Advancements in lung regeneration: from bench to bedside
Abstract Lung disorders rank among the leading causes of mortality worldwide, presenting a critical challenge in healthcare. The underlying limited regenerative capacity of the lung makes this an unmet clinical need, often necessitating lung transplantation for patients with severe lung disease. How...
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| Format: | Article |
| Language: | English |
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BMC
2025-02-01
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| Series: | Journal of Translational Medicine |
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| Online Access: | https://doi.org/10.1186/s12967-024-05954-6 |
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| author | Danial Khayatan Peyman Esmaeili Fard Barzegar Arooj Fatima Tayyaba Sattar Ambreen Zahid Syeda Aiman Batool Mehreen Jabbar Maryam Mureed Fatima Haider Aymun Javed Butt Sana Hanif Alexander Seifalian Hamid Tebyaniyan |
| author_facet | Danial Khayatan Peyman Esmaeili Fard Barzegar Arooj Fatima Tayyaba Sattar Ambreen Zahid Syeda Aiman Batool Mehreen Jabbar Maryam Mureed Fatima Haider Aymun Javed Butt Sana Hanif Alexander Seifalian Hamid Tebyaniyan |
| author_sort | Danial Khayatan |
| collection | DOAJ |
| description | Abstract Lung disorders rank among the leading causes of mortality worldwide, presenting a critical challenge in healthcare. The underlying limited regenerative capacity of the lung makes this an unmet clinical need, often necessitating lung transplantation for patients with severe lung disease. However, the lack of viable donor organs underscores the urgent need for alternative therapeutic strategies. Addressing this challenge requires a comprehensive understanding of the structure of lung tissue and the complexities inherent in its regeneration. In this review, we explore recent breakthroughs in lung regenerative medicine, highlighting innovative approaches aimed at tackling lung and tracheal diseases. From stem cell and cell-based therapies to the utilization of biological and synthetic materials, as well as the strategic deployment of growth factors, a diverse array of strategies is being explored to rejuvenate lung function. By critical analysis of in vitro, preclinical, and clinical studies, this review aims to provide a comprehensive overview of the emerging technology of lung regeneration research, shedding light on promising avenues for future therapeutic interventions. |
| format | Article |
| id | doaj-art-1493f06701d440288fac42966fa9d5b6 |
| institution | Kabale University |
| issn | 1479-5876 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Translational Medicine |
| spelling | doaj-art-1493f06701d440288fac42966fa9d5b62025-02-09T12:52:19ZengBMCJournal of Translational Medicine1479-58762025-02-0123112810.1186/s12967-024-05954-6Advancements in lung regeneration: from bench to bedsideDanial Khayatan0Peyman Esmaeili Fard Barzegar1Arooj Fatima2Tayyaba Sattar3Ambreen Zahid4Syeda Aiman Batool5Mehreen Jabbar6Maryam Mureed7Fatima Haider8Aymun Javed Butt9Sana Hanif10Alexander Seifalian11Hamid Tebyaniyan12Faculty of Pharmacy, Tehran Medical Sciences, Islamic Azad UniversityDepartment of Microbiology, Faculty of Veterinary Medicine, Lorestan UniversityUniversity Institute of Physical Therapy, University of LahoreUniversity Institute of Physical Therapy, University of LahoreInstitute of Physical Therapy, University of LahoreUniversity Institute of Physical Therapy, University of LahoreUniversity Institute of Physical Therapy, University of LahoreThe University of LahoreCentral Park Medical CollegeSocial Security HospitalFaculty of Pharmacy, The University of LahoreNanotechnology and Regenerative Medicine Commercialization Centre (NanoRegMed Ltd), LBIC, University of LondonFaculty of Pharmacy, The University of LahoreAbstract Lung disorders rank among the leading causes of mortality worldwide, presenting a critical challenge in healthcare. The underlying limited regenerative capacity of the lung makes this an unmet clinical need, often necessitating lung transplantation for patients with severe lung disease. However, the lack of viable donor organs underscores the urgent need for alternative therapeutic strategies. Addressing this challenge requires a comprehensive understanding of the structure of lung tissue and the complexities inherent in its regeneration. In this review, we explore recent breakthroughs in lung regenerative medicine, highlighting innovative approaches aimed at tackling lung and tracheal diseases. From stem cell and cell-based therapies to the utilization of biological and synthetic materials, as well as the strategic deployment of growth factors, a diverse array of strategies is being explored to rejuvenate lung function. By critical analysis of in vitro, preclinical, and clinical studies, this review aims to provide a comprehensive overview of the emerging technology of lung regeneration research, shedding light on promising avenues for future therapeutic interventions.https://doi.org/10.1186/s12967-024-05954-6Tissue engineeringBiomaterial3D scaffoldLung diseaseStem cellsGrowth factors |
| spellingShingle | Danial Khayatan Peyman Esmaeili Fard Barzegar Arooj Fatima Tayyaba Sattar Ambreen Zahid Syeda Aiman Batool Mehreen Jabbar Maryam Mureed Fatima Haider Aymun Javed Butt Sana Hanif Alexander Seifalian Hamid Tebyaniyan Advancements in lung regeneration: from bench to bedside Journal of Translational Medicine Tissue engineering Biomaterial 3D scaffold Lung disease Stem cells Growth factors |
| title | Advancements in lung regeneration: from bench to bedside |
| title_full | Advancements in lung regeneration: from bench to bedside |
| title_fullStr | Advancements in lung regeneration: from bench to bedside |
| title_full_unstemmed | Advancements in lung regeneration: from bench to bedside |
| title_short | Advancements in lung regeneration: from bench to bedside |
| title_sort | advancements in lung regeneration from bench to bedside |
| topic | Tissue engineering Biomaterial 3D scaffold Lung disease Stem cells Growth factors |
| url | https://doi.org/10.1186/s12967-024-05954-6 |
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