Cerebellum abnormalities in vascular mild cognitive impairment with depression symptom patients: A multimodal magnetic resonance imaging study
Background: Subcortical vascular mild cognitive impairment (svMCI) frequently occurs alongside depression symptoms, significantly affecting patients' quality of life. While cognitive decline and depression symptoms are linked to cerebellar changes, the specific relationship between these change...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-02-01
|
| Series: | Brain Research Bulletin |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0361923025000255 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1825206922163257344 |
|---|---|
| author | Yirong Chen Liling Chen Liyu Hu Jianjun Wang Jinhuan Zhang Hanqing Lyu Jinping Xu Jianxiang Chen Haibo Yu |
| author_facet | Yirong Chen Liling Chen Liyu Hu Jianjun Wang Jinhuan Zhang Hanqing Lyu Jinping Xu Jianxiang Chen Haibo Yu |
| author_sort | Yirong Chen |
| collection | DOAJ |
| description | Background: Subcortical vascular mild cognitive impairment (svMCI) frequently occurs alongside depression symptoms, significantly affecting patients' quality of life. While cognitive decline and depression symptoms are linked to cerebellar changes, the specific relationship between these changes and cognitive status in svMCI patients with depression symptoms remains unclear. Objective: This study aimed to investigates the gray matter volume and functional alterations in the cerebellum of svMCI patients, with and without depression symptoms, and their correlation with cognitive and depressive symptoms. Methods: We enrolled 16 svMCI patients with depression symptoms (svMCI+D), 15 without (svMCI-D), and 12 normal controls (NC). Multimodal MRI scans were conducted, assessing gray matter volume and resting-state functional connectivity (RSFC) in the cerebellum. Correlations between RSFC and clinical scores from the Montreal Cognitive Assessment (MoCA) and Hamilton Depression Scale (HAMD) were analyzed. Results: Structural analysis indicated gray matter atrophy in left cerebellar lobules I_IV and VI (Cere6.L) in svMCI patients. svMCI+D patients showed reduced RSFC between Cere6.L and left cerebellar region IX and the left superior frontal gyrus (SFGdor.L). Both svMCI+D and svMCI-D groups showed increased RSFC between Cere6.L and the right caudate nucleus. RSFC between Cere6.L and SFGdor.L correlated negatively with HAMD scores in svMCI+D and positively with MoCA scores in svMCI-D. RSFC between Cere6.L and the right caudate nucleus also correlated positively with MoCA in the svMCI-D. Conclusion: Cerebellar abnormalities, including the gray matter atrophy and RSFC changes, are associated with svMCI, particularly when depression symptoms are present. These results suggest potential diagnostic and therapeutic implications for svMCI and emphasize the need for further research on the cerebellum's role in cognitive and emotional disorders. |
| format | Article |
| id | doaj-art-0a5c543fcf6e481a8203f3a7ad8f150d |
| institution | Kabale University |
| issn | 1873-2747 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Brain Research Bulletin |
| spelling | doaj-art-0a5c543fcf6e481a8203f3a7ad8f150d2025-02-07T04:46:45ZengElsevierBrain Research Bulletin1873-27472025-02-01221111213Cerebellum abnormalities in vascular mild cognitive impairment with depression symptom patients: A multimodal magnetic resonance imaging studyYirong Chen0Liling Chen1Liyu Hu2Jianjun Wang3Jinhuan Zhang4Hanqing Lyu5Jinping Xu6Jianxiang Chen7Haibo Yu8Department of Acupuncture and Moxibustion, The Fourth Clinical Medical College of Guangzhou University of Chinese Medicine, Shenzhen 518033, ChinaThe Fourth Clinical Medical College of Guangzhou University of Chinese Medicine, Shenzhen 518033, ChinaThe Fourth Clinical Medical College of Guangzhou University of Chinese Medicine, Shenzhen 518033, ChinaDepartment of Neurology and Psychology, The Fourth Clinical Medical College of Guangzhou University of Chinese Medicine, Shenzhen 518033, ChinaDepartment of Acupuncture and Moxibustion, The Fourth Clinical Medical College of Guangzhou University of Chinese Medicine, Shenzhen 518033, ChinaDepartment of Radiology, The Fourth Clinical Medical College of Guangzhou University of Chinese Medicine, Shenzhen 518033, ChinaInstitute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China; Corresponding authors.Department of Radiology, The Fourth Clinical Medical College of Guangzhou University of Chinese Medicine, Shenzhen 518033, China; Corresponding authors.Department of Acupuncture and Moxibustion, The Fourth Clinical Medical College of Guangzhou University of Chinese Medicine, Shenzhen 518033, China; Corresponding authors.Background: Subcortical vascular mild cognitive impairment (svMCI) frequently occurs alongside depression symptoms, significantly affecting