The drugs, interacting with opiate receptors, and their application in gastroenterological practice
The aim of review. To present information on the drugs nowadays used in gastroenterology, that interact with opiate receptors. Original positions. Opiate receptors in the body have been discovered about 35 years ago. For this time their various types have been found, many peptides are discovered, th...
Saved in:
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
Gastro LLC
2011-02-01
|
| Series: | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
| Subjects: | |
| Online Access: | https://www.gastro-j.ru/jour/article/view/1364 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1823860252640018432 |
|---|---|
| author | S. A. Bulgakov |
| author_facet | S. A. Bulgakov |
| author_sort | S. A. Bulgakov |
| collection | DOAJ |
| description | The aim of review. To present information on the drugs nowadays used in gastroenterology, that interact with opiate receptors. Original positions. Opiate receptors in the body have been discovered about 35 years ago. For this time their various types have been found, many peptides are discovered, their classes are characterized. Methods of peptide chemistry provide synthesizing hundreds of endogenous peptide compound analogues. On their basis new medicamental agents were developed. The first-ever synthetic drug manufactured on the basis of leucine-enkephaline, was the Russian drug dalargin. Article presents features of its synthesis, pharmacological effects, main directions of application: peptic ulcer of the stomach and duodenum, pancreatitis. Compounds of non-peptide nature, capable to interreact with opiate receptors are used now as well. There is information on loperamide, diphenoxylate, trimebutine and fedotozine – all these drugs find their application in treatment of intestinal diseases. Conclusion. The drugs interacting with opiate receptors, are widely used in gastroenterological practice and there are preconditions to broaden spectrum of these agents. |
| format | Article |
| id | doaj-art-0a7bbac17ee4455387a9aaa3582542f2 |
| institution | Kabale University |
| issn | 1382-4376 2658-6673 |
| language | Russian |
| publishDate | 2011-02-01 |
| publisher | Gastro LLC |
| record_format | Article |
| series | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
| spelling | doaj-art-0a7bbac17ee4455387a9aaa3582542f22025-02-10T16:14:30ZrusGastro LLCРоссийский журнал гастроэнтерологии, гепатологии, колопроктологии1382-43762658-66732011-02-012111925916The drugs, interacting with opiate receptors, and their application in gastroenterological practiceS. A. Bulgakov0Российский государственный медицинский университетThe aim of review. To present information on the drugs nowadays used in gastroenterology, that interact with opiate receptors. Original positions. Opiate receptors in the body have been discovered about 35 years ago. For this time their various types have been found, many peptides are discovered, their classes are characterized. Methods of peptide chemistry provide synthesizing hundreds of endogenous peptide compound analogues. On their basis new medicamental agents were developed. The first-ever synthetic drug manufactured on the basis of leucine-enkephaline, was the Russian drug dalargin. Article presents features of its synthesis, pharmacological effects, main directions of application: peptic ulcer of the stomach and duodenum, pancreatitis. Compounds of non-peptide nature, capable to interreact with opiate receptors are used now as well. There is information on loperamide, diphenoxylate, trimebutine and fedotozine – all these drugs find their application in treatment of intestinal diseases. Conclusion. The drugs interacting with opiate receptors, are widely used in gastroenterological practice and there are preconditions to broaden spectrum of these agents.https://www.gastro-j.ru/jour/article/view/1364opiate receptorsopioid peptidesdalarginloperamidetrimebutinepeptic ulcerpancreatitisdiarrhea |
| spellingShingle | S. A. Bulgakov The drugs, interacting with opiate receptors, and their application in gastroenterological practice Российский журнал гастроэнтерологии, гепатологии, колопроктологии opiate receptors opioid peptides dalargin loperamide trimebutine peptic ulcer pancreatitis diarrhea |
| title | The drugs, interacting with opiate receptors, and their application in gastroenterological practice |
| title_full | The drugs, interacting with opiate receptors, and their application in gastroenterological practice |
| title_fullStr | The drugs, interacting with opiate receptors, and their application in gastroenterological practice |
| title_full_unstemmed | The drugs, interacting with opiate receptors, and their application in gastroenterological practice |
| title_short | The drugs, interacting with opiate receptors, and their application in gastroenterological practice |
| title_sort | drugs interacting with opiate receptors and their application in gastroenterological practice |
| topic | opiate receptors opioid peptides dalargin loperamide trimebutine peptic ulcer pancreatitis diarrhea |
| url | https://www.gastro-j.ru/jour/article/view/1364 |
| work_keys_str_mv | AT sabulgakov thedrugsinteractingwithopiatereceptorsandtheirapplicationingastroenterologicalpractice AT sabulgakov drugsinteractingwithopiatereceptorsandtheirapplicationingastroenterologicalpractice |