Acute respiratory tract infections during the first 6 years of life – results from the German birth cohort study LoewenKIDS
Objectives: Acute respiratory tract infections (ARIs) often occur in early childhood and are mostly self-limited. However, they impose a high socioeconomic burden and can be associated with chronic diseases later in life. To date, data on self-reported ARIs beyond infancy are limited. This study aim...
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Elsevier
2025-04-01
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| Series: | International Journal of Infectious Diseases |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1201971225000268 |
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| author | Bianca Klee Sophie Diexer Susan Langer Cornelia Gottschick Carla Hartmann Nadine Glaser Johannes Horn Evelyn Dorendorf Heike Raupach-Rosin Lamiaa Hassan Nicole Rübsamen Kristin Maria Meyer-Schlinkmann Carlos A. Guzman Valerie Heselich Eva Battin Thomas Pietschmann Dietmar H. Pieper Mathias Pletz Peggy Riese Stephanie Trittel Saskia Thies Constantin von Kaisenberg Frank Dressler Florian Guthmann Carsten Oberhoff Ralf L. Schild Andre Karch Rafael Mikolajczyk |
| author_facet | Bianca Klee Sophie Diexer Susan Langer Cornelia Gottschick Carla Hartmann Nadine Glaser Johannes Horn Evelyn Dorendorf Heike Raupach-Rosin Lamiaa Hassan Nicole Rübsamen Kristin Maria Meyer-Schlinkmann Carlos A. Guzman Valerie Heselich Eva Battin Thomas Pietschmann Dietmar H. Pieper Mathias Pletz Peggy Riese Stephanie Trittel Saskia Thies Constantin von Kaisenberg Frank Dressler Florian Guthmann Carsten Oberhoff Ralf L. Schild Andre Karch Rafael Mikolajczyk |
| author_sort | Bianca Klee |
| collection | DOAJ |
| description | Objectives: Acute respiratory tract infections (ARIs) often occur in early childhood and are mostly self-limited. However, they impose a high socioeconomic burden and can be associated with chronic diseases later in life. To date, data on self-reported ARIs beyond infancy are limited. This study aimed to describe the incidence and characteristics of self-reported ARIs in the first 6 years of life. Methods: Data were obtained from the LoewenKIDS birth cohort study, including 782 children born between 2014 and 2018. Parents recorded daily ARI symptoms, which were classified into episodes for incidence and characteristics analysis. Regression analyses explored the influence of exposure factors on ARI incidence. Results: This longitudinal birth cohort study of a subsample of 258 children found a mean cumulative duration of 51.5 weeks (95% confidence interval: 47.5-55.6 weeks) of respiratory symptoms in the first 6 years of life, with large individual differences. Children with frequent infections in infancy had more infections in preschool age. Exposure factors explained only a small fraction of variation in incidence (5%). Conclusions: There is a substantial variation in susceptibility to ARIs in childhood, which is not explained by exposure factors. |
| format | Article |
| id | doaj-art-0bb5ee62b1414c209857d3e1f3994c9c |
| institution | Kabale University |
| issn | 1201-9712 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | International Journal of Infectious Diseases |
| spelling | doaj-art-0bb5ee62b1414c209857d3e1f3994c9c2025-02-10T04:34:15ZengElsevierInternational Journal of Infectious Diseases1201-97122025-04-01153107802Acute respiratory tract infections during the first 6 years of life – results from the German birth cohort study LoewenKIDSBianca Klee0Sophie Diexer1Susan Langer2Cornelia Gottschick3Carla Hartmann4Nadine Glaser5Johannes Horn6Evelyn Dorendorf7Heike Raupach-Rosin8Lamiaa Hassan9Nicole Rübsamen10Kristin Maria Meyer-Schlinkmann11Carlos A. Guzman12Valerie Heselich13Eva Battin14Thomas Pietschmann15Dietmar H. Pieper16Mathias Pletz17Peggy Riese18Stephanie Trittel19Saskia Thies20Constantin von Kaisenberg21Frank Dressler22Florian Guthmann23Carsten Oberhoff24Ralf L. Schild25Andre Karch26Rafael Mikolajczyk27Institute of Medical Epidemiology, Biometrics, and Informatics, Interdisciplinary Centre for Health Sciences, Medical Faculty of the Martin Luther University Halle-Wittenberg, Halle (Saale), GermanyInstitute of Medical Epidemiology, Biometrics, and Informatics, Interdisciplinary Centre for Health Sciences, Medical Faculty of the Martin Luther University Halle-Wittenberg, Halle (Saale), GermanyInstitute of Medical Epidemiology, Biometrics, and Informatics, Interdisciplinary Centre for Health Sciences, Medical Faculty of the Martin Luther University Halle-Wittenberg, Halle (Saale), GermanyInstitute of Medical Epidemiology, Biometrics, and Informatics, Interdisciplinary Centre for Health Sciences, Medical Faculty of the Martin Luther University Halle-Wittenberg, Halle (Saale), GermanyInstitute of Medical Epidemiology, Biometrics, and Informatics, Interdisciplinary Centre for Health Sciences, Medical Faculty of the Martin Luther University Halle-Wittenberg, Halle (Saale), GermanyInstitute of Medical Epidemiology, Biometrics, and Informatics, Interdisciplinary Centre for Health Sciences, Medical Faculty of the Martin Luther University Halle-Wittenberg, Halle (Saale), GermanyInstitute of Medical Epidemiology, Biometrics, and Informatics, Interdisciplinary Centre for Health Sciences, Medical Faculty of the Martin Luther University Halle-Wittenberg, Halle (Saale), GermanyHelmholtz Centre for Infection Research, Epidemiology Research Group Epidemiological and Statistical Methods, Braunschweig, GermanyHelmholtz Centre for Infection Research, Epidemiology Research Group Epidemiological and Statistical Methods, Braunschweig, GermanyInstitute of Medical Epidemiology, Biometrics, and