Present-day pathophysiological concept of functional dyspepsia
The aim of review. To present modern data on the pathophysiological mechanisms causing functional dyspepsia (FD) syndrome.Key points. Nowadays FD is considered to be a complex multifactor process which cause and effect relationships are under continuous active study. Disorders of stomach motility (d...
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| Format: | Article |
| Language: | Russian |
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Gastro LLC
2015-09-01
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| Series: | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
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| Online Access: | https://www.gastro-j.ru/jour/article/view/1028 |
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| author | I. V. Mayev D. N. Andreev Yu. A. Kucheryavy D. T. Dicheva Yu. S. Subbotina |
| author_facet | I. V. Mayev D. N. Andreev Yu. A. Kucheryavy D. T. Dicheva Yu. S. Subbotina |
| author_sort | I. V. Mayev |
| collection | DOAJ |
| description | The aim of review. To present modern data on the pathophysiological mechanisms causing functional dyspepsia (FD) syndrome.Key points. Nowadays FD is considered to be a complex multifactor process which cause and effect relationships are under continuous active study. Disorders of stomach motility (delay of evacuation, disorders of relaxation accommodation) and sensitivity (visceral hypersensitivity to distention) are considered to be the basic pathophysiological mechanisms of FD. These changes develop approximately in 40% of FD patients. Besides that, alteration of duodenal sensitivity to hydrochloric acid and lipids can play significant role in genesis of FD.Conclusion. Mechanisms of FD are based on multiple heterogenous disorders of motor and sensitive functions of the stomach and duodenum. Due to major role of stomach motility disorders prokinetics are the priority drugs for treatment of FD. |
| format | Article |
| id | doaj-art-15923ee18b864f1d9c3177a3bd6b638c |
| institution | Kabale University |
| issn | 1382-4376 2658-6673 |
| language | Russian |
| publishDate | 2015-09-01 |
| publisher | Gastro LLC |
| record_format | Article |
| series | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
| spelling | doaj-art-15923ee18b864f1d9c3177a3bd6b638c2025-02-10T16:14:34ZrusGastro LLCРоссийский журнал гастроэнтерологии, гепатологии, колопроктологии1382-43762658-66732015-09-012541522633Present-day pathophysiological concept of functional dyspepsiaI. V. Mayev0D. N. Andreev1Yu. A. Kucheryavy2D. T. Dicheva3Yu. S. Subbotina4Yevdokimov Moscow State University of Medicine and Dentistry, Ministry of Healthcare of the Russian FederationYevdokimov Moscow State University of Medicine and Dentistry, Ministry of Healthcare of the Russian FederationYevdokimov Moscow State University of Medicine and Dentistry, Ministry of Healthcare of the Russian FederationYevdokimov Moscow State University of Medicine and Dentistry, Ministry of Healthcare of the Russian FederationYevdokimov Moscow State University of Medicine and Dentistry, Ministry of Healthcare of the Russian FederationThe aim of review. To present modern data on the pathophysiological mechanisms causing functional dyspepsia (FD) syndrome.Key points. Nowadays FD is considered to be a complex multifactor process which cause and effect relationships are under continuous active study. Disorders of stomach motility (delay of evacuation, disorders of relaxation accommodation) and sensitivity (visceral hypersensitivity to distention) are considered to be the basic pathophysiological mechanisms of FD. These changes develop approximately in 40% of FD patients. Besides that, alteration of duodenal sensitivity to hydrochloric acid and lipids can play significant role in genesis of FD.Conclusion. Mechanisms of FD are based on multiple heterogenous disorders of motor and sensitive functions of the stomach and duodenum. Due to major role of stomach motility disorders prokinetics are the priority drugs for treatment of FD.https://www.gastro-j.ru/jour/article/view/1028functional dyspepsiamotility disordersstomach evacuatory functionrelaxation accommodationvisceral hypersensitivityhydrochloric acidprokinetics |
| spellingShingle | I. V. Mayev D. N. Andreev Yu. A. Kucheryavy D. T. