Tecovirimat in the management of poxviruses: a narrative review of available evidence
Abstract Introduction Tecovirimat (TPOXX) is an effective antiviral medication recommended for treating smallpox and other Orthopoxvirus infections. With the rise in monkeypox (mpox) cases globally, there is an urgent need to explore therapeutic options to manage potential outbreaks. Methodology A l...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2025-02-01
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| Series: | The Egyptian Journal of Internal Medicine |
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| Online Access: | https://doi.org/10.1186/s43162-025-00401-4 |
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| author | Olalekan John Okesanya Jerico Bautista Ogaya Ikponmwosa Jude Ogieuhi Mohamed Mustaf Ahmed Bonaventure Michael Ukoaka Ojoisimi Franca Jamgbadi Deborah Oluwaseun Shomuyiwa Don Lucero-Prisno Eliseo Blessing Olawunmi Amisu Olakulehin Adebusuyi William K. Chung Emery Manirambona Nimat Bola Idris Janet Alexis A. De los Santos |
| author_facet | Olalekan John Okesanya Jerico Bautista Ogaya Ikponmwosa Jude Ogieuhi Mohamed Mustaf Ahmed Bonaventure Michael Ukoaka Ojoisimi Franca Jamgbadi Deborah Oluwaseun Shomuyiwa Don Lucero-Prisno Eliseo Blessing Olawunmi Amisu Olakulehin Adebusuyi William K. Chung Emery Manirambona Nimat Bola Idris Janet Alexis A. De los Santos |
| author_sort | Olalekan John Okesanya |
| collection | DOAJ |
| description | Abstract Introduction Tecovirimat (TPOXX) is an effective antiviral medication recommended for treating smallpox and other Orthopoxvirus infections. With the rise in monkeypox (mpox) cases globally, there is an urgent need to explore therapeutic options to manage potential outbreaks. Methodology A literature search was conducted using keywords from Scopus and ClinicalTrials.gov. English studies from 2018 to 2024 were included. Results Ten studies assessing the effectiveness and safety of tecovirimat for poxvirus infections were evaluated, reporting diverse findings across different patient populations and study designs. Clinical trials have shown significant therapeutic potential. Various doses of tecovirimat were used in rabbit and mpox models. Early intervention slowed disease progression in vulnerable populations, such as people living with HIV (PLWHIV). Recovery times, virus eradication, and symptom relief varied among studies, but wider access and usage showed better clinical symptoms and tolerable side effects. Tecovirimat’s efficacy against circulating strains has been experimentally demonstrated. Conclusion Tecovirimat shows promise for treating poxvirus infections. Clinical trials are expected to provide more evidence-based findings to inform future therapeutic approaches and public health campaigns. Future research should explore tecovirimat’s potential in managing emerging poxvirus outbreaks, such as borealpox and mpox, to strengthen and promote public health. |
| format | Article |
| id | doaj-art-12ea81af4d704497a27fba4400ef8e5c |
| institution | Kabale University |
| issn | 2090-9098 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | The Egyptian Journal of Internal Medicine |
| spelling | doaj-art-12ea81af4d704497a27fba4400ef8e5c2025-02-09T12:55:14ZengSpringerOpenThe Egyptian Journal of Internal Medicine2090-90982025-02-0137111310.1186/s43162-025-00401-4Tecovirimat in the management of poxviruses: a narrative review of available evidenceOlalekan John Okesanya0Jerico Bautista Ogaya1Ikponmwosa Jude Ogieuhi2Mohamed Mustaf Ahmed3Bonaventure Michael Ukoaka4Ojoisimi Franca Jamgbadi5Deborah Oluwaseun Shomuyiwa6Don Lucero-Prisno Eliseo7Blessing Olawunmi Amisu8Olakulehin Adebusuyi9William K. Chung10Emery Manirambona11Nimat Bola Idris12Janet Alexis A. De los Santos13Department of Public Health and Maritime Transport, University of ThessalyDepartment of Medical Technology, Institute of Health Sciences and Nursing, Far Eastern UniversitySiberian State Medical UniversityFaculty of Medicine and Health Sciences, SIMAD UniversityDepartment of Internal Medicine, Asokoro District HospitalFaculty of Pharmacy, University of BeninFaculty of Pharmacy, University of LagosDepartment of Global Health and Development, London School of Hygiene and Tropical MedicineFaculty of Pharmacy, University of IbadanDepartment of Medical Laboratory Services, State Hospital, Osun StateDepartment of Biology, Krieger School of Arts and Sciences, Johns Hopkins UniversityCollege of Medicine and Health Sciences, University of RwandaDepartment of Public Health, Al-Hikmah UniversityFaculty of Nursing, Visayas State UniversityAbstract Introduction Tecovirimat (TPOXX) is an effective antiviral medication recommended for treating smallpox and other Orthopoxvirus infections. With the rise in monkeypox (mpox) cases globally, there is an urgent need to explore therapeutic options to manage potential outbreaks. Methodology A literature search was conducted using keywords from Scopus and ClinicalTrials.gov. English studies from 2018 to 2024 were included. Results Ten studies assessing the effectiveness and safety of tecovirimat for poxvirus infections were evaluated, reporting diverse findings across different patient populations and study designs. Clinical trials have shown significant therapeutic potential. Various doses of tecovirimat were used in rabbit and mpox models. Early intervention slowed disease progression in vulnerable populations, such as people living with HIV (PLWHIV). Recovery times, virus eradication, and symptom relief varied among studies, but wider access and usage showed better clinical symptoms and tolerable side effects. Tecovirimat’s efficacy against circulating strains has been experimentally demonstrated. Conclusion Tecovirimat shows promise for treating poxvirus infections. Clinical trials are expected to provide more evidence-based findings to inform future therapeutic approaches and public health campaigns. Future research should explore tecovirimat’s potential in managing emerging poxvirus outbreaks, such as borealpox and mpox, to strengthen and promote public health.https://doi.org/10.1186/s43162-025-00401-4TecovirimatTPOXXPoxvirusesMonkeypoxSmallpoxMpox |
| spellingShingle | Olalekan John Okesanya Jerico Bautista Ogaya Ikponmwosa Jude Ogieuhi Mohamed Mustaf Ahmed Bonaventure Michael Ukoaka Ojoisimi Franca Jamgbadi Deborah Oluwaseun Shomuyiwa Don Lucero-Prisno Eliseo Blessing Olawunmi Amisu Olakulehin Adebusuyi William K. Chung Emery Manirambona Nimat Bola Idris Janet Alexis A. De los Santos Tecovirimat in the management of poxviruses: a narrative review of available evidence The Egyptian Journal of Internal Medicine Tecovirimat TPOXX Poxviruses Monkeypox Smallpox Mpox |
| title | Tecovirimat in the management of poxviruses: a narrative review of available evidence |
| title_full | Tecovirimat in the management of poxviruses: a narrative review of available evidence |
| title_fullStr | Tecovirimat in the management of poxviruses: a narrative review of available evidence |
| title_full_unstemmed | Tecovirimat in the management of poxviruses: a narrative review of available evidence |
| title_short | Tecovirimat in the management of poxviruses: a narrative review of available evidence |
| title_sort | tecovirimat in the management of poxviruses a narrative review of available evidence |
| topic | Tecovirimat TPOXX Poxviruses Monkeypox Smallpox Mpox |
| url | https://doi.org/10.1186/s43162-025-00401-4 |
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