The clinical role of blood coagulation and platelet receptors gene allelic variants in development of cryoglobulinemic vasculitis at chronic hepatitis C
Aim of investigation. To estimate the clinical and prognostic value of carriage of various blood coagulation and platelet receptors gene allelic variants in development of cryoglobulinemic vasculitis at chronic hepatitis C (CHC). Material and methods. Original study included overall 200 patients wit...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
Gastro LLC
2018-08-01
|
| Series: | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
| Subjects: | |
| Online Access: | https://www.gastro-j.ru/jour/article/view/81 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1823860254364925952 |
|---|---|
| author | Yekaterina Ye. Starostina M. V. Sokolova L. M. Samokhodskaya T. П. Rozina T. N. Krasnova Ye. B. Yarovaya N. A. Mukhin |
| author_facet | Yekaterina Ye. Starostina M. V. Sokolova L. M. Samokhodskaya T. П. Rozina T. N. Krasnova Ye. B. Yarovaya N. A. Mukhin |
| author_sort | Yekaterina Ye. Starostina |
| collection | DOAJ |
| description | Aim of investigation. To estimate the clinical and prognostic value of carriage of various blood coagulation and platelet receptors gene allelic variants in development of cryoglobulinemic vasculitis at chronic hepatitis C (CHC). Material and methods. Original study included overall 200 patients with CHCs and liver cirrhosis in its outcome, who were divided into 3 groups: patients without cryoglobulinemia (CG, n=123), those with asymptomatic cryoglobulinemia (ACG, n=40) and with cryoglobulinemic vasculitis (CGV, n=37). Assessment of polymorphism of the studied genes was carried out by real-time polymerase chain reaction with melting curve analysis. Results. CGV patients in comparison to those with ACG had 4G mutant allele are significantly more frequent (odds ratio (OR): 4G=2,008) as well as genotypes 5G4G+4G4G (OR: 5G4G+4G4G=4,950) of the gene PAI-675 5G/4G, and in comparison to patients without CG - CC mutant genotype of the gene ITGB3 1565 T/C (р =0,047). The multifactor analysis at comparison of patients with CGV and without it revealed the quantity of mutant alleles of PAI-675 5G/4G and ITGB3 1565 T/C genes and infection duration as independent factors for vasculitis development, while at comparison of patients with CGV and ACG - only quantity of mutant alleles of these genes. Patients with CGV allele C and CC homozygosity of the gene ITGB3 1565 T/C is associated to presence of renal diseases, while allele C genotypes (TC+CC) of ITGB3 1565 T/C gene is associated with involvement of muscular and nervous system. Conclusion. Carriage of mutant genotypes of PAI-675 5G/4G and ITGB3 1565 T/C genes is a factor which allows to predict CGV development in CHC patients, and can determine clinical manifestations of the latter. |
| format | Article |
| id | doaj-art-0e31c624230d42dc94bf6388a5e97c5f |
| institution | Kabale University |
| issn | 1382-4376 2658-6673 |
| language | Russian |
| publishDate | 2018-08-01 |
| publisher | Gastro LLC |
| record_format | Article |
| series | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
| spelling | doaj-art-0e31c624230d42dc94bf6388a5e97c5f2025-02-10T16:14:28ZrusGastro LLCРоссийский журнал гастроэнтерологии, гепатологии, колопроктологии1382-43762658-66732018-08-01265283510.22416/1382-4376-2016-5-28-3581The clinical role of blood coagulation and platelet receptors gene allelic variants in development of cryoglobulinemic vasculitis at chronic hepatitis CYekaterina Ye. Starostina0M. V. Sokolova1L. M. Samokhodskaya2T. П. Rozina3T. N. Krasnova4Ye. B. Yarovaya5N. A. Mukhin6Federal state educational government-financed institution of higher education «Lomonosov Moscow State University»Federal state educational government-financed institution of higher education «Lomonosov Moscow State University»Federal state educational government-financed institution of higher education «Lomonosov Moscow State University»Federal state educational government-financed institution of higher education «Lomonosov Moscow State University»; Federal state educational government-financed institution of higher education «Sechenov First Moscow state medical university»Federal state educational government-financed institution of higher education «Lomonosov Moscow State University»; Federal state educational government-financed institution of higher education «Sechenov First Moscow state medical university»Federal state educational government-financed institution of higher education «Lomonosov Moscow State University»Federal state educational government-financed institution of higher education «Lomonosov Moscow State University»; Federal state educational government-financed institution of higher education «Sechenov First Moscow state medical university»Aim of investigation. To estimate the clinical and prognostic value of carriage of various blood coagulation and platelet receptors gene allelic variants in development of cryoglobulinemic vasculitis at chronic hepatitis C (CHC). Material and methods. Original study included overall 200 patients with CHCs and liver cirrhosis in its outcome, who were divided into 3 groups: patients without cryoglobulinemia (CG, n=123), those