Autism spectrum disorder common variants associated with regional lobe volume variations at birth: cross-sectional study in 273 European term neonates in developing human connectome project
Abstract Increasing lines of evidence suggest cerebral overgrowth in autism spectrum disorder (ASD) children in early life, but few studies have examined the effect of ASD common genetic variants on brain volumes in a general paediatric population. This study examined the association between ASD pol...
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2025-02-01
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| Series: | Translational Psychiatry |
| Online Access: | https://doi.org/10.1038/s41398-025-03253-2 |
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| author | Hai Le Daphna Fenchel Konstantina Dimitrakopoulou Hamel Patel Charles Curtis Lucilio Cordero-Grande A. David Edwards Joseph Hajnal Jacques-Donald Tournier Maria Deprez Harriet Cullen |
| author_facet | Hai Le Daphna Fenchel Konstantina Dimitrakopoulou Hamel Patel Charles Curtis Lucilio Cordero-Grande A. David Edwards Joseph Hajnal Jacques-Donald Tournier Maria Deprez Harriet Cullen |
| author_sort | Hai Le |
| collection | DOAJ |
| description | Abstract Increasing lines of evidence suggest cerebral overgrowth in autism spectrum disorder (ASD) children in early life, but few studies have examined the effect of ASD common genetic variants on brain volumes in a general paediatric population. This study examined the association between ASD polygenic risk score (PRS) and volumes of the frontal, temporal, parietal, occipital, fronto-temporal and parieto-occipital lobes in 273 term-born infants of European ancestry in the developing Human Connectome Project. ASD PRS was positively associated with frontal (β = 0.027, p FDR = 0.04) and fronto-temporal (β = 0.024, p FDR = 0.01) volumes, but negatively with parietal (β = −0.037, p FDR = 0.04) and parieto-occipital (β = −0.033, p FDR = 0.01) volumes. This preliminary result suggests the potential involvement of ASD common genetic variants in early structural variations linked to ASD. |
| format | Article |
| id | doaj-art-0412ec3b919841bd9f7efd7e52ad88e6 |
| institution | Kabale University |
| issn | 2158-3188 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Translational Psychiatry |
| spelling | doaj-art-0412ec3b919841bd9f7efd7e52ad88e62025-02-09T12:55:32ZengNature Publishing GroupTranslational Psychiatry2158-31882025-02-011511810.1038/s41398-025-03253-2Autism spectrum disorder common variants associated with regional lobe volume variations at birth: cross-sectional study in 273 European term neonates in developing human connectome projectHai Le0Daphna Fenchel1Konstantina Dimitrakopoulou2Hamel Patel3Charles Curtis4Lucilio Cordero-Grande5A. David Edwards6Joseph Hajnal7Jacques-Donald Tournier8Maria Deprez9Harriet Cullen10Research Department of Early Life Imaging, School of Biomedical Engineering and Imaging Sciences, King’s College LondonResearch Department of Early Life Imaging, School of Biomedical Engineering and Imaging Sciences, King’s College LondonTranslational Bioinformatics Platform, NIHR Biomedical Research Centre, Guy’s and St. Thomas’ NHS Foundation Trust and King’s College LondonNIHR BioResource Centre Maudsley, NIHR Maudsley Biomedical Research Centre at South London and Maudsley NHS Foundation Trust & Institute of Psychiatry, Psychology and Neuroscience, King’s College LondonNIHR BioResource Centre Maudsley, NIHR Maudsley Biomedical Research Centre at South London and Maudsley NHS Foundation Trust & Institute of Psychiatry, Psychology and Neuroscience, King’s College LondonResearch Department of Early Life Imaging, School of Biomedical Engineering and Imaging Sciences, King’s College LondonResearch Department of Early Life Imaging, School of Biomedical Engineering and Imaging Sciences, King’s College LondonResearch Department of Early Life Imaging, School of Biomedical Engineering and Imaging Sciences, King’s College LondonResearch Department of Early Life Imaging, School of Biomedical Engineering and Imaging Sciences, King’s College LondonResearch Department of Early Life Imaging, School of Biomedical Engineering and Imaging Sciences, King’s College LondonResearch Department of Early Life Imaging, School of Biomedical Engineering and Imaging Sciences, King’s College LondonAbstract Increasing lines of evidence suggest cerebral overgrowth in autism spectrum disorder (ASD) children in early life, but few studies have examined the effect of ASD common genetic variants on brain volumes in a general paediatric population. This study examined the association between ASD polygenic risk score (PRS) and volumes of the frontal, temporal, parietal, occipital, fronto-temporal and parieto-occipital lobes in 273 term-born infants of European ancestry in the developing Human Connectome Project. ASD PRS was positively associated with frontal (β = 0.027, p FDR = 0.04) and fronto-temporal (β = 0.024, p FDR = 0.01) volumes, but negatively with parietal (β = −0.037, p FDR = 0.04) and parieto-occipital (β = −0.033, p FDR = 0.01) volumes. This preliminary result suggests the potential involvement of ASD common genetic variants in early structural variations linked to ASD.https://doi.org/10.1038/s41398-025-03253-2 |
| spellingShingle | Hai Le Daphna Fenchel Konstantina Dimitrakopoulou Hamel Patel Charles Curtis Lucilio Cordero-Grande A. David Edwards Joseph Hajnal Jacques-Donald Tournier Maria Deprez Harriet Cullen Autism spectrum disorder common variants associated with regional lobe volume variations at birth: cross-sectional study in 273 European term neonates in developing human connectome project Translational Psychiatry |
| title | Autism spectrum disorder common variants associated with regional lobe volume variations at birth: cross-sectional study in 273 European term neonates in developing human connectome project |
| title_full | Autism spectrum disorder common variants associated with regional lobe volume variations at birth: cross-sectional study in 273 European term neonates in developing human connectome project |
| title_fullStr | Autism spectrum disorder common variants associated with regional lobe volume variations at birth: cross-sectional study in 273 European term neonates in developing human connectome project |
| title_full_unstemmed | Autism spectrum disorder common variants associated with regional lobe volume variations at birth: cross-sectional study in 273 European term neonates in developing human connectome project |
| title_short | Autism spectrum disorder common variants associated with regional lobe volume variations at birth: cross-sectional study in 273 European term neonates in developing human connectome project |
| title_sort | autism spectrum disorder common variants associated with regional lobe volume variations at birth cross sectional study in 273 european term neonates in developing human connectome project |
| url | https://doi.org/10.1038/s41398-025-03253-2 |
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