Serum levels of the Parkinson's disease-linked protein Parkin are specifically elevated in COVID-19
Background: Coronavirus disease 2019 (COVID-19) is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and is known to cause various unfavorable effects, including neurodegenerative disorders. The aim of the present study was to assess comparative serum protein profiles specif...
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Elsevier
2025-02-01
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| Series: | Journal of Clinical Virology Plus |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667038025000055 |
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| author | Nadezhda G. Gumanova Natalya L. Bogdanova Alexander Yu. Gorshkov |
| author_facet | Nadezhda G. Gumanova Natalya L. Bogdanova Alexander Yu. Gorshkov |
| author_sort | Nadezhda G. Gumanova |
| collection | DOAJ |
| description | Background: Coronavirus disease 2019 (COVID-19) is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and is known to cause various unfavorable effects, including neurodegenerative disorders. The aim of the present study was to assess comparative serum protein profiles specifically associated with COVID-19. Methods: COVID-19 infection was confirmed by the detection of immunoglobulin G (IgG)-SARS antibodies against SARS-CoV-2 S1 protein receptor-binding domain in serum samples collected in 2019–2021. IgG antibodies to adenovirus (IgG-AdV) were analyzed in serum samples collected in 2016–2018 prior the onset of the COVID-19 pandemic. Comparative protein profiling was conducted in matched serum samples with positive or negative IgG-SARS-status using the Signaling Explorer Antibody Array (SET100) that included 1358 specific antibodies in two replicates. This analysis identified Parkin as a top protein discriminating between the SARS-positive and negative status. The results were validated using in-house ELISA in the serum of participants recruited in 2019- 2021. Specificity versus another viral infection was tested in the serum samples with positive or negative status of IgG-AdV antibodies. Results: High serum levels of the Parkinson's disease-linked protein Parkin were associated with SARS-positive status (P < 0.05) but were not associated with IgG-AdV-positive-status (P > 0.05). Conclusions: Specific associations of Parkin with COVID-19 contribute to identification of the signaling pathways linked to COVID-19 effects. |
| format | Article |
| id | doaj-art-08ccba197e40434482e10451411e9ddd |
| institution | Kabale University |
| issn | 2667-0380 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Clinical Virology Plus |
| spelling | doaj-art-08ccba197e40434482e10451411e9ddd2025-02-08T05:01:34ZengElsevierJournal of Clinical Virology Plus2667-03802025-02-0151100206Serum levels of the Parkinson's disease-linked protein Parkin are specifically elevated in COVID-19Nadezhda G. Gumanova0Natalya L. Bogdanova1Alexander Yu. Gorshkov2Corresponding author at: Department of Biochemistry, National Research Center for Preventive Medicine, 10 Petroverigsky per., building 3, Moscow 101990, Russia.; National Research Center for Preventive Medicine (NRCPM), Petroverigsky, 10, building 3 Moscow 101990, RussiaNational Research Center for Preventive Medicine (NRCPM), Petroverigsky, 10, building 3 Moscow 101990, RussiaNational Research Center for Preventive Medicine (NRCPM), Petroverigsky, 10, building 3 Moscow 101990, RussiaBackground: Coronavirus disease 2019 (COVID-19) is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and is known to cause various unfavorable effects, including neurodegenerative disorders. The aim of the present study was to assess comparative serum protein profiles specifically associated with COVID-19. Methods: COVID-19 infection was confirmed by the detection of immunoglobulin G (IgG)-SARS antibodies against SARS-CoV-2 S1 protein receptor-binding domain in serum samples collected in 2019–2021. IgG antibodies to adenovirus (IgG-AdV) were analyzed in serum samples collected in 2016–2018 prior the onset of the COVID-19 pandemic. Comparative protein profiling was conducted in matched serum samples with positive or negative IgG-SARS-status using the Signaling Explorer Antibody Array (SET100) that included 1358 specific antibodies in two replicates. This analysis identified Parkin as a top protein discriminating between the SARS-positive and negative status. The results were validated using in-house ELISA in the serum of participants recruited in 2019- 2021. Specificity versus another viral infection was tested in the serum samples with positive or negative status of IgG-AdV antibodies. Results: High serum levels of the Parkinson's disease-linked protein Parkin were associated with SARS-positive status (P < 0.05) but were not associated with IgG-AdV-positive-status (P > 0.05). Conclusions: Specific associations of Parkin with COVID-19 contribute to identification of the signaling pathways linked to COVID-19 effects.http://www.sciencedirect.com/science/article/pii/S2667038025000055Parkin proteinSerum proteome profilingSerum biomarkersCOVID-19Adenovirus |
| spellingShingle | Nadezhda G. Gumanova Natalya L. Bogdanova Alexander Yu. Gorshkov Serum levels of the Parkinson's disease-linked protein Parkin are specifically elevated in COVID-19 Journal of Clinical Virology Plus Parkin protein Serum proteome profiling Serum biomarkers COVID-19 Adenovirus |
| title | Serum levels of the Parkinson's disease-linked protein Parkin are specifically elevated in COVID-19 |
| title_full | Serum levels of the Parkinson's disease-linked protein Parkin are specifically elevated in COVID-19 |
| title_fullStr | Serum levels of the Parkinson's disease-linked protein Parkin are specifically elevated in COVID-19 |
| title_full_unstemmed | Serum levels of the Parkinson's disease-linked protein Parkin are specifically elevated in COVID-19 |
| title_short | Serum levels of the Parkinson's disease-linked protein Parkin are specifically elevated in COVID-19 |
| title_sort | serum levels of the parkinson s disease linked protein parkin are specifically elevated in covid 19 |
| topic | Parkin protein Serum proteome profiling Serum biomarkers COVID-19 Adenovirus |
| url | http://www.sciencedirect.com/science/article/pii/S2667038025000055 |
| work_keys_str_mv | AT nadezhdaggumanova serumlevelsoftheparkinsonsdiseaselinkedproteinparkinarespecificallyelevatedincovid19 AT natalyalbogdanova serumlevelsoftheparkinsonsdiseaselinkedproteinparkinarespecificallyelevatedincovid19 AT alexanderyugorshkov serumlevelsoftheparkinsonsdiseaselinkedproteinparkinarespecificallyelevatedincovid19 |