Chronic wounds and adaptive Pseudomonas aeruginosa: A phenotypic and genotypic characterization
Phenotypic and genetic diversity is found in varying prevalence in clinical populations where beneficial adaptations enable the bacteria to avoid recognition and eradication by the host immune system. This study aimed to investigate the presence of Pseudomonas aeruginosa in chronic venous leg ulcers...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-01-01
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| Series: | Current Research in Microbial Sciences |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666517425000100 |
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| author | Kasandra Buchholtz Rie Jønsson Rasmus L. Marvig Biljana Mojsoska Karen Angeliki Krogfelt |
| author_facet | Kasandra Buchholtz Rie Jønsson Rasmus L. Marvig Biljana Mojsoska Karen Angeliki Krogfelt |
| author_sort | Kasandra Buchholtz |
| collection | DOAJ |
| description | Phenotypic and genetic diversity is found in varying prevalence in clinical populations where beneficial adaptations enable the bacteria to avoid recognition and eradication by the host immune system. This study aimed to investigate the presence of Pseudomonas aeruginosa in chronic venous leg ulcers wounds over an 8-week time course. This was performed using genomic and phenotypic approaches to understand the survival and persistence of Pseudomonas strains. The findings of this study show that the two patients were colonized with a recurring P. aeruginosa genotype with only minor phenotypic differences and few SNP differences, suggesting that the Pseudomonas isolates present in the wound can survive and proliferate in the host's hostile environment. The results provided from this study will allow us to understand P. aeruginosa colonization during a 8 week time period. |
| format | Article |
| id | doaj-art-06354b0373414b1293fa8219d7074165 |
| institution | Kabale University |
| issn | 2666-5174 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Current Research in Microbial Sciences |
| spelling | doaj-art-06354b0373414b1293fa8219d70741652025-02-12T05:32:51ZengElsevierCurrent Research in Microbial Sciences2666-51742025-01-018100348Chronic wounds and adaptive Pseudomonas aeruginosa: A phenotypic and genotypic characterizationKasandra Buchholtz0Rie Jønsson1Rasmus L. Marvig2Biljana Mojsoska3Karen Angeliki Krogfelt4Department of Science and Environment, Roskilde University, DenmarkDepartment of Science and Environment, Roskilde University, DenmarkDepartment of Genomic Medicine, Rigshospitalet, Copenhagen, DenmarkDepartment of Science and Environment, Roskilde University, DenmarkDepartment of Science and Environment, Roskilde University, Denmark; Corresponding author.Phenotypic and genetic diversity is found in varying prevalence in clinical populations where beneficial adaptations enable the bacteria to avoid recognition and eradication by the host immune system. This study aimed to investigate the presence of Pseudomonas aeruginosa in chronic venous leg ulcers wounds over an 8-week time course. This was performed using genomic and phenotypic approaches to understand the survival and persistence of Pseudomonas strains. The findings of this study show that the two patients were colonized with a recurring P. aeruginosa genotype with only minor phenotypic differences and few SNP differences, suggesting that the Pseudomonas isolates present in the wound can survive and proliferate in the host's hostile environment. The results provided from this study will allow us to understand P. aeruginosa colonization during a 8 week time period.http://www.sciencedirect.com/science/article/pii/S2666517425000100Pseudomonas aeruginosaAdaptationPhylogenetic diversityMorphologyChronic wound |
| spellingShingle | Kasandra Buchholtz Rie Jønsson Rasmus L. Marvig Biljana Mojsoska Karen Angeliki Krogfelt Chronic wounds and adaptive Pseudomonas aeruginosa: A phenotypic and genotypic characterization Current Research in Microbial Sciences Pseudomonas aeruginosa Adaptation Phylogenetic diversity Morphology Chronic wound |
| title | Chronic wounds and adaptive Pseudomonas aeruginosa: A phenotypic and genotypic characterization |
| title_full | Chronic wounds and adaptive Pseudomonas aeruginosa: A phenotypic and genotypic characterization |
| title_fullStr | Chronic wounds and adaptive Pseudomonas aeruginosa: A phenotypic and genotypic characterization |
| title_full_unstemmed | Chronic wounds and adaptive Pseudomonas aeruginosa: A phenotypic and genotypic characterization |
| title_short | Chronic wounds and adaptive Pseudomonas aeruginosa: A phenotypic and genotypic characterization |
| title_sort | chronic wounds and adaptive pseudomonas aeruginosa a phenotypic and genotypic characterization |
| topic | Pseudomonas aeruginosa Adaptation Phylogenetic diversity Morphology Chronic wound |
| url | http://www.sciencedirect.com/science/article/pii/S2666517425000100 |
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