Microbiome role in pancreatic diseases development
Aim of review. To present the modern concept on the mechanisms of pancreatic disease development and role of intestinal and oral microbiome in pancreatitis pathogenesis. Summary. Intestinal barrier dysfunction, bacterial overgrowth syndrome and endotoxinemia are features of acute pancreatitis. Image...
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| Format: | Article |
| Language: | Russian |
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Gastro LLC
2018-08-01
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| Series: | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
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| Online Access: | https://www.gastro-j.ru/jour/article/view/153 |
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| _version_ | 1823860253377167360 |
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| author | Yu. V. Evsyutina V. T. Ivashkin |
| author_facet | Yu. V. Evsyutina V. T. Ivashkin |
| author_sort | Yu. V. Evsyutina |
| collection | DOAJ |
| description | Aim of review. To present the modern concept on the mechanisms of pancreatic disease development and role of intestinal and oral microbiome in pancreatitis pathogenesis. Summary. Intestinal barrier dysfunction, bacterial overgrowth syndrome and endotoxinemia are features of acute pancreatitis. Image-recognition systems (toll-like and NOD-like receptors) and microorganism-associated molecular patterns play important role in these processes. Obtained data indicate the presence of oral and gastrointestinal microbial changes at pancreatic diseases. Subsequently,Helicobacterpyloriinfection may play a role in development of autoimmune pancreatitis and pancreatic cancer,PorphyromonasgingivalisandAggregatibacteractinomycetemcomitans- in pancreatic cancer development. Conclusion. Original study results indicate the presence of oral and bowel microbial changes in pancreatic diseases. Taking into account the ability of probiotics to stimulate production of antimicrobial peptides, normalize epithelial barrier function, limit bacterial translocation, their the application may be promising for pancreatic diseases treatment. |
| format | Article |
| id | doaj-art-0cc135d641bf4897b02f7044eecfeea3 |
| institution | Kabale University |
| issn | 1382-4376 2658-6673 |
| language | Russian |
| publishDate | 2018-08-01 |
| publisher | Gastro LLC |
| record_format | Article |
| series | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
| spelling | doaj-art-0cc135d641bf4897b02f7044eecfeea32025-02-10T16:14:29ZrusGastro LLCРоссийский журнал гастроэнтерологии, гепатологии, колопроктологии1382-43762658-66732018-08-01273111710.22416/1382-4376-2017-27-3-11-17153Microbiome role in pancreatic diseases developmentYu. V. Evsyutina0V. T. Ivashkin1Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical UniversityFederal State Autonomous Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical UniversityAim of review. To present the modern concept on the mechanisms of pancreatic disease development and role of intestinal and oral microbiome in pancreatitis pathogenesis. Summary. Intestinal barrier dysfunction, bacterial overgrowth syndrome and endotoxinemia are features of acute pancreatitis. Image-recognition systems (toll-like and NOD-like receptors) and microorganism-associated molecular patterns play important role in these processes. Obtained data indicate the presence of oral and gastrointestinal microbial changes at pancreatic diseases. Subsequently,Helicobacterpyloriinfection may play a role in development of autoimmune pancreatitis and pancreatic cancer,PorphyromonasgingivalisandAggregatibacteractinomycetemcomitans- in pancreatic cancer development. Conclusion. Original study results indicate the presence of oral and bowel microbial changes in pancreatic diseases. Taking into account the ability of probiotics to stimulate production of antimicrobial peptides, normalize epithelial barrier function, limit bacterial translocation, their the application may be promising for pancreatic diseases treatment.https://www.gastro-j.ru/jour/article/view/153микробиомпанкреатитрак поджелудочной железыобразраспознающие рецепторыпробиотикимикробиомпанкреатитрак под-желудочной железыобразраспознающие рецепто-рыпробиотики |
| spellingShingle | Yu. V. Evsyutina V. T. Ivashkin Microbiome role in pancreatic diseases development Российский журнал гастроэнтерологии, гепатологии, колопроктологии микробиом панкреатит рак поджелудочной железы образраспознающие рецепторы пробиотики микробиом панкреатит рак под-желудочной железы образраспознающие рецепто-ры пробиотики |
| title | Microbiome role in pancreatic diseases development |
| title_full | Microbiome role in pancreatic diseases development |
| title_fullStr | Microbiome role in pancreatic diseases development |
| title_full_unstemmed | Microbiome role in pancreatic diseases development |
| title_short | Microbiome role in pancreatic diseases development |
| title_sort | microbiome role in pancreatic diseases development |
| topic | микробиом панкреатит рак поджелудочной железы образраспознающие рецепторы пробиотики микробиом панкреатит рак под-желудочной железы образраспознающие рецепто-ры пробиотики |
| url | https://www.gastro-j.ru/jour/article/view/153 |
| work_keys_str_mv | AT yuvevsyutina microbiomeroleinpancreaticdiseasesdevelopment AT vtivashkin microbiomeroleinpancreaticdiseasesdevelopment |