Informatics, Interdisciplinary Centre for Health Sciences, Medical Faculty of the Martin Luther University Halle-Wittenberg, Halle (Saale), GermanyInstitute of Epidemiology and Social Medicine, University of Münster, Münster, GermanyMVZ Labor Krone eGbR, Siemensstraße 40, Bad Salzuflen, GermanyDepartment Vaccinology and Applied Microbiology, Helmholtz Centre for Infection Research, Braunschweig, GermanyDepartment of Paediatrics, Dr. von Hauner Children's Hospital, Ludwig- Maximilians-University Munich, Munich, GermanyDepartment of Paediatrics, Dr. von Hauner Children's Hospital, Ludwig- Maximilians-University Munich, Munich, GermanyInstitute of Experimental Virology, TWINCORE, Centre for Experimental and Clinical Infection Research; a Joint Venture Between the Medical School Hannover (MHH) and the Helmholtz Centre for Infection Research (HZI), Hannover, GermanyResearch Group Microbial Interactions and Processes, Helmholtz Centre for Infection Research, Braunschweig, GermanyInstitute for Infectious Diseases and Infection Control, University Hospital Jena, Jena, GermanyDepartment Vaccinology and Applied Microbiology, Helmholtz Centre for Infection Research, Braunschweig, GermanyDepartment Vaccinology and Applied Microbiology, Helmholtz Centre for Infection Research, Braunschweig, GermanyInstitute of Medical Epidemiology, Biometrics, and Informatics, Interdisciplinary Centre for Health Sciences, Medical Faculty of the Martin Luther University Halle-Wittenberg, Halle (Saale), GermanyDepartment of Obstetrics, Gynecology and Reproductive Medicine, Hanover Medical School, Hanover, GermanyDepartment of Pediatric Pulmonology, Allergology and Neonatology, Hanover Medical School, Hanover, GermanyDepartment of Neonatology, Children and Youth Hospital AUF DER BULT, Hanover, GermanyDepartment of Gynecology and Obstetrics, Klinikum Links der Weser, Bremen, GermanyDepartment of Obstetrics and Perinatal Medicine, DIAKOVERE Henriettenstift Hanover, GermanyInstitute of Epidemiology and Social Medicine, University of Münster, Münster, GermanyInstitute of Medical Epidemiology, Biometrics, and Informatics, Interdisciplinary Centre for Health Sciences, Medical Faculty of the Martin Luther University Halle-Wittenberg, Halle (Saale), Germany; Helmholtz Centre for Infection Research, Epidemiology Research Group Epidemiological and Statistical Methods, Braunschweig, Germany; Corresponding author: Tel.: +49345557-3571.Objectives: Acute respiratory tract infections (ARIs) often occur in early childhood and are mostly self-limited. However, they impose a high socioeconomic burden and can be associated with chronic diseases later in life. To date, data on self-reported ARIs beyond infancy are limited. This study aimed to describe the incidence and characteristics of self-reported ARIs in the first 6 years of life. Methods: Data were obtained from the LoewenKIDS birth cohort study, including 782 children born between 2014 and 2018. Parents recorded daily ARI symptoms, which were classified into episodes for incidence and characteristics analysis. Regression analyses explored the influence of exposure factors on ARI incidence. Results: This longitudinal birth cohort study of a subsample of 258 children found a mean cumulative duration of 51.5 weeks (95% confidence interval: 47.5-55.6 weeks) of respiratory symptoms in the first 6 years of life, with large individual differences. Children with frequent infections in infancy had more infections in preschool age. Exposure factors explained only a small fraction of variation in incidence (5%). Conclusions: There is a substantial variation in susceptibility to ARIs in childhood, which is not explained by exposure factors.http://www.sciencedirect.com/science/article/pii/S1201971225000268Acute respiratory infectionsBirth cohort studyPediatric infectionsInfection susceptibility |
| spellingShingle | Bianca Klee Sophie Diexer Susan Langer Cornelia Gottschick Carla Hartmann Nadine Glaser Johannes Horn Evelyn Dorendorf Heike Raupach-Rosin Lamiaa Hassan Nicole Rübsamen Kristin Maria Meyer-Schlinkmann Carlos A. Guzman Valerie Heselich Eva Battin Thomas Pietschmann Dietmar H. Pieper Mathias Pletz Peggy Riese Stephanie Trittel Saskia Thies Constantin von Kaisenberg Frank Dressler Florian Guthmann Carsten Oberhoff Ralf L. Schild Andre Karch Rafael Mikolajczyk Acute respiratory tract infections during the first 6 years of life – results from the German birth cohort study LoewenKIDS International Journal of Infectious Diseases Acute respiratory infections Birth cohort study Pediatric infections Infection susceptibility |
| title | Acute respiratory tract infections during the first 6 years of life – results from the German birth cohort study LoewenKIDS |
| title_full | Acute respiratory tract infections during the first 6 years of life – results from the German birth cohort study LoewenKIDS |
| title_fullStr | Acute respiratory tract infections during the first 6 years of life – results from the German birth cohort study LoewenKIDS |
| title_full_unstemmed | Acute respiratory tract infections during the first 6 years of life – results from the German birth cohort study LoewenKIDS |
| title_short | Acute respiratory tract infections during the first 6 years of life – results from the German birth cohort study LoewenKIDS |
| title_sort | acute respiratory tract infections during the first 6 years of life results from the german birth cohort study loewenkids |
| topic | Acute respiratory infections Birth cohort study Pediatric infections Infection susceptibility |
| url | http://www.sciencedirect.com/science/article/pii/S1201971225000268 |
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