Metabolomics profiling reveals p-aminobenzoic acid enhances resistance to Fusarium head blight in wheat
Abstract Fusarium head blight (FHB) not only causes severe yield losses but also mycotoxin contamination in wheat, posing a serious threat to food security and public health. The mechanisms of resistance to FHB in wheat are critical for effective prevention and control of the pathogen. In this resea...
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-02-01
|
| Series: | Food Production, Processing and Nutrition |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s43014-024-00291-z |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1823861695392514048 |
|---|---|
| author | Yiluo Tan Kangjun Wang Mingming Guo Guangxu Zhang Xiaofeng Li Yijun Shi Maosheng He Dayong Xu Feng Chen Jiwei Fan |
| author_facet | Yiluo Tan Kangjun Wang Mingming Guo Guangxu Zhang Xiaofeng Li Yijun Shi Maosheng He Dayong Xu Feng Chen Jiwei Fan |
| author_sort | Yiluo Tan |
| collection | DOAJ |
| description | Abstract Fusarium head blight (FHB) not only causes severe yield losses but also mycotoxin contamination in wheat, posing a serious threat to food security and public health. The mechanisms of resistance to FHB in wheat are critical for effective prevention and control of the pathogen. In this research, we investigated and analyzed the metabolite changes induced by FHB colonization in the FHB-resistant cultivar Lianmai12 through Fusarium graminearum inoculation and mock inoculation. A total of 1001 metabolites were detected, 109 of which were significantly changed due to FHB infection. The majority of these 109 metabolites belonged to alkaloids, flavonoids, phenolic acids, lipids and organic acids. The most enriched KEGG pathways were plant hormone signal transduction and phenylpropanoid biosynthesis, which may constitute the major defence responses to FHB challenge. The metabolite p-aminobenzoic acid (PABA) significantly suppressed the growth of mycelia and the production of conidia in vitro. Further studies revealed that spraying PABA at early anthesis on wheat spikes reduced the development of FHB disease. These results provide preliminary insights into the metabolic basis of resistance in Lianmai12 and will be beneficial in the development of potential biocontrol agents against FHB. Graphical Abstract |
| format | Article |
| id | doaj-art-034f401c8ae5454887738cf0f0af7276 |
| institution | Kabale University |
| issn | 2661-8974 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Food Production, Processing and Nutrition |
| spelling | doaj-art-034f401c8ae5454887738cf0f0af72762025-02-09T12:47:47ZengBMCFood Production, Processing and Nutrition2661-89742025-02-017111610.1186/s43014-024-00291-zMetabolomics profiling reveals p-aminobenzoic acid enhances resistance to Fusarium head blight in wheatYiluo Tan0Kangjun Wang1Mingming Guo2Guangxu Zhang3Xiaofeng Li4Yijun Shi5Maosheng He6Dayong Xu7Feng Chen8Jiwei Fan9Lianyungang Academy of Agricultural ScienceLianyungang Academy of Agricultural ScienceLianyungang Academy of Agricultural ScienceLianyungang Academy of Agricultural ScienceLianyungang Academy of Agricultural ScienceLianyungang Academy of Agricultural ScienceLianyungang Academy of Agricultural ScienceLianyungang Academy of Agricultural ScienceLianyungang Academy of Agricultural ScienceLianyungang Academy of Agricultural ScienceAbstract Fusarium head blight (FHB) not only causes severe yield losses but also mycotoxin contamination in wheat, posing a serious threat to food security and public health. The mechanisms of resistance to FHB in wheat are critical for effective prevention and control of the pathogen. In this research, we investigated and analyzed the metabolite changes induced by FHB colonization in the FHB-resistant cultivar Lianmai12 through Fusarium graminearum inoculation and mock inoculation. A total of 1001 metabolites were detected, 109 of which were significantly changed due to FHB infection. The majority of these 109 metabolites belonged to alkaloids, flavonoids, phenolic acids, lipids and organic acids. The most enriched KEGG pathways were plant hormone signal transduction and phenylpropanoid biosynthesis, which may constitute the major defence responses to FHB challenge. The metabolite p-aminobenzoic acid (PABA) significantly suppressed the growth of mycelia and the production of conidia in vitro. Further studies revealed that spraying PABA at early anthesis on wheat spikes reduced the development of FHB disease. These results provide preliminary insights into the metabolic basis of resistance in Lianmai12 and will be beneficial in the development of potential biocontrol agents against FHB. Graphical Abstracthttps://doi.org/10.1186/s43014-024-00291-zWheatFusarium head blightp-aminobenzoic acidMetabolomics |
| spellingShingle | Yiluo Tan Kangjun Wang Mingming Guo Guangxu Zhang Xiaofeng Li Yijun Shi Maosheng He Dayong Xu Feng Chen Jiwei Fan Metabolomics profiling reveals p-aminobenzoic acid enhances resistance to Fusarium head blight in wheat Food Production, Processing and Nutrition Wheat Fusarium head blight p-aminobenzoic acid Metabolomics |
| title | Metabolomics profiling reveals p-aminobenzoic acid enhances resistance to Fusarium head blight in wheat |
| title_full | Metabolomics profiling reveals p-aminobenzoic acid enhances resistance to Fusarium head blight in wheat |
| title_fullStr | Metabolomics profiling reveals p-aminobenzoic acid enhances resistance to Fusarium head blight in wheat |
| title_full_unstemmed | Metabolomics profiling reveals p-aminobenzoic acid enhances resistance to Fusarium head blight in wheat |
| title_short | Metabolomics profiling reveals p-aminobenzoic acid enhances resistance to Fusarium head blight in wheat |
| title_sort | metabolomics profiling reveals p aminobenzoic acid enhances resistance to fusarium head blight in wheat |
| topic | Wheat Fusarium head blight p-aminobenzoic acid Metabolomics |
| url | https://doi.org/10.1186/s43014-024-00291-z |
| work_keys_str_mv | AT yiluotan metabolomicsprofilingrevealspaminobenzoicacidenhancesresistancetofusariumheadblightinwheat AT kangjunwang metabolomicsprofilingrevealspaminobenzoicacidenhancesresistancetofusariumheadblightinwheat AT mingmingguo metabolomicsprofilingrevealspaminobenzoicacidenhancesresistancetofusariumheadblightinwheat AT guangxuzhang metabolomicsprofilingrevealspaminobenzoicacidenhancesresistancetofusariumheadblightinwheat AT xiaofengli metabolomicsprofilingrevealspaminobenzoicacidenhancesresistancetofusariumheadblightinwheat AT yijunshi metabolomicsprofilingrevealspaminobenzoicacidenhancesresistancetofusariumheadblightinwheat AT maoshenghe metabolomicsprofilingrevealspaminobenzoicacidenhancesresistancetofusariumheadblightinwheat AT dayongxu metabolomicsprofilingrevealspaminobenzoicacidenhancesresistancetofusariumheadblightinwheat AT fengchen metabolomicsprofilingrevealspaminobenzoicacidenhancesresistancetofusariumheadblightinwheat AT jiweifan metabolomicsprofilingrevealspaminobenzoicacidenhancesresistancetofusariumheadblightinwheat |