Effect of platelet-rich plasma on angiogenic and regenerative properties in patients with critical limb ischemia
Platelet-rich plasma (PRP) is a promising regenerative therapy due to its simplicity, clinical application, safety, and ability to promote angiogenesis. It utilizes various angiogenic growth factors in platelets, including platelet-derived growth factor (PDGF), transforming growth factor-β (TGF-β),...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-03-01
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| Series: | Regenerative Therapy |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352320425000082 |
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| author | Hamid Tanzadehpanah Sima Nobari Ava Jalalian Hoseini Farzaneh Ghotbani Mohsen Mehrabzadeh Jamal Jalili shahri Amirreza Alipour Mohsen Sheykhhasan Hamed Manoochehri Susan Darroudi Hanie Mahaki |
| author_facet | Hamid Tanzadehpanah Sima Nobari Ava Jalalian Hoseini Farzaneh Ghotbani Mohsen Mehrabzadeh Jamal Jalili shahri Amirreza Alipour Mohsen Sheykhhasan Hamed Manoochehri Susan Darroudi Hanie Mahaki |
| author_sort | Hamid Tanzadehpanah |
| collection | DOAJ |
| description | Platelet-rich plasma (PRP) is a promising regenerative therapy due to its simplicity, clinical application, safety, and ability to promote angiogenesis. It utilizes various angiogenic growth factors in platelets, including platelet-derived growth factor (PDGF), transforming growth factor-β (TGF-β), insulin-like growth factor-1 (IGF-1), vascular endothelial growth factor (VEGF), and epidermal growth factor (EGF), which are integral to the tissue repair.Critical limb ischemia (CLI) is a major symptom of peripheral arterial disease (PAD), and PRP therapy aims to improve blood circulation to the distal limb through the development of blood vessels. This review focuses on the extensive research on the molecular mechanisms of PRPs in treating CLI. A comprehensive search was conducted on Web of Science, PubMed, Google Scholar, and Scopus to find studies published during PRP therapy in critical limb ischemia up to June 2024. Current studies reveal that PRP composition varies by case, affecting preparation methods, storage duration, storage methods, and interaction with other materials. PRP-derived growth factors have shown promising results in treating CLI, but well-controlled human research is scarce despite positive animal studies. |
| format | Article |
| id | doaj-art-0e229895261f41818dfa756957ef753e |
| institution | Kabale University |
| issn | 2352-3204 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Regenerative Therapy |
| spelling | doaj-art-0e229895261f41818dfa756957ef753e2025-02-07T04:47:45ZengElsevierRegenerative Therapy2352-32042025-03-0128517526Effect of platelet-rich plasma on angiogenic and regenerative properties in patients with critical limb ischemiaHamid Tanzadehpanah0Sima Nobari1Ava Jalalian Hoseini2Farzaneh Ghotbani3Mohsen Mehrabzadeh4Jamal Jalili shahri5Amirreza Alipour6Mohsen Sheykhhasan7Hamed Manoochehri8Susan Darroudi9Hanie Mahaki10Antimicrobial Resistance Research Center, Basic Science Research Institute, Mashhad University of Medical Sciences, Mashhad, Iran; Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, IranDeputy of Health, Iran University of Medical Science, Tehran, IranResearch Committee, Mashhad University of Medical Sciences, Mashhad, IranResearch Committee, Mashhad University of Medical Sciences, Mashhad, IranVascular and Endovascular Surgery Research Center, Mashhad University of Medical Sciences, Mashhad, IranVascular and Endovascular Surgery Research Center, Mashhad University of Medical Sciences, Mashhad, IranVascular and Endovascular Surgery Research Center, Mashhad University of Medical Sciences, Mashhad, IranCellular and Molecular Research Center, Qom University of Medical Sciences, Qom, IranThe Persian Gulf Marine Biotechnology Research Center, The Persian Gulf Biomedical Sciences Research Institute, Bushehr University of Medical Sciences, Bushehr, IranVascular and Endovascular Surgery Research Center, Mashhad University of Medical Sciences, Mashhad, IranVascular and Endovascular Surgery Research Center, Mashhad University of Medical Sciences, Mashhad, Iran; Corresponding author.Platelet-rich plasma (PRP) is a promising regenerative therapy due to its simplicity, clinical application, safety, and ability to promote angiogenesis. It utilizes various angiogenic growth factors in platelets, including platelet-derived growth factor (PDGF), transforming growth factor-β (TGF-β), insulin-like growth factor-1 (IGF-1), vascular endothelial growth factor (VEGF), and epidermal growth factor (EGF), which are integral to the tissue repair.Critical limb ischemia (CLI) is a major symptom of peripheral arterial disease (PAD), and PRP therapy aims to improve blood circulation to the distal limb through the development of blood vessels. This review focuses on the extensive research on the molecular mechanisms of PRPs in treating CLI. A comprehensive search was conducted on Web of Science, PubMed, Google Scholar, and Scopus to find studies published during PRP therapy in critical limb ischemia up to June 2024. Current studies reveal that PRP composition varies by case, affecting preparation methods, storage duration, storage methods, and interaction with other materials. PRP-derived growth factors have shown promising results in treating CLI, but well-controlled human research is scarce despite positive animal studies.http://www.sciencedirect.com/science/article/pii/S2352320425000082Platelet-rich plasmaAngiogenic factorGrowth factorCritical limb ischemiaPeripheral arterial disease |
| spellingShingle | Hamid Tanzadehpanah Sima Nobari Ava Jalalian Hoseini Farzaneh Ghotbani Mohsen Mehrabzadeh Jamal Jalili shahri Amirreza Alipour Mohsen Sheykhhasan Hamed Manoochehri Susan Darroudi Hanie Mahaki Effect of platelet-rich plasma on angiogenic and regenerative properties in patients with critical limb ischemia Regenerative Therapy Platelet-rich plasma Angiogenic factor Growth factor Critical limb ischemia Peripheral arterial disease |
| title | Effect of platelet-rich plasma on angiogenic and regenerative properties in patients with critical limb ischemia |
| title_full | Effect of platelet-rich plasma on angiogenic and regenerative properties in patients with critical limb ischemia |
| title_fullStr | Effect of platelet-rich plasma on angiogenic and regenerative properties in patients with critical limb ischemia |
| title_full_unstemmed | Effect of platelet-rich plasma on angiogenic and regenerative properties in patients with critical limb ischemia |
| title_short | Effect of platelet-rich plasma on angiogenic and regenerative properties in patients with critical limb ischemia |
| title_sort | effect of platelet rich plasma on angiogenic and regenerative properties in patients with critical limb ischemia |
| topic | Platelet-rich plasma Angiogenic factor Growth factor Critical limb ischemia Peripheral arterial disease |
| url | http://www.sciencedirect.com/science/article/pii/S2352320425000082 |
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