patients' quality of life. While cognitive decline and depression symptoms are linked to cerebellar changes, the specific relationship between these changes and cognitive status in svMCI patients with depression symptoms remains unclear. Objective: This study aimed to investigates the gray matter volume and functional alterations in the cerebellum of svMCI patients, with and without depression symptoms, and their correlation with cognitive and depressive symptoms. Methods: We enrolled 16 svMCI patients with depression symptoms (svMCI+D), 15 without (svMCI-D), and 12 normal controls (NC). Multimodal MRI scans were conducted, assessing gray matter volume and resting-state functional connectivity (RSFC) in the cerebellum. Correlations between RSFC and clinical scores from the Montreal Cognitive Assessment (MoCA) and Hamilton Depression Scale (HAMD) were analyzed. Results: Structural analysis indicated gray matter atrophy in left cerebellar lobules I_IV and VI (Cere6.L) in svMCI patients. svMCI+D patients showed reduced RSFC between Cere6.L and left cerebellar region IX and the left superior frontal gyrus (SFGdor.L). Both svMCI+D and svMCI-D groups showed increased RSFC between Cere6.L and the right caudate nucleus. RSFC between Cere6.L and SFGdor.L correlated negatively with HAMD scores in svMCI+D and positively with MoCA scores in svMCI-D. RSFC between Cere6.L and the right caudate nucleus also correlated positively with MoCA in the svMCI-D. Conclusion: Cerebellar abnormalities, including the gray matter atrophy and RSFC changes, are associated with svMCI, particularly when depression symptoms are present. These results suggest potential diagnostic and therapeutic implications for svMCI and emphasize the need for further research on the cerebellum's role in cognitive and emotional disorders.http://www.sciencedirect.com/science/article/pii/S0361923025000255Subcortical vascular mild cognitive impairmentDepression symptomsCerebellumGray matter volumeFunctional connectivity |
| spellingShingle | Yirong Chen Liling Chen Liyu Hu Jianjun Wang Jinhuan Zhang Hanqing Lyu Jinping Xu Jianxiang Chen Haibo Yu Cerebellum abnormalities in vascular mild cognitive impairment with depression symptom patients: A multimodal magnetic resonance imaging study Brain Research Bulletin Subcortical vascular mild cognitive impairment Depression symptoms Cerebellum Gray matter volume Functional connectivity |
| title | Cerebellum abnormalities in vascular mild cognitive impairment with depression symptom patients: A multimodal magnetic resonance imaging study |
| title_full | Cerebellum abnormalities in vascular mild cognitive impairment with depression symptom patients: A multimodal magnetic resonance imaging study |
| title_fullStr | Cerebellum abnormalities in vascular mild cognitive impairment with depression symptom patients: A multimodal magnetic resonance imaging study |
| title_full_unstemmed | Cerebellum abnormalities in vascular mild cognitive impairment with depression symptom patients: A multimodal magnetic resonance imaging study |
| title_short | Cerebellum abnormalities in vascular mild cognitive impairment with depression symptom patients: A multimodal magnetic resonance imaging study |
| title_sort | cerebellum abnormalities in vascular mild cognitive impairment with depression symptom patients a multimodal magnetic resonance imaging study |
| topic | Subcortical vascular mild cognitive impairment Depression symptoms Cerebellum Gray matter volume Functional connectivity |
| url | http://www.sciencedirect.com/science/article/pii/S0361923025000255 |
| work_keys_str_mv | AT yirongchen cerebellumabnormalitiesinvascularmildcognitiveimpairmentwithdepressionsymptompatientsamultimodalmagneticresonanceimagingstudy AT lilingchen cerebellumabnormalitiesinvascularmildcognitiveimpairmentwithdepressionsymptompatientsamultimodalmagneticresonanceimagingstudy AT liyuhu cerebellumabnormalitiesinvascularmildcognitiveimpairmentwithdepressionsymptompatientsamultimodalmagneticresonanceimagingstudy AT jianjunwang cerebellumabnormalitiesinvascularmildcognitiveimpairmentwithdepressionsymptompatientsamultimodalmagneticresonanceimagingstudy AT jinhuanzhang cerebellumabnormalitiesinvascularmildcognitiveimpairmentwithdepressionsymptompatientsamultimodalmagneticresonanceimagingstudy AT hanqinglyu cerebellumabnormalitiesinvascularmildcognitiveimpairmentwithdepressionsymptompatientsamultimodalmagneticresonanceimagingstudy AT jinpingxu cerebellumabnormalitiesinvascularmildcognitiveimpairmentwithdepressionsymptompatientsamultimodalmagneticresonanceimagingstudy AT jianxiangchen cerebellumabnormalitiesinvascularmildcognitiveimpairmentwithdepressionsymptompatientsamultimodalmagneticresonanceimagingstudy AT haiboyu cerebellumabnormalitiesinvascularmildcognitiveimpairmentwithdepressionsymptompatientsamultimodalmagneticresonanceimagingstudy |