs), modulation of the renin-angiotensin system (RAS), immune system regulation, and metabolite production such as trimethylamine-N-oxide (TMAO). Animal studies using fecal microbiota transplantation (FMT) have provided strong evidence for a causal role of gut microbiota in blood pressure regulation. Human studies have shown associations between gut microbiota composition and hypertension, highlighting the potential for dietary interventions, probiotics, prebiotics, physical activity and FMT as therapeutic strategies. Summary: This review underscores the promise of microbiota-targeted therapies in managing hypertension and calls for further research to elucidate precise mechanisms and develop personalized medicine approaches. Understanding the complex interactions between gut microbiota and hypertension could pave the way for innovative treatments and improved cardiovascular health outcomes. https://apcz.umk.pl/QS/article/view/57655hypertensiongut microbiotashort chain fatty acidsfecal microbiota transplantationprobioticstrimethylamine-N-oxide |
| spellingShingle | Alicja Kot Marta Wojtczak Natalia Myśliwiec Adrian Różycki Michał Pniak Paweł Miklis Maciej Mawlichanów Aleksandra Ciesielska Aleksandra Sieradzka Krzysztof Szerej The Role of Gut Microbiota in Hypertension Management - A Review Quality in Sport hypertension gut microbiota short chain fatty acids fecal microbiota transplantation probiotics trimethylamine-N-oxide |
| title | The Role of Gut Microbiota in Hypertension Management - A Review |
| title_full | The Role of Gut Microbiota in Hypertension Management - A Review |
| title_fullStr | The Role of Gut Microbiota in Hypertension Management - A Review |
| title_full_unstemmed | The Role of Gut Microbiota in Hypertension Management - A Review |
| title_short | The Role of Gut Microbiota in Hypertension Management - A Review |
| title_sort | role of gut microbiota in hypertension management a review |
| topic | hypertension gut microbiota short chain fatty acids fecal microbiota transplantation probiotics trimethylamine-N-oxide |
| url | https://apcz.umk.pl/QS/article/view/57655 |
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