Risk factors for and incidence of osteoporosis in patients with breast cancer by gender : a nationwide cohort study
Abstract Osteoporosis is common in breast cancer patients, but gender-specific research on its incidence and risk factors is limited. This study examined the incidence and risk of osteoporosis in male and female breast cancer patients and analyzed the risk factors for fractures. This nationwide retr...
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Nature Portfolio
2025-02-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-025-89059-0 |
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| author | Jin Ah Lee Hye Sun Lee Soyoung Jeon Dooreh Kim YoungJoo Lee SooYun Bae Woo-Chan Park Chang Ik Yoon |
| author_facet | Jin Ah Lee Hye Sun Lee Soyoung Jeon Dooreh Kim YoungJoo Lee SooYun Bae Woo-Chan Park Chang Ik Yoon |
| author_sort | Jin Ah Lee |
| collection | DOAJ |
| description | Abstract Osteoporosis is common in breast cancer patients, but gender-specific research on its incidence and risk factors is limited. This study examined the incidence and risk of osteoporosis in male and female breast cancer patients and analyzed the risk factors for fractures. This nationwide retrospective cohort study used data from the Korean National Insurance database, identifying invasive breast cancer patients from January 2009 to December 2015.Overall, 80,661 participants (299 males ; 80,362 females) were included. Matching was performed at a 1:5 ratio, based on age, treatment modalities and Charlson Comorbidity Index scores [CCI], resulting in 294 males and 1,470 females.Before and after matching, females consistently showed higher osteoporosis prevalence than males (16.7% vs. 5.0% before, 27.6% vs. 4.8% after, p < 0.001). Before matching, hip or vertebral fractures incidence showed no difference (1.2% vs. 1.3%, p = 0.789), but after matching, a significant difference was observed. (4.0% vs. 1.0%, p = 0.011). Endocrine therapy increased osteoporosis risk, particularly among females (hazard ratio [HR], 6.37; 95% confidence interval [CI], 3.74–10.89; p < 0.001). Age, steroid use, and CCI score were significant risk factors for osteoporosis. Adjusting for other variables, females with osteoporosis had a higher hip or vertebral fracture risk than males (HR, 3.96; 95% CI, 1.24–12.64; p = 0.020). Our study highlights gender-specific risks for osteoporosis and fractures in breast cancer patients, contributing to a comprehensive understanding for improving long-term outcomes and quality of life in survivors. |
| format | Article |
| id | doaj-art-0d73c31690d14cf1b9a74ed3a8ed6135 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-0d73c31690d14cf1b9a74ed3a8ed61352025-02-09T12:37:44ZengNature PortfolioScientific Reports2045-23222025-02-0115111010.1038/s41598-025-89059-0Risk factors for and incidence of osteoporosis in patients with breast cancer by gender : a nationwide cohort studyJin Ah Lee0Hye Sun Lee1Soyoung Jeon2Dooreh Kim3YoungJoo Lee4SooYun Bae5Woo-Chan Park6Chang Ik Yoon7Division of Breast Surgery, Department of Surgery, Seoul St Mary’s Hospital, College of Medicine, The Catholic University of KoreaBiostatistics Collaboration Unit, Yonsei University College of MedicineBiostatistics Collaboration Unit, Yonsei University College of MedicineDivision of Breast Surgery, Department of Surgery, Seoul St Mary’s Hospital, College of Medicine, The Catholic University of KoreaDivision of Breast Surgery, Department of Surgery, Seoul St Mary’s Hospital, College of Medicine, The Catholic University of KoreaDivision of Breast Surgery, Department of Surgery, Seoul St Mary’s Hospital, College of Medicine, The Catholic University of KoreaDivision of Breast Surgery, Department of Surgery, Seoul St Mary’s Hospital, College of Medicine, The Catholic University of KoreaDivision of Breast Surgery, Department of Surgery, Seoul St Mary’s Hospital, College of Medicine, The Catholic University of KoreaAbstract Osteoporosis is common in breast cancer patients, but gender-specific research on its incidence and risk factors is limited. This study examined the incidence and risk of osteoporosis in male and female breast cancer patients and analyzed the risk factors for fractures. This nationwide retrospective cohort study used data from the Korean National Insurance database, identifying invasive breast cancer patients from January 2009 to December 2015.Overall, 80,661 participants (299 males ; 80,362 females) were included. Matching was performed at a 1:5 ratio, based on age, treatment modalities and Charlson Comorbidity Index scores [CCI], resulting in 294 males and 1,470 females.Before and after matching, females consistently showed higher osteoporosis prevalence than males (16.7% vs. 5.0% before, 27.6% vs. 4.8% after, p < 0.001). Before matching, hip or vertebral fractures incidence showed no difference (1.2% vs. 1.3%, p = 0.789), but after matching, a significant difference was observed. (4.0% vs. 1.0%, p = 0.011). Endocrine therapy increased osteoporosis risk, particularly among females (hazard ratio [HR], 6.37; 95% confidence interval [CI], 3.74–10.89; p < 0.001). Age, steroid use, and CCI score were significant risk factors for osteoporosis. Adjusting for other variables, females with osteoporosis had a higher hip or vertebral fracture risk than males (HR, 3.96; 95% CI, 1.24–12.64; p = 0.020). Our study highlights gender-specific risks for osteoporosis and fractures in breast cancer patients, contributing to a comprehensive understanding for improving long-term outcomes and quality of life in survivors.https://doi.org/10.1038/s41598-025-89059-0 |
| spellingShingle | Jin Ah Lee Hye Sun Lee Soyoung Jeon Dooreh Kim YoungJoo Lee SooYun Bae Woo-Chan Park Chang Ik Yoon Risk factors for and incidence of osteoporosis in patients with breast cancer by gender : a nationwide cohort study Scientific Reports |
| title | Risk factors for and incidence of osteoporosis in patients with breast cancer by gender : a nationwide cohort study |
| title_full | Risk factors for and incidence of osteoporosis in patients with breast cancer by gender : a nationwide cohort study |
| title_fullStr | Risk factors for and incidence of osteoporosis in patients with breast cancer by gender : a nationwide cohort study |
| title_full_unstemmed | Risk factors for and incidence of osteoporosis in patients with breast cancer by gender : a nationwide cohort study |
| title_short | Risk factors for and incidence of osteoporosis in patients with breast cancer by gender : a nationwide cohort study |
| title_sort | risk factors for and incidence of osteoporosis in patients with breast cancer by gender a nationwide cohort study |
| url | https://doi.org/10.1038/s41598-025-89059-0 |
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