with asymptomatic cryoglobulinemia (ACG, n=40) and with cryoglobulinemic vasculitis (CGV, n=37). Assessment of polymorphism of the studied genes was carried out by real-time polymerase chain reaction with melting curve analysis. Results. CGV patients in comparison to those with ACG had 4G mutant allele are significantly more frequent (odds ratio (OR): 4G=2,008) as well as genotypes 5G4G+4G4G (OR: 5G4G+4G4G=4,950) of the gene PAI-675 5G/4G, and in comparison to patients without CG - CC mutant genotype of the gene ITGB3 1565 T/C (р =0,047). The multifactor analysis at comparison of patients with CGV and without it revealed the quantity of mutant alleles of PAI-675 5G/4G and ITGB3 1565 T/C genes and infection duration as independent factors for vasculitis development, while at comparison of patients with CGV and ACG - only quantity of mutant alleles of these genes. Patients with CGV allele C and CC homozygosity of the gene ITGB3 1565 T/C is associated to presence of renal diseases, while allele C genotypes (TC+CC) of ITGB3 1565 T/C gene is associated with involvement of muscular and nervous system. Conclusion. Carriage of mutant genotypes of PAI-675 5G/4G and ITGB3 1565 T/C genes is a factor which allows to predict CGV development in CHC patients, and can determine clinical manifestations of the latter.https://www.gastro-j.ru/jour/article/view/81хронический гепатит скрио-глобулинемический васкулитполиморфизм геновтромбофилиягемостазтромбоцитарные рецепто-ры |
| spellingShingle | Yekaterina Ye. Starostina M. V. Sokolova L. M. Samokhodskaya T. П. Rozina T. N. Krasnova Ye. B. Yarovaya N. A. Mukhin The clinical role of blood coagulation and platelet receptors gene allelic variants in development of cryoglobulinemic vasculitis at chronic hepatitis C Российский журнал гастроэнтерологии, гепатологии, колопроктологии хронический гепатит с крио-глобулинемический васкулит полиморфизм генов тромбофилия гемостаз тромбоцитарные рецепто-ры |
| title | The clinical role of blood coagulation and platelet receptors gene allelic variants in development of cryoglobulinemic vasculitis at chronic hepatitis C |
| title_full | The clinical role of blood coagulation and platelet receptors gene allelic variants in development of cryoglobulinemic vasculitis at chronic hepatitis C |
| title_fullStr | The clinical role of blood coagulation and platelet receptors gene allelic variants in development of cryoglobulinemic vasculitis at chronic hepatitis C |
| title_full_unstemmed | The clinical role of blood coagulation and platelet receptors gene allelic variants in development of cryoglobulinemic vasculitis at chronic hepatitis C |
| title_short | The clinical role of blood coagulation and platelet receptors gene allelic variants in development of cryoglobulinemic vasculitis at chronic hepatitis C |
| title_sort | clinical role of blood coagulation and platelet receptors gene allelic variants in development of cryoglobulinemic vasculitis at chronic hepatitis c |
| topic | хронический гепатит с крио-глобулинемический васкулит полиморфизм генов тромбофилия гемостаз тромбоцитарные рецепто-ры |
| url | https://www.gastro-j.ru/jour/article/view/81 |
| work_keys_str_mv | AT yekaterinayestarostina theclinicalroleofbloodcoagulationandplateletreceptorsgeneallelicvariantsindevelopmentofcryoglobulinemicvasculitisatchronichepatitisc AT mvsokolova theclinicalroleofbloodcoagulationandplateletreceptorsgeneallelicvariantsindevelopmentofcryoglobulinemicvasculitisatchronichepatitisc AT lmsamokhodskaya theclinicalroleofbloodcoagulationandplateletreceptorsgeneallelicvariantsindevelopmentofcryoglobulinemicvasculitisatchronichepatitisc AT tprozina theclinicalroleofbloodcoagulationandplateletreceptorsgeneallelicvariantsindevelopmentofcryoglobulinemicvasculitisatchronichepatitisc AT tnkrasnova theclinicalroleofbloodcoagulationandplateletreceptorsgeneallelicvariantsindevelopmentofcryoglobulinemicvasculitisatchronichepatitisc AT yebyarovaya theclinicalroleofbloodcoagulationandplateletreceptorsgeneallelicvariantsindevelopmentofcryoglobulinemicvasculitisatchronichepatitisc AT namukhin theclinicalroleofbloodcoagulationandplateletreceptorsgeneallelicvariantsindevelopmentofcryoglobulinemicvasculitisatchronichepatitisc AT yekaterinayestarostina clinicalroleofbloodcoagulationandplateletreceptorsgeneallelicvariantsindevelopmentofcryoglobulinemicvasculitisatchronichepatitisc AT mvsokolova clinicalroleofbloodcoagulationandplateletreceptorsgeneallelicvariantsindevelopmentofcryoglobulinemicvasculitisatchronichepatitisc AT lmsamokhodskaya clinicalroleofbloodcoagulationandplateletreceptorsgeneallelicvariantsindevelopmentofcryoglobulinemicvasculitisatchronichepatitisc AT tprozina clinicalroleofbloodcoagulationandplateletreceptorsgeneallelicvariantsindevelopmentofcryoglobulinemicvasculitisatchronichepatitisc AT tnkrasnova clinicalroleofbloodcoagulationandplateletreceptorsgeneallelicvariantsindevelopmentofcryoglobulinemicvasculitisatchronichepatitisc AT yebyarovaya clinicalroleofbloodcoagulationandplateletreceptorsgeneallelicvariantsindevelopmentofcryoglobulinemicvasculitisatchronichepatitisc AT namukhin clinicalroleofbloodcoagulationandplateletreceptorsgeneallelicvariantsindevelopmentofcryoglobulinemicvasculitisatchronichepatitisc |