Targeting ferroptosis in prostate cancer management: molecular mechanisms, multidisciplinary strategies and translational perspectives
Abstract Prostate cancer (PCa) is a kind of malignant solid tumor commonly observed among males worldwide. The dilemma of increasing incidence with therapeutic resistance has become the leading issue in PCa clinical management. Ferroptosis is a new form of regulatory cell death caused by iron-depend...
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| Format: | Article |
| Language: | English |
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BMC
2025-02-01
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| Series: | Journal of Translational Medicine |
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| Online Access: | https://doi.org/10.1186/s12967-025-06180-4 |
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| author | Hubo Yang Xuefeng Zhang Zongming Jia He Wang Jixiang Wu Xuedong Wei Yuhua Huang Wenying Yan Yuxin Lin |
| author_facet | Hubo Yang Xuefeng Zhang Zongming Jia He Wang Jixiang Wu Xuedong Wei Yuhua Huang Wenying Yan Yuxin Lin |
| author_sort | Hubo Yang |
| collection | DOAJ |
| description | Abstract Prostate cancer (PCa) is a kind of malignant solid tumor commonly observed among males worldwide. The dilemma of increasing incidence with therapeutic resistance has become the leading issue in PCa clinical management. Ferroptosis is a new form of regulatory cell death caused by iron-dependent lipid peroxidation, which has a dual role in PCa evolution and treatment due to the multi-omics cascade of interactions among pathways and environmental stimuli. Hence deciphering the role of ferroptosis in carcinogenesis would provide novel insights and strategies for precision medicine and personalized healthcare against PCa. In this study, the mechanisms of ferroptosis during cancer development were summarized both at the molecular and tumor microenvironment level. Then literature-reported ferroptosis-related signatures in PCa, e.g., genes, non-coding RNAs, metabolites, natural products and drug components, were manually collected and functionally compared as drivers/inducers, suppressors/inhibitors, and biomarkers according to their regulatory patterns in PCa ferroptosis and pathogenesis. The state-of-the-art techniques for ferroptosis-related data integration, knowledge identification, and translational application to PCa theranostics were discussed from a combinative perspective of artificial intelligence-powered modelling and advanced material-oriented therapeutic scheme design. The prospects and challenges in ferroptosis-based PCa researches were finally highlighted to light up future wisdoms for the flourishing of current findings from bench to bedside. |
| format | Article |
| id | doaj-art-04b60995785a4ff3b9378a619ea1bd27 |
| institution | Kabale University |
| issn | 1479-5876 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Translational Medicine |
| spelling | doaj-art-04b60995785a4ff3b9378a619ea1bd272025-02-09T12:52:31ZengBMCJournal of Translational Medicine1479-58762025-02-0123112010.1186/s12967-025-06180-4Targeting ferroptosis in prostate cancer management: molecular mechanisms, multidisciplinary strategies and translational perspectivesHubo Yang0Xuefeng Zhang1Zongming Jia2He Wang3Jixiang Wu4Xuedong Wei5Yuhua Huang6Wenying Yan7Yuxin Lin8Department of Urology, The First Affiliated Hospital of Soochow UniversityDepartment of Urology, The First Affiliated Hospital of Soochow UniversityDepartment of Urology, The First Affiliated Hospital of Soochow UniversityDepartment of Urology, The First Affiliated Hospital of Soochow UniversityDepartment of Urology, The First Affiliated Hospital of Soochow UniversityDepartment of Urology, The First Affiliated Hospital of Soochow UniversityDepartment of Urology, The First Affiliated Hospital of Soochow UniversitySuzhou Key Lab of Multi-modal Data Fusion and Intelligent HealthcareDepartment of Urology, The First Affiliated Hospital of Soochow UniversityAbstract Prostate cancer (PCa) is a kind of malignant solid tumor commonly observed among males worldwide. The dilemma of increasing incidence with therapeutic resistance has become the leading issue in PCa clinical management. Ferroptosis is a new form of regulatory cell death caused by iron-dependent lipid peroxidation, which has a dual role in PCa evolution and treatment due to the multi-omics cascade of interactions among pathways and environmental stimuli. Hence deciphering the role of ferroptosis in carcinogenesis would provide novel insights and strategies for precision medicine and personalized healthcare against PCa. In this study, the mechanisms of ferroptosis during cancer development were summarized both at the molecular and tumor microenvironment level. Then literature-reported ferroptosis-related signatures in PCa, e.g., genes, non-coding RNAs, metabolites, natural products and drug components, were manually collected and functionally compared as drivers/inducers, suppressors/inhibitors, and biomarkers according to their regulatory patterns in PCa ferroptosis and pathogenesis. The state-of-the-art techniques for ferroptosis-related data integration, knowledge identification, and translational application to PCa theranostics were discussed from a combinative perspective of artificial intelligence-powered modelling and advanced material-oriented therapeutic scheme design. The prospects and challenges in ferroptosis-based PCa researches were finally highlighted to light up future wisdoms for the flourishing of current findings from bench to bedside.https://doi.org/10.1186/s12967-025-06180-4Prostate cancerFerroptosisMulti-omics signaturesMultidisciplinary characterizationTranslational systems biology |
| spellingShingle | Hubo Yang Xuefeng Zhang Zongming Jia He Wang Jixiang Wu Xuedong Wei Yuhua Huang Wenying Yan Yuxin Lin Targeting ferroptosis in prostate cancer management: molecular mechanisms, multidisciplinary strategies and translational perspectives Journal of Translational Medicine Prostate cancer Ferroptosis Multi-omics signatures Multidisciplinary characterization Translational systems biology |
| title | Targeting ferroptosis in prostate cancer management: molecular mechanisms, multidisciplinary strategies and translational perspectives |
| title_full | Targeting ferroptosis in prostate cancer management: molecular mechanisms, multidisciplinary strategies and translational perspectives |
| title_fullStr | Targeting ferroptosis in prostate cancer management: molecular mechanisms, multidisciplinary strategies and translational perspectives |
| title_full_unstemmed | Targeting ferroptosis in prostate cancer management: molecular mechanisms, multidisciplinary strategies and translational perspectives |
| title_short | Targeting ferroptosis in prostate cancer management: molecular mechanisms, multidisciplinary strategies and translational perspectives |
| title_sort | targeting ferroptosis in prostate cancer management molecular mechanisms multidisciplinary strategies and translational perspectives |
| topic | Prostate cancer Ferroptosis Multi-omics signatures Multidisciplinary characterization Translational systems biology |
| url | https://doi.org/10.1186/s12967-025-06180-4 |
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