The development and evaluation of a tublysine-based antibody-drug conjugate with enhanced tumor therapeutic efficacy

The development and evaluation of a tublysine-based antibody-drug conjugate with enhanced tumor therapeutic efficacy

Antibody-drug conjugates (ADCs) offer targeted cancer therapy by delivering cytotoxic agents directly to tumor cells. However, challenges such as relapse, resistance, and diverse patient needs drive ongoing innovation in ADC development. Exploration of new small-molecule toxins with unique antitumor...

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Bibliographic Details
Main Authors:	Huihui Guo, Hongsheng Xie, Yuanyuan Huang, Junxiang Jia, Xiangfei Kong, Qingliang Yang, Shun Gai, Wenjun Li, Lu Bai, Lingli Zhang, Xiaoxiao Chen, Zhicang Ye, Hangbo Ye, Linyao Zhao, Yifang Xu, Yong Du, Xiuzhen Zhang, Miaomiao Chen, Xiaomai Zhou, Robert Y. Zhao
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-02-01
Series:	Frontiers in Pharmacology
Subjects:	Tub114 DX126-262 tubulysin B analog target-specific delivery HER2 therapeutic window
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2025.1532104/full
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