Preliminary analysis of the role of small hepatitis B surface proteins mutations in the pathogenesis of occult hepatitis B infection via the endoplasmic reticulum stress-induced UPR-ERAD pathway

Preliminary analysis of the role of small hepatitis B surface proteins mutations in the pathogenesis of occult hepatitis B infection via the endoplasmic reticulum stress-induced UPR-ERAD pathway

A growing body of evidence has shown that hepatitis B surface antigen (HBsAg) mutations can influence the occurrence of occult hepatitis B infection (OBI), particularly amino acid substitutions in small hepatitis B surface proteins (SHBs). The mechanistic basis for these results, however, remains un...

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Bibliographic Details
Main Authors: Huang Chengrong, Zhang Hao, Wang Jing, Li Jianfei, Liu Qian, Zong Qiyin, Zhang Yunyun, Wang Qin, Zhou Qiang
Format: Article
Language:English
Published: De Gruyter 2025-02-01
Series:Open Life Sciences
Subjects:
occult hepatitis b virus infection
hepatitis b surface antigen
mutation
endoplasmic reticulum stress
er-associated protein degradation
Online Access:https://doi.org/10.1515/biol-2022-0951
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