Nerve root magnetic stimulation regulates the synaptic plasticity of injured spinal cord by ascending sensory pathway
Promoting synaptic plasticity and inducing functional reorganization of residual nerve fibers hold clinical significance for restoring motor function following spinal cord injury. Neuromagnetic stimulation targeting the nerve roots has been shown to improve motor function by enhancing nerve conducti...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2025-12-01
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| Series: | Neural Regeneration Research |
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| Online Access: | https://journals.lww.com/10.4103/NRR.NRR-D-24-00628 |
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| author | Ya Zheng Lingyun Cao Dan Zhao Qi Yang Chunya Gu Yeran Mao Guangyue Zhu Yulian Zhu Jing Zhao Dongsheng Xu |
| author_facet | Ya Zheng Lingyun Cao Dan Zhao Qi Yang Chunya Gu Yeran Mao Guangyue Zhu Yulian Zhu Jing Zhao Dongsheng Xu |
| author_sort | Ya Zheng |
| collection | DOAJ |
| description | Promoting synaptic plasticity and inducing functional reorganization of residual nerve fibers hold clinical significance for restoring motor function following spinal cord injury. Neuromagnetic stimulation targeting the nerve roots has been shown to improve motor function by enhancing nerve conduction in the injured spinal cord and restoring the synaptic ultrastructure of both the sensory and motor cortex. However, our understanding of the neurophysiological mechanisms by which nerve root magnetic stimulation facilitates motor function recovery in the spinal cord is limited, and its role in neuroplasticity remains unclear. In this study, we established a model of spinal cord injury in adult male Sprague–Dawley rats by applying moderate compression at the T10 vertebra. We then performed magnetic stimulation on the L5 nerve root for 3 weeks, beginning on day 3 post-injury. At day 22 post-injury, we observed that nerve root magnetic stimulation downregulated the level of interleukin-6 in the injured spinal cord tissue of rats. Additionally, this treatment reduced neuronal damage and glial scar formation, and increased the number of neurons in the injured spinal cord. Furthermore, nerve root magnetic stimulation decreased the levels of acetylcholine, norepinephrine, and dopamine, and increased the expression of synaptic plasticity-related mRNA and proteins PSD95, GAP43, and Synapsin II. Taken together, these results showed that nerve root magnetic stimulation alleviated neuronal damage in the injured spinal cord, regulated synaptic plasticity, and suppressed inflammatory responses. These findings provide laboratory evidence for the clinical application of nerve root magnetic stimulation in the treatment of spinal cord injury. |
| format | Article |
| id | doaj-art-0f42ad1013c947e9b60186482779577c |
| institution | Kabale University |
| issn | 1673-5374 1876-7958 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Neural Regeneration Research |
| spelling | doaj-art-0f42ad1013c947e9b60186482779577c2025-02-06T09:58:39ZengWolters Kluwer Medknow PublicationsNeural Regeneration Research1673-53741876-79582025-12-0120123564357310.4103/NRR.NRR-D-24-00628Nerve root magnetic stimulation regulates the synaptic plasticity of injured spinal cord by ascending sensory pathwayYa ZhengLingyun CaoDan ZhaoQi YangChunya GuYeran MaoGuangyue ZhuYulian ZhuJing ZhaoDongsheng XuPromoting synaptic plasticity and inducing functional reorganization of residual nerve fibers hold clinical significance for restoring motor function following spinal cord injury. Neuromagnetic stimulation targeting the nerve roots has been shown to improve motor function by enhancing nerve conduction in the injured spinal cord and restoring the synaptic ultrastructure of both the sensory and motor cortex. However, our understanding of the neurophysiological mechanisms by which nerve root magnetic stimulation facilitates motor function recovery in the spinal cord is limited, and its role in neuroplasticity remains unclear. In this study, we established a model of spinal cord injury in adult male Sprague–Dawley rats by applying moderate compression at the T10 vertebra. We then performed magnetic stimulation on the L5 nerve root for 3 weeks, beginning on day 3 post-injury. At day 22 post-injury, we observed that nerve root magnetic stimulation downregulated the level of interleukin-6 in the injured spinal cord tissue of rats. Additionally, this treatment reduced neuronal damage and glial scar formation, and increased the number of neurons in the injured spinal cord. Furthermore, nerve root magnetic stimulation decreased the levels of acetylcholine, norepinephrine, and dopamine, and increased the expression of synaptic plasticity-related mRNA and proteins PSD95, GAP43, and Synapsin II. Taken together, these results showed that nerve root magnetic stimulation alleviated neuronal damage in the injured spinal cord, regulated synaptic plasticity, and suppressed inflammatory responses. These findings provide laboratory evidence for the clinical application of nerve root magnetic stimulation in the treatment of spinal cord injury.https://journals.lww.com/10.4103/NRR.NRR-D-24-00628dendriteinflammationmagnetic stimulationnerve rootneurological functionneuronal damageneurotransmitterspinal cord injurysynaptic plasticitysynaptic transmission |
| spellingShingle | Ya Zheng Lingyun Cao Dan Zhao Qi Yang Chunya Gu Yeran Mao Guangyue Zhu Yulian Zhu Jing Zhao Dongsheng Xu Nerve root magnetic stimulation regulates the synaptic plasticity of injured spinal cord by ascending sensory pathway Neural Regeneration Research dendrite inflammation magnetic stimulation nerve root neurological function neuronal damage neurotransmitter spinal cord injury synaptic plasticity synaptic transmission |
| title | Nerve root magnetic stimulation regulates the synaptic plasticity of injured spinal cord by ascending sensory pathway |
| title_full | Nerve root magnetic stimulation regulates the synaptic plasticity of injured spinal cord by ascending sensory pathway |
| title_fullStr | Nerve root magnetic stimulation regulates the synaptic plasticity of injured spinal cord by ascending sensory pathway |
| title_full_unstemmed | Nerve root magnetic stimulation regulates the synaptic plasticity of injured spinal cord by ascending sensory pathway |
| title_short | Nerve root magnetic stimulation regulates the synaptic plasticity of injured spinal cord by ascending sensory pathway |
| title_sort | nerve root magnetic stimulation regulates the synaptic plasticity of injured spinal cord by ascending sensory pathway |
| topic | dendrite inflammation magnetic stimulation nerve root neurological function neuronal damage neurotransmitter spinal cord injury synaptic plasticity synaptic transmission |
| url | https://journals.lww.com/10.4103/NRR.NRR-D-24-00628 |
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