Case of angioimmunoblastic T-cell lymphoma presenting as peripheral and bone marrow plasmacytosis: A diagnostic conundrum
Angioimmunoblastic T-cell lymphoma (AITL), a subtype of peripheral T-cell lymphoma (PTCL), is associated with unique clinical, morphological, and immunohistochemical features. The peripheral circulation might show presence of an occasional reactive plasma cell but significant plasmacytosis masquerad...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2024-04-01
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| Series: | Indian Journal of Pathology and Microbiology |
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| Online Access: | https://journals.lww.com/10.4103/ijpm.ijpm_277_22 |
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| author | Deepika Gupta Nagarjun S. Jaine Sandeep K. Bairwa Balamurugan Thirunavukkarasu Vikarn Vishwajeet Abhishek H. L. Purohit |
| author_facet | Deepika Gupta Nagarjun S. Jaine Sandeep K. Bairwa Balamurugan Thirunavukkarasu Vikarn Vishwajeet Abhishek H. L. Purohit |
| author_sort | Deepika Gupta |
| collection | DOAJ |
| description | Angioimmunoblastic T-cell lymphoma (AITL), a subtype of peripheral T-cell lymphoma (PTCL), is associated with unique clinical, morphological, and immunohistochemical features. The peripheral circulation might show presence of an occasional reactive plasma cell but significant plasmacytosis masquerading as plasma cell leukemia is rare. We report a case of AITL in a 42-year-old male, who presented with two-month history of generalized lymphadenopathy. On investigations, he had hypergammaglobulinemia and plasmacytosis in the peripheral blood and bone marrow masquerading as plasma cell leukemia. Immunohistochemistry and serum protein electrophoresis revealed polyclonal nature of plasma cells. Diagnosis of AITL was made on cervical lymph node biopsy. This case highlights the diagnostic challenge faced due to heterogeneity in the clinical presentation and pathological findings and to alert the clinician so that timely accurate diagnosis can be made to initiate the treatment. |
| format | Article |
| id | doaj-art-0e1dd8cbaa8e40da93ad3d59b0bace99 |
| institution | Kabale University |
| issn | 0377-4929 0974-5130 |
| language | English |
| publishDate | 2024-04-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Pathology and Microbiology |
| spelling | doaj-art-0e1dd8cbaa8e40da93ad3d59b0bace992025-02-07T14:01:27ZengWolters Kluwer Medknow PublicationsIndian Journal of Pathology and Microbiology0377-49290974-51302024-04-0167245245510.4103/ijpm.ijpm_277_22Case of angioimmunoblastic T-cell lymphoma presenting as peripheral and bone marrow plasmacytosis: A diagnostic conundrumDeepika GuptaNagarjun S. JaineSandeep K. BairwaBalamurugan ThirunavukkarasuVikarn VishwajeetAbhishek H. L. PurohitAngioimmunoblastic T-cell lymphoma (AITL), a subtype of peripheral T-cell lymphoma (PTCL), is associated with unique clinical, morphological, and immunohistochemical features. The peripheral circulation might show presence of an occasional reactive plasma cell but significant plasmacytosis masquerading as plasma cell leukemia is rare. We report a case of AITL in a 42-year-old male, who presented with two-month history of generalized lymphadenopathy. On investigations, he had hypergammaglobulinemia and plasmacytosis in the peripheral blood and bone marrow masquerading as plasma cell leukemia. Immunohistochemistry and serum protein electrophoresis revealed polyclonal nature of plasma cells. Diagnosis of AITL was made on cervical lymph node biopsy. This case highlights the diagnostic challenge faced due to heterogeneity in the clinical presentation and pathological findings and to alert the clinician so that timely accurate diagnosis can be made to initiate the treatment.https://journals.lww.com/10.4103/ijpm.ijpm_277_22angioimmunoblastic t-cell lymphomaperipheral bloodplasmacytosis |
| spellingShingle | Deepika Gupta Nagarjun S. Jaine Sandeep K. Bairwa Balamurugan Thirunavukkarasu Vikarn Vishwajeet Abhishek H. L. Purohit Case of angioimmunoblastic T-cell lymphoma presenting as peripheral and bone marrow plasmacytosis: A diagnostic conundrum Indian Journal of Pathology and Microbiology angioimmunoblastic t-cell lymphoma peripheral blood plasmacytosis |
| title | Case of angioimmunoblastic T-cell lymphoma presenting as peripheral and bone marrow plasmacytosis: A diagnostic conundrum |
| title_full | Case of angioimmunoblastic T-cell lymphoma presenting as peripheral and bone marrow plasmacytosis: A diagnostic conundrum |
| title_fullStr | Case of angioimmunoblastic T-cell lymphoma presenting as peripheral and bone marrow plasmacytosis: A diagnostic conundrum |
| title_full_unstemmed | Case of angioimmunoblastic T-cell lymphoma presenting as peripheral and bone marrow plasmacytosis: A diagnostic conundrum |
| title_short | Case of angioimmunoblastic T-cell lymphoma presenting as peripheral and bone marrow plasmacytosis: A diagnostic conundrum |
| title_sort | case of angioimmunoblastic t cell lymphoma presenting as peripheral and bone marrow plasmacytosis a diagnostic conundrum |
| topic | angioimmunoblastic t-cell lymphoma peripheral blood plasmacytosis |
| url | https://journals.lww.com/10.4103/ijpm.ijpm_277_22 |
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