Impact of type 2 diabetes mellitus on results in the animal naming test in patients with and without liver cirrhosis.
<h4>Introduction and objectives</h4>Diabetes mellitus is a common comorbidity in patients with cirrhosis and is associated with the development of hepatic encephalopathy (HE) and cognitive dysfunction. The simplified Animal Naming Test (S-ANT1) has been established for detecting minimal...
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| Format: | Article |
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Public Library of Science (PLoS)
2025-01-01
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| Online Access: | https://doi.org/10.1371/journal.pone.0316490 |
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| author | Eva Maria Schleicher Julia Tuchscher Matthias Weber Peter Robert Galle Marcus-Alexander Wörns Simon Johannes Gairing Christian Labenz |
| author_facet | Eva Maria Schleicher Julia Tuchscher Matthias Weber Peter Robert Galle Marcus-Alexander Wörns Simon Johannes Gairing Christian Labenz |
| author_sort | Eva Maria Schleicher |
| collection | DOAJ |
| description | <h4>Introduction and objectives</h4>Diabetes mellitus is a common comorbidity in patients with cirrhosis and is associated with the development of hepatic encephalopathy (HE) and cognitive dysfunction. The simplified Animal Naming Test (S-ANT1) has been established for detecting minimal HE (MHE). It is currently unknown whether S-ANT1 results are affected by diabetes mellitus in patients with and without cirrhosis.<h4>Materials and methods</h4>This study analyzed data from 268 patients with cirrhosis without signs of HE ≥ 1. MHE was defined using the psychometric hepatic encephalopathy score (PHES). All patients were also tested with S-ANT1. 14 patients with diabetes mellitus and diabetic foot syndrome but no cirrhosis, as well as 37 healthy controls, were also tested with S-ANT1 and served as controls.<h4>Results</h4>Type 2 diabetes mellitus was present in 79 (29.5%) patients with cirrhosis and MHE according to PHES was detected in 81 (30.2%) patients. In the total cohort, results in S-ANT1 did not differ between patients with and without diabetes mellitus (19 vs. 20 animals, p = 0.108). In multivariable logistic regression analysis, the only variables independently associated with performance in S-ANT1 were PHES-MHE, school education, sodium, and age, while diabetes mellitus was not. Patients with diabetic foot syndrome but no cirrhosis performed poorer in S-ANT1 compared to healthy controls, while patients with cirrhosis and MHE performed poorer than patients with diabetic foot syndrome.<h4>Conclusion</h4>S-ANT1 seems to be usable for screening for MHE in patients with cirrhosis and type 2 diabetes mellitus, while one might be more cautious when interpreting results in patients with diabetes-related complications. |
| format | Article |
| id | doaj-art-1410b1cdebf349d4a54e3cfe02a81cfd |
| institution | Kabale University |
| issn | 1932-6203 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Public Library of Science (PLoS) |
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| series | PLoS ONE |
| spelling | doaj-art-1410b1cdebf349d4a54e3cfe02a81cfd2025-02-12T05:30:57ZengPublic Library of Science (PLoS)PLoS ONE1932-62032025-01-01202e031649010.1371/journal.pone.0316490Impact of type 2 diabetes mellitus on results in the animal naming test in patients with and without liver cirrhosis.Eva Maria SchleicherJulia TuchscherMatthias WeberPeter Robert GalleMarcus-Alexander WörnsSimon Johannes GairingChristian Labenz<h4>Introduction and objectives</h4>Diabetes mellitus is a common comorbidity in patients with cirrhosis and is associated with the development of hepatic encephalopathy (HE) and cognitive dysfunction. The simplified Animal Naming Test (S-ANT1) has been established for detecting minimal HE (MHE). It is currently unknown whether S-ANT1 results are affected by diabetes mellitus in patients with and without cirrhosis.<h4>Materials and methods</h4>This study analyzed data from 268 patients with cirrhosis without signs of HE ≥ 1. MHE was defined using the psychometric hepatic encephalopathy score (PHES). All patients were also tested with S-ANT1. 14 patients with diabetes mellitus and diabetic foot syndrome but no cirrhosis, as well as 37 healthy controls, were also tested with S-ANT1 and served as controls.<h4>Results</h4>Type 2 diabetes mellitus was present in 79 (29.5%) patients with cirrhosis and MHE according to PHES was detected in 81 (30.2%) patients. In the total cohort, results in S-ANT1 did not differ between patients with and without diabetes mellitus (19 vs. 20 animals, p = 0.108). In multivariable logistic regression analysis, the only variables independently associated with performance in S-ANT1 were PHES-MHE, school education, sodium, and age, while diabetes mellitus was not. Patients with diabetic foot syndrome but no cirrhosis performed poorer in S-ANT1 compared to healthy controls, while patients with cirrhosis and MHE performed poorer than patients with diabetic foot syndrome.<h4>Conclusion</h4>S-ANT1 seems to be usable for screening for MHE in patients with cirrhosis and type 2 diabetes mellitus, while one might be more cautious when interpreting results in patients with diabetes-related complications.https://doi.org/10.1371/journal.pone.0316490 |
| spellingShingle | Eva Maria Schleicher Julia Tuchscher Matthias Weber Peter Robert Galle Marcus-Alexander Wörns Simon Johannes Gairing Christian Labenz Impact of type 2 diabetes mellitus on results in the animal naming test in patients with and without liver cirrhosis. PLoS ONE |
| title | Impact of type 2 diabetes mellitus on results in the animal naming test in patients with and without liver cirrhosis. |
| title_full | Impact of type 2 diabetes mellitus on results in the animal naming test in patients with and without liver cirrhosis. |
| title_fullStr | Impact of type 2 diabetes mellitus on results in the animal naming test in patients with and without liver cirrhosis. |
| title_full_unstemmed | Impact of type 2 diabetes mellitus on results in the animal naming test in patients with and without liver cirrhosis. |
| title_short | Impact of type 2 diabetes mellitus on results in the animal naming test in patients with and without liver cirrhosis. |
| title_sort | impact of type 2 diabetes mellitus on results in the animal naming test in patients with and without liver cirrhosis |
| url | https://doi.org/10.1371/journal.pone.0316490 |
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