The influence of menopause age on gynecologic cancer risk: a comprehensive analysis using NHANES data
BackgroundMenopause, a natural transition, affects women’s health risks, including gynecologic cancers. Early menopause, linked to lower estrogen, may increase cancer susceptibility. This study analyzed NHANES data from 1999 to 2020 for 8,219 postmenopausal women to explore the relationship between...
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2025.1541585/full |
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| author | Yiliminuer Abulajiang Tao Liu Ming Wang Abidan Abulai Yumei Wu |
| author_facet | Yiliminuer Abulajiang Tao Liu Ming Wang Abidan Abulai Yumei Wu |
| author_sort | Yiliminuer Abulajiang |
| collection | DOAJ |
| description | BackgroundMenopause, a natural transition, affects women’s health risks, including gynecologic cancers. Early menopause, linked to lower estrogen, may increase cancer susceptibility. This study analyzed NHANES data from 1999 to 2020 for 8,219 postmenopausal women to explore the relationship between menopausal age and gynecologic cancers. We used regression models and RCS models to assess the risk.MethodsThis study utilized data from the NHANES spanning 1999 to 2020, focusing on 8,219 postmenopausal women selected through stratified sampling. Variables including socioeconomic factors, health behaviors, nutritional status, and medical history were assessed in relation to participants’ menopausal age and gynecologic cancer prevalence. We analyzed the relationship between menopausal age and gynecologic cancers (cervical, ovarian, and uterine) using multiple regression models. Additionally, we employed RCS models to evaluate nonlinear relationships between menopausal age and gynecologic cancer risk.ResultsOur findings indicate a significant inverse association between menopausal age and the risk of gynecologic cancers. After controlling for confounding factors such as age, race, BMI, and lifestyle variables, a later age at menopause was associated with a reduced risk of cervical, ovarian, and uterine cancers. The RCS model revealed a non-linear, low-L-shaped relationship, particularly highlighting increased cancer risks at younger menopausal ages. Subgroup analyses demonstrated consistent results across demographic and lifestyle factors, confirming the robustness of the observed associations.ConclusionThis study reveals the link between menopausal age and gynecologic cancer prevalence. Early menopause is a significant risk factor for cervical, ovarian, and uterine cancers. Our findings support tailored cancer screening based on menopausal age, potentially improving preventive care for postmenopausal women. |
| format | Article |
| id | doaj-art-078507cea4174def80c3eb7e9f442c74 |
| institution | Kabale University |
| issn | 2234-943X |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj-art-078507cea4174def80c3eb7e9f442c742025-02-11T12:22:40ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2025-02-011510.3389/fonc.2025.15415851541585The influence of menopause age on gynecologic cancer risk: a comprehensive analysis using NHANES dataYiliminuer Abulajiang0Tao Liu1Ming Wang2Abidan Abulai3Yumei Wu4Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital, Beijing, ChinaSchool of Rehabilitation Medicine, Baoding University of Technology, Baoding, ChinaBeijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital, Beijing, ChinaDepartment of Endocrinology, The First People’s Hospital of Kashi, (The Affiliated Kashi Hospital of Sun Yat-Sen University), Kashi, ChinaBeijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital, Beijing, ChinaBackgroundMenopause, a natural transition, affects women’s health risks, including gynecologic cancers. Early menopause, linked to lower estrogen, may increase cancer susceptibility. This study analyzed NHANES data from 1999 to 2020 for 8,219 postmenopausal women to explore the relationship between menopausal age and gynecologic cancers. We used regression models and RCS models to assess the risk.MethodsThis study utilized data from the NHANES spanning 1999 to 2020, focusing on 8,219 postmenopausal women selected through stratified sampling. Variables including socioeconomic factors, health behaviors, nutritional status, and medical history were assessed in relation to participants’ menopausal age and gynecologic cancer prevalence. We analyzed the relationship between menopausal age and gynecologic cancers (cervical, ovarian, and uterine) using multiple regression models. Additionally, we employed RCS models to evaluate nonlinear relationships between menopausal age and gynecologic cancer risk.ResultsOur findings indicate a significant inverse association between menopausal age and the risk of gynecologic cancers. After controlling for confounding factors such as age, race, BMI, and lifestyle variables, a later age at menopause was associated with a reduced risk of cervical, ovarian, and uterine cancers. The RCS model revealed a non-linear, low-L-shaped relationship, particularly highlighting increased cancer risks at younger menopausal ages. Subgroup analyses demonstrated consistent results across demographic and lifestyle factors, confirming the robustness of the observed associations.ConclusionThis study reveals the link between menopausal age and gynecologic cancer prevalence. Early menopause is a significant risk factor for cervical, ovarian, and uterine cancers. Our findings support tailored cancer screening based on menopausal age, potentially improving preventive care for postmenopausal women.https://www.frontiersin.org/articles/10.3389/fonc.2025.1541585/fullmenopause agegynecologic cancer riskpersonalized cancer screeningNHANES data analysisrisk stratification |
| spellingShingle | Yiliminuer Abulajiang Tao Liu Ming Wang Abidan Abulai Yumei Wu The influence of menopause age on gynecologic cancer risk: a comprehensive analysis using NHANES data Frontiers in Oncology menopause age gynecologic cancer risk personalized cancer screening NHANES data analysis risk stratification |
| title | The influence of menopause age on gynecologic cancer risk: a comprehensive analysis using NHANES data |
| title_full | The influence of menopause age on gynecologic cancer risk: a comprehensive analysis using NHANES data |
| title_fullStr | The influence of menopause age on gynecologic cancer risk: a comprehensive analysis using NHANES data |
| title_full_unstemmed | The influence of menopause age on gynecologic cancer risk: a comprehensive analysis using NHANES data |
| title_short | The influence of menopause age on gynecologic cancer risk: a comprehensive analysis using NHANES data |
| title_sort | influence of menopause age on gynecologic cancer risk a comprehensive analysis using nhanes data |
| topic | menopause age gynecologic cancer risk personalized cancer screening NHANES data analysis risk stratification |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2025.1541585/full |
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