Contemporary treatment of right ventricular failure
Right ventricular failure (RVF) is a clinical syndrome resulting from structural and functional changes in the right ventricle (RV), leading to inadequate blood flow to the pulmonary circulation and elevated systemic venous pressures. Factors modulating RV function include afterload, preload, contra...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-02-01
|
| Series: | JHLT Open |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2950133424001538 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1823864056457461760 |
|---|---|
| author | Bibhuti B. Das, MD Shashi Raj, MD, FAAP, FACC |
| author_facet | Bibhuti B. Das, MD Shashi Raj, MD, FAAP, FACC |
| author_sort | Bibhuti B. Das, MD |
| collection | DOAJ |
| description | Right ventricular failure (RVF) is a clinical syndrome resulting from structural and functional changes in the right ventricle (RV), leading to inadequate blood flow to the pulmonary circulation and elevated systemic venous pressures. Factors modulating RV function include afterload, preload, contractility, and interventricular dependency. The pathophysiology of RVF involves complex interactions, such as maladaptive hypertrophy, metabolic reprogramming, inflammation, fibrosis, apoptosis, and endothelial dysfunction. Therapeutic strategies are limited for RVF, as basic and clinical research has historically focused mainly on the left ventricle. Novel pharmacological interventions targeting metabolism, calcium homeostasis, oxidative stress, extracellular matrix remodeling, endothelial function, and inflammation are needed to address RVF effectively. This review explores the etiology, mechanisms, and pathophysiology of RVF, drugs directly targeting the RV myocardium, the intricate biological processes between RV and pulmonary vascular remodeling, surgical and device therapies, and future perspectives on managing RVF. |
| format | Article |
| id | doaj-art-138eefaadd7940c68e3ad99261c6ca90 |
| institution | Kabale University |
| issn | 2950-1334 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | JHLT Open |
| spelling | doaj-art-138eefaadd7940c68e3ad99261c6ca902025-02-09T05:02:01ZengElsevierJHLT Open2950-13342025-02-017100203Contemporary treatment of right ventricular failureBibhuti B. Das, MD0Shashi Raj, MD, FAAP, FACC1Department of Pediatrics, Division of Pediatric Cardiology, University of Mississippi Medical Center, Jackson, MississippiHeart Failure and Transplantation, Department of Pediatric Cardiology, Narayana Health, Bangalore, Karnataka, India; Corresponding author: Shashi Raj MD, FAAP, FACC, Department of Pediatric Cardiology, Narayana Health, Bangalore 560099, Karnataka, India.Right ventricular failure (RVF) is a clinical syndrome resulting from structural and functional changes in the right ventricle (RV), leading to inadequate blood flow to the pulmonary circulation and elevated systemic venous pressures. Factors modulating RV function include afterload, preload, contractility, and interventricular dependency. The pathophysiology of RVF involves complex interactions, such as maladaptive hypertrophy, metabolic reprogramming, inflammation, fibrosis, apoptosis, and endothelial dysfunction. Therapeutic strategies are limited for RVF, as basic and clinical research has historically focused mainly on the left ventricle. Novel pharmacological interventions targeting metabolism, calcium homeostasis, oxidative stress, extracellular matrix remodeling, endothelial function, and inflammation are needed to address RVF effectively. This review explores the etiology, mechanisms, and pathophysiology of RVF, drugs directly targeting the RV myocardium, the intricate biological processes between RV and pulmonary vascular remodeling, surgical and device therapies, and future perspectives on managing RVF.http://www.sciencedirect.com/science/article/pii/S2950133424001538right ventricular failureright heart failurepulmonary hypertensiontemporary RVADdurable RVAD |
| spellingShingle | Bibhuti B. Das, MD Shashi Raj, MD, FAAP, FACC Contemporary treatment of right ventricular failure JHLT Open right ventricular failure right heart failure pulmonary hypertension temporary RVAD durable RVAD |
| title | Contemporary treatment of right ventricular failure |
| title_full | Contemporary treatment of right ventricular failure |
| title_fullStr | Contemporary treatment of right ventricular failure |
| title_full_unstemmed | Contemporary treatment of right ventricular failure |
| title_short | Contemporary treatment of right ventricular failure |
| title_sort | contemporary treatment of right ventricular failure |
| topic | right ventricular failure right heart failure pulmonary hypertension temporary RVAD durable RVAD |
| url | http://www.sciencedirect.com/science/article/pii/S2950133424001538 |
| work_keys_str_mv | AT bibhutibdasmd contemporarytreatmentofrightventricularfailure AT shashirajmdfaapfacc contemporarytreatmentofrightventricularfailure |