Management of eight cases of subarachnoid hemorrhage using transpulmonary thermodilution during clazosentan therapy
Clazosentan, an endothelin receptor antagonist, is used to prevent delayed neurological deterioration in patients with subarachnoid hemorrhage due to ruptured cerebral aneurysms. However, fluid management presents challenges. This single-center case series presents the findings from eight patients u...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-03-01
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| Series: | Interdisciplinary Neurosurgery |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S221475192500009X |
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| author | Hiroto Iyota Yasumasa Kawano Hironori Fukumoto Takato Tajiri Mitsutoshi Iwaasa Sinichi Morimoto Yoshito Izutani Shintaro Yamasaki Kazuya Yamauchi Hiroki Hatomoto Hiroshi Abe Yoshihiko Nakamura |
| author_facet | Hiroto Iyota Yasumasa Kawano Hironori Fukumoto Takato Tajiri Mitsutoshi Iwaasa Sinichi Morimoto Yoshito Izutani Shintaro Yamasaki Kazuya Yamauchi Hiroki Hatomoto Hiroshi Abe Yoshihiko Nakamura |
| author_sort | Hiroto Iyota |
| collection | DOAJ |
| description | Clazosentan, an endothelin receptor antagonist, is used to prevent delayed neurological deterioration in patients with subarachnoid hemorrhage due to ruptured cerebral aneurysms. However, fluid management presents challenges. This single-center case series presents the findings from eight patients undergoing fluid management using transpulmonary thermodilution while receiving clazosentan. The median age of the patients was 49 years (interquartile range: 45.5–63.5), and four (50 %) were male. The median World Federation of Neurosurgical Societies classification was 5 (interquartile range: 2–5), and the median Fisher classification was 3 (interquartile range: 3). During clazosentan treatment, the median global end-diastolic volume index based on transpulmonary thermodilution remained at 715.5 ml/m2 (interquartile range: 643–788). No ischemic neurological deficits, bilateral pulmonary edema, and pleural effusion were observed. Strict fluid management using transpulmonary thermodilution might prevent the complications associated with clazosentan. |
| format | Article |
| id | doaj-art-0f06e0b8f5994e57b88b9385266ce512 |
| institution | Kabale University |
| issn | 2214-7519 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Interdisciplinary Neurosurgery |
| spelling | doaj-art-0f06e0b8f5994e57b88b9385266ce5122025-02-12T05:31:09ZengElsevierInterdisciplinary Neurosurgery2214-75192025-03-0139101997Management of eight cases of subarachnoid hemorrhage using transpulmonary thermodilution during clazosentan therapyHiroto Iyota0Yasumasa Kawano1Hironori Fukumoto2Takato Tajiri3Mitsutoshi Iwaasa4Sinichi Morimoto5Yoshito Izutani6Shintaro Yamasaki7Kazuya Yamauchi8Hiroki Hatomoto9Hiroshi Abe10Yoshihiko Nakamura11Department of Emergency and Critical Care Medicine, Faculty of Medicine, Fukuoka University, Fukuoka, JapanDepartment of Emergency and Critical Care Medicine, Faculty of Medicine, Fukuoka University, Fukuoka, Japan; Corresponding author at: Department of Emergency and Critical Care Medicine, Faculty of Medicine, Fukuoka University, 7-45-1 Nanakuma, Jonan-ku, Fukuoka 8140180, Japan.Department of Emergency and Critical Care Medicine, Faculty of Medicine, Fukuoka University, Fukuoka, Japan; Department of Neurosurgery, Faculty of Medicine, Fukuoka University, Fukuoka, JapanDepartment of Emergency and Critical Care Medicine, Faculty of Medicine, Fukuoka University, Fukuoka, Japan; Department of Neurosurgery, Faculty of Medicine, Fukuoka University, Fukuoka, JapanDepartment of Emergency and Critical Care Medicine, Faculty of Medicine, Fukuoka University, Fukuoka, Japan; Department of Neurosurgery, Faculty of Medicine, Fukuoka University, Fukuoka, JapanDepartment of Emergency and Critical Care Medicine, Faculty of Medicine, Fukuoka University, Fukuoka, JapanDepartment of Emergency and Critical Care Medicine, Faculty of Medicine, Fukuoka University, Fukuoka, JapanDepartment of Clinical Engineering Center, Fukuoka University Hospital, Fukuoka, JapanDepartment of Clinical Engineering Center, Fukuoka University Hospital, Fukuoka, JapanDepartment of Clinical Engineering Center, Fukuoka University Hospital, Fukuoka, JapanDepartment of Neurosurgery, Faculty of Medicine, Fukuoka University, Fukuoka, JapanDepartment of Emergency and Critical Care Medicine, Faculty of Medicine, Fukuoka University, Fukuoka, JapanClazosentan, an endothelin receptor antagonist, is used to prevent delayed neurological deterioration in patients with subarachnoid hemorrhage due to ruptured cerebral aneurysms. However, fluid management presents challenges. This single-center case series presents the findings from eight patients undergoing fluid management using transpulmonary thermodilution while receiving clazosentan. The median age of the patients was 49 years (interquartile range: 45.5–63.5), and four (50 %) were male. The median World Federation of Neurosurgical Societies classification was 5 (interquartile range: 2–5), and the median Fisher classification was 3 (interquartile range: 3). During clazosentan treatment, the median global end-diastolic volume index based on transpulmonary thermodilution remained at 715.5 ml/m2 (interquartile range: 643–788). No ischemic neurological deficits, bilateral pulmonary edema, and pleural effusion were observed. Strict fluid management using transpulmonary thermodilution might prevent the complications associated with clazosentan.http://www.sciencedirect.com/science/article/pii/S221475192500009XSubarachnoid hemorrhageClazosentanTranspulmonary thermodilutionDelayed ischemic neurological deficitCerebral vasospasmPulmonary edema |
| spellingShingle | Hiroto Iyota Yasumasa Kawano Hironori Fukumoto Takato Tajiri Mitsutoshi Iwaasa Sinichi Morimoto Yoshito Izutani Shintaro Yamasaki Kazuya Yamauchi Hiroki Hatomoto Hiroshi Abe Yoshihiko Nakamura Management of eight cases of subarachnoid hemorrhage using transpulmonary thermodilution during clazosentan therapy Interdisciplinary Neurosurgery Subarachnoid hemorrhage Clazosentan Transpulmonary thermodilution Delayed ischemic neurological deficit Cerebral vasospasm Pulmonary edema |
| title | Management of eight cases of subarachnoid hemorrhage using transpulmonary thermodilution during clazosentan therapy |
| title_full | Management of eight cases of subarachnoid hemorrhage using transpulmonary thermodilution during clazosentan therapy |
| title_fullStr | Management of eight cases of subarachnoid hemorrhage using transpulmonary thermodilution during clazosentan therapy |
| title_full_unstemmed | Management of eight cases of subarachnoid hemorrhage using transpulmonary thermodilution during clazosentan therapy |
| title_short | Management of eight cases of subarachnoid hemorrhage using transpulmonary thermodilution during clazosentan therapy |
| title_sort | management of eight cases of subarachnoid hemorrhage using transpulmonary thermodilution during clazosentan therapy |
| topic | Subarachnoid hemorrhage Clazosentan Transpulmonary thermodilution Delayed ischemic neurological deficit Cerebral vasospasm Pulmonary edema |
| url | http://www.sciencedirect.com/science/article/pii/S221475192500009X |
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