Dietary and lifestyle indices for hyperinsulinemia and odds of MAFLD in overweight and obese children and adolescents
Abstract Lifestyle and dietary intake play a pivotal role in development of metabolic dysfunction-associated fatty liver disease(MAFLD). We performed this cross-sectional study to evaluate the association between lifestyle and dietary insulinemic potential and odds of MAFLD in overweight and obese c...
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Nature Portfolio
2025-02-01
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| author | Ali Nikparast Maryam Razavi Parmis Mirzaei Pooneh Dehghan Mahdi Amani Farani Golaleh Asghari |
| author_facet | Ali Nikparast Maryam Razavi Parmis Mirzaei Pooneh Dehghan Mahdi Amani Farani Golaleh Asghari |
| author_sort | Ali Nikparast |
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| description | Abstract Lifestyle and dietary intake play a pivotal role in development of metabolic dysfunction-associated fatty liver disease(MAFLD). We performed this cross-sectional study to evaluate the association between lifestyle and dietary insulinemic potential and odds of MAFLD in overweight and obese children and adolescents. The insulinemic potential of the diet and lifestyle was assessed by computing the scores of the empirical dietary index for hyperinsulinemia(EDIH), the empirical lifestyle index for hyperinsulinemia(ELIH), the empirical dietary index for insulin resistance(EDIR), and the empirical lifestyle index for insulin resistance(ELIR). MAFLD was diagnosed according to the consensus definitions. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated by logistic regression. A total of 334 (49.1% boys) with mean ± SD age and BMI-for-age-Z-score of 9.3 ± 1.8 and 2.55 ± 0.69, respectively, were enrolled. After adjusting for all potential confounders, participants in the highest quartile of ELIH score had greater odds of developing MAFLD (OR:3.50;95%CI:1.49–8.22) compared with those in the lowest quartile. This association remained significant among boys and pubertal ones. However, no significant association between EDIH, EDIR, or ELIR and odds of MAFLD was found. Our study suggests that the collective insulinemic potential of dietary intake, BMI, and physical activity is associated with increased odds of MAFLD. |
| format | Article |
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| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-02-01 |
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| spelling | doaj-art-0d6c458753bd40aca7d7f496af57b6892025-02-09T12:34:05ZengNature PortfolioScientific Reports2045-23222025-02-0115111210.1038/s41598-025-88969-3Dietary and lifestyle indices for hyperinsulinemia and odds of MAFLD in overweight and obese children and adolescentsAli Nikparast0Maryam Razavi1Parmis Mirzaei2Pooneh Dehghan3Mahdi Amani Farani4Golaleh Asghari5Department of Clinical Nutrition and Dietetics, Faculty of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical SciencesGrowth and development research center, Children’s Medical Center, Tehran University of Medical SciencesDepartment of Clinical Nutrition and Dietetics, Faculty of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical SciencesDepartment of Imaging, Taleghani Hospital, Shahid Beheshti University of Medical SciencesDepartment of Clinical Nutrition and Dietetics, Faculty of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical SciencesDepartment of Clinical Nutrition and Dietetics, Faculty of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical SciencesAbstract Lifestyle and dietary intake play a pivotal role in development of metabolic dysfunction-associated fatty liver disease(MAFLD). We performed this cross-sectional study to evaluate the association between lifestyle and dietary insulinemic potential and odds of MAFLD in overweight and obese children and adolescents. The insulinemic potential of the diet and lifestyle was assessed by computing the scores of the empirical dietary index for hyperinsulinemia(EDIH), the empirical lifestyle index for hyperinsulinemia(ELIH), the empirical dietary index for insulin resistance(EDIR), and the empirical lifestyle index for insulin resistance(ELIR). MAFLD was diagnosed according to the consensus definitions. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated by logistic regression. A total of 334 (49.1% boys) with mean ± SD age and BMI-for-age-Z-score of 9.3 ± 1.8 and 2.55 ± 0.69, respectively, were enrolled. After adjusting for all potential confounders, participants in the highest quartile of ELIH score had greater odds of developing MAFLD (OR:3.50;95%CI:1.49–8.22) compared with those in the lowest quartile. This association remained significant among boys and pubertal ones. However, no significant association between EDIH, EDIR, or ELIR and odds of MAFLD was found. Our study suggests that the collective insulinemic potential of dietary intake, BMI, and physical activity is associated with increased odds of MAFLD.https://doi.org/10.1038/s41598-025-88969-3Dietary and lifestyle indices for hyperinsulinemiaMetabolic dysfunction-associated fatty liver diseaseChildrenAdolescents |
| spellingShingle | Ali Nikparast Maryam Razavi Parmis Mirzaei Pooneh Dehghan Mahdi Amani Farani Golaleh Asghari Dietary and lifestyle indices for hyperinsulinemia and odds of MAFLD in overweight and obese children and adolescents Scientific Reports Dietary and lifestyle indices for hyperinsulinemia Metabolic dysfunction-associated fatty liver disease Children Adolescents |
| title | Dietary and lifestyle indices for hyperinsulinemia and odds of MAFLD in overweight and obese children and adolescents |
| title_full | Dietary and lifestyle indices for hyperinsulinemia and odds of MAFLD in overweight and obese children and adolescents |
| title_fullStr | Dietary and lifestyle indices for hyperinsulinemia and odds of MAFLD in overweight and obese children and adolescents |
| title_full_unstemmed | Dietary and lifestyle indices for hyperinsulinemia and odds of MAFLD in overweight and obese children and adolescents |
| title_short | Dietary and lifestyle indices for hyperinsulinemia and odds of MAFLD in overweight and obese children and adolescents |
| title_sort | dietary and lifestyle indices for hyperinsulinemia and odds of mafld in overweight and obese children and adolescents |
| topic | Dietary and lifestyle indices for hyperinsulinemia Metabolic dysfunction-associated fatty liver disease Children Adolescents |
| url | https://doi.org/10.1038/s41598-025-88969-3 |
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