Vaccines in the fight against antimicrobial resistance – perspectives from South Africa
Antimicrobial resistance (AMR), in which microbes adapt to and resist current therapies, is a well-recognised global problem that threatens to reverse gains made by modern medicine in the last decades. AMR is a complex issue; however, at its core, it is driven by the overuse and inappropriate u...
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| Format: | Article |
| Language: | English |
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South African Medical Association
2024-09-01
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| Series: | South African Medical Journal |
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| Online Access: | https://samajournals.co.za/index.php/samj/article/view/2111 |
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| author | A Brink A Kgasi A Musyoki B Kagina C Feldman D Reddy E du Toit E Kalanxhi J Meyer I Impalli M Schönfeldt M Sibanda N Schellack P Skosana S Essack S Dlamini Y Ramsamy |
| author_facet | A Brink A Kgasi A Musyoki B Kagina C Feldman D Reddy E du Toit E Kalanxhi J Meyer I Impalli M Schönfeldt M Sibanda N Schellack P Skosana S Essack S Dlamini Y Ramsamy |
| author_sort | A Brink |
| collection | DOAJ |
| description |
Antimicrobial resistance (AMR), in which microbes adapt to and resist current therapies, is a well-recognised global problem that threatens to reverse gains made by modern medicine in the last decades. AMR is a complex issue; however, at its core, it is driven by the overuse and inappropriate use of antimicrobials. Socioeconomic factors have been identified as significant contributors to the emergence and exacerbation of AMR, especially in populations facing inadequate access to healthcare, poor sanitation services and high morbidity and mortality rates. Weak healthcare systems and water, sanitation and hygiene have been highlighted as fundamental risk factors for AMR emergence and transmission. Behavioural factors, such as purchasing antibiotics without a prescription from a registered healthcare professional, not completing the prescribed course or overly prolonged courses of antibiotics, using antibiotics to treat viral infections, lack of access to quality antibiotics, and the proliferation of substandard or falsified (SF) drugs, have also been identified as significant contributors to AMR. Low- and middle-income countries have a higher incidence of antibiotics being dispensed without a prescription than higher-income countries.
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| format | Article |
| id | doaj-art-074ed9f42b59475a854a1f287fedd799 |
| institution | Kabale University |
| issn | 0256-9574 2078-5135 |
| language | English |
| publishDate | 2024-09-01 |
| publisher | South African Medical Association |
| record_format | Article |
| series | South African Medical Journal |
| spelling | doaj-art-074ed9f42b59475a854a1f287fedd7992025-02-10T12:25:41ZengSouth African Medical AssociationSouth African Medical Journal0256-95742078-51352024-09-01114910.7196/SAMJ.2024.v114i9.2111Vaccines in the fight against antimicrobial resistance – perspectives from South AfricaA Brink0A Kgasi1A Musyoki2B Kagina3C Feldman4D Reddy5E du Toit6E Kalanxhi7J Meyer8I Impalli 9M Schönfeldt10M Sibanda11N Schellack12P Skosana 13S Essack 14S Dlamini15Y Ramsamy16Division of Medical Microbiology, Faculty of Health Sciences, University of Cape Town, South Africa; National Health Laboratory Service, Groote Schuur Hospital, Cape Town, South Africa; Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, South AfricaDepartment of Production Animal Studies, Faculty of Veterinary Science, University of Pretoria, South AfricaDepartment of Microbiological Pathology, School of Medicine, Sefako Makgatho Health Sciences University, Pretoria, South AfricaVaccines for Africa and NITAGs Support Hub, School of Public Health, Faculty of Health Sciences, University of Cape Town, South AfricaDepartment of Internal Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South AfricaVaccines and Infectious Diseases Analytics Research Unit (Wits-VIDA), Johannesburg, South Africa; Division of Infectious Diseases, Department of Internal Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South AfricaOne Health Trust, Washington DC, USAOne Health Trust, Washington DC, USADepartment of Public Health Pharmacy and Management, School of Pharmacy, Sefako Makgatho Health Sciences University, Pretoria, South Africa; South African Vaccination and Immunisation Centre, Sefako Makgatho Health Sciences University, Pretoria, South AfricaOne Health Trust, Washington DC, USAChild, Youth and School Health Directorate, National Department of Health, Pretoria, South AfricaDepartment of Clinical Pharmacy, School of Pharmacy, Faculty of Health Sciences, Sefako Makgatho Health Sciences University, Pretoria, South AfricaDepartment of Pharmacology, School of Medicine, Faculty of Health Sciences, University of Pretoria, South AfricaDepartment of Pharmacology, School of Medicine, Faculty of Health Sciences, University of Pretoria, South AfricaAntimicrobial Research Unit, School of Health Sciences, University of KwaZulu-Natal, Durban, South AfricaDivision of Infectious Diseases and HIV Medicine, Department of Medicine, Groote Schuur Hospital, University of Cape Town, South AfricaDivision of Medical Microbiology, College of Health Sciences, University of KwaZulu-Natal, Durban, South Africa Antimicrobial resistance (AMR), in which microbes adapt to and resist current therapies, is a well-recognised global problem that threatens to reverse gains made by modern medicine in the last decades. AMR is a complex issue; however, at its core, it is driven by the overuse and inappropriate use of antimicrobials. Socioeconomic factors have been identified as significant contributors to the emergence and exacerbation of AMR, especially in populations facing inadequate access to healthcare, poor sanitation services and high morbidity and mortality rates. Weak healthcare systems and water, sanitation and hygiene have been highlighted as fundamental risk factors for AMR emergence and transmission. Behavioural factors, such as purchasing antibiotics without a prescription from a registered healthcare professional, not completing the prescribed course or overly prolonged courses of antibiotics, using antibiotics to treat viral infections, lack of access to quality antibiotics, and the proliferation of substandard or falsified (SF) drugs, have also been identified as significant contributors to AMR. Low- and middle-income countries have a higher incidence of antibiotics being dispensed without a prescription than higher-income countries. https://samajournals.co.za/index.php/samj/article/view/2111health care systemsdrugsantimicrobial |
| spellingShingle | A Brink A Kgasi A Musyoki B Kagina C Feldman D Reddy E du Toit E Kalanxhi J Meyer I Impalli M Schönfeldt M Sibanda N Schellack P Skosana S Essack S Dlamini Y Ramsamy Vaccines in the fight against antimicrobial resistance – perspectives from South Africa South African Medical Journal health care systems drugs antimicrobial |
| title | Vaccines in the fight against antimicrobial resistance – perspectives from South Africa |
| title_full | Vaccines in the fight against antimicrobial resistance – perspectives from South Africa |
| title_fullStr | Vaccines in the fight against antimicrobial resistance – perspectives from South Africa |
| title_full_unstemmed | Vaccines in the fight against antimicrobial resistance – perspectives from South Africa |
| title_short | Vaccines in the fight against antimicrobial resistance – perspectives from South Africa |
| title_sort | vaccines in the fight against antimicrobial resistance perspectives from south africa |
| topic | health care systems drugs antimicrobial |
| url | https://samajournals.co.za/index.php/samj/article/view/2111 |
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