Eosinophilia predicts poor clinical outcomes in recent-onset arthritis: results from the ESPOIR cohort
Objectives To determine the prevalence of eosinophilia in patients with recent-onset arthritis suggestive of rheumatoid arthritis (RA) and to describe their features and outcomes.Methods We performed an ancillary study of data from a French prospective multicentre cohort study monitoring clinical, l...
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BMJ Publishing Group
2015-07-01
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| Series: | RMD Open |
| Online Access: | https://rmdopen.bmj.com/content/1/1/e000070.full |
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| author | Sandrine Jousse-Joulin Alain Saraux Thierry Marhadour Divi Cornec Gilles Chiocchia Valérie Devauchelle-Pensec Gabriel J Tobón Dewi Guellec Morgane Milin Olivier Vittecocq |
| author_facet | Sandrine Jousse-Joulin Alain Saraux Thierry Marhadour Divi Cornec Gilles Chiocchia Valérie Devauchelle-Pensec Gabriel J Tobón Dewi Guellec Morgane Milin Olivier Vittecocq |
| author_sort | Sandrine Jousse-Joulin |
| collection | DOAJ |
| description | Objectives To determine the prevalence of eosinophilia in patients with recent-onset arthritis suggestive of rheumatoid arthritis (RA) and to describe their features and outcomes.Methods We performed an ancillary study of data from a French prospective multicentre cohort study monitoring clinical, laboratory and radiographic data in patients with inflammatory arthritis of 6 weeks to 6 months duration. We determined the proportion of patients with eosinophilia, defined as a count >500/mm3, at baseline and after 3 years. Features of patients with and without baseline eosinophilia were compared.Results Baseline eosinophilia was evidenced in 26 of 804 (3.2%) patients; their mean eosinophil count was 637.7±107/mm3. Baseline eosinophilia was ascribed to atopic syndrome in 6 of 26 (23.1%) patients. After 3 years, patients with eosinophilia had higher Health Assessment Questionnaire scores (0.9 vs 0.5, p=0.004), higher patient visual analogue scale activity score and morning stiffness intensity (p=0.05), and were more often taking disease-modifying antirheumatic drugs (p=0.02). Baseline eosinophilia was not associated with presence of extra-articular manifestations.Conclusions Eosinophilia is rare in recent-onset arthritis suggestive of RA, and is usually directly related to the rheumatic disease. Our data suggest that patients with mild eosinophilia at diagnosis could respond worse to the treatment than those without. |
| format | Article |
| id | doaj-art-14f9e10541854949bb2f9e1cbfe134ae |
| institution | Kabale University |
| issn | 2056-5933 |
| language | English |
| publishDate | 2015-07-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | RMD Open |
| spelling | doaj-art-14f9e10541854949bb2f9e1cbfe134ae2025-02-07T01:40:11ZengBMJ Publishing GroupRMD Open2056-59332015-07-011110.1136/rmdopen-2015-000070Eosinophilia predicts poor clinical outcomes in recent-onset arthritis: results from the ESPOIR cohortSandrine Jousse-Joulin0Alain Saraux1Thierry Marhadour2Divi Cornec3Gilles Chiocchia4Valérie Devauchelle-Pensec5Gabriel J Tobón6Dewi Guellec7Morgane Milin8Olivier Vittecocq9LBAI, Univ Brest, Inserm, Brest, France, Brest, FranceDepartment of Rheumatology, Hopital Cavale Blanche, Brest, FranceRheumatology Department, Centre National de Référence des Maladies Auto-Immunes Rares (CERAINOM), CHU Brest, Brest, FranceU1227, LBAI, Univ Brest, Inserm, and CHU Brest, Brest, France, Brest, France3University Paris Diderot, Sorbonne Paris Cité, INFLAMEX, Laboratoire d’Excellence, Paris, FranceRheumatology, Brest University and La Cavale Blanche Hospital, Brest, FranceDepartment of Internal Medicine, Division of Rheumatology, Fundación Valle del Lili, ICESI University School of Medicine, Cali, ColumbiaRheumatology Department, Centre National de Référence des Maladies Auto-Immunes Rares (CERAINOM), CHU Brest, Brest, FranceDepartment of Rheumatology, CHU de la Cavale Blanche, Boulevard Tanguy Prigent, Brest, FranceRhumatologie & Inserm, U905 (IRIB) CIC 1404, CHU Hôpitaux de Rouen, Rouen, FranceObjectives To determine the prevalence of eosinophilia in patients with recent-onset arthritis suggestive of rheumatoid arthritis (RA) and to describe their features and outcomes.Methods We performed an ancillary study of data from a French prospective multicentre cohort study monitoring clinical, laboratory and radiographic data in patients with inflammatory arthritis of 6 weeks to 6 months duration. We determined the proportion of patients with eosinophilia, defined as a count >500/mm3, at baseline and after 3 years. Features of patients with and without baseline eosinophilia were compared.Results Baseline eosinophilia was evidenced in 26 of 804 (3.2%) patients; their mean eosinophil count was 637.7±107/mm3. Baseline eosinophilia was ascribed to atopic syndrome in 6 of 26 (23.1%) patients. After 3 years, patients with eosinophilia had higher Health Assessment Questionnaire scores (0.9 vs 0.5, p=0.004), higher patient visual analogue scale activity score and morning stiffness intensity (p=0.05), and were more often taking disease-modifying antirheumatic drugs (p=0.02). Baseline eosinophilia was not associated with presence of extra-articular manifestations.Conclusions Eosinophilia is rare in recent-onset arthritis suggestive of RA, and is usually directly related to the rheumatic disease. Our data suggest that patients with mild eosinophilia at diagnosis could respond worse to the treatment than those without.https://rmdopen.bmj.com/content/1/1/e000070.full |
| spellingShingle | Sandrine Jousse-Joulin Alain Saraux Thierry Marhadour Divi Cornec Gilles Chiocchia Valérie Devauchelle-Pensec Gabriel J Tobón Dewi Guellec Morgane Milin Olivier Vittecocq Eosinophilia predicts poor clinical outcomes in recent-onset arthritis: results from the ESPOIR cohort RMD Open |
| title | Eosinophilia predicts poor clinical outcomes in recent-onset arthritis: results from the ESPOIR cohort |
| title_full | Eosinophilia predicts poor clinical outcomes in recent-onset arthritis: results from the ESPOIR cohort |
| title_fullStr | Eosinophilia predicts poor clinical outcomes in recent-onset arthritis: results from the ESPOIR cohort |
| title_full_unstemmed | Eosinophilia predicts poor clinical outcomes in recent-onset arthritis: results from the ESPOIR cohort |
| title_short | Eosinophilia predicts poor clinical outcomes in recent-onset arthritis: results from the ESPOIR cohort |
| title_sort | eosinophilia predicts poor clinical outcomes in recent onset arthritis results from the espoir cohort |
| url | https://rmdopen.bmj.com/content/1/1/e000070.full |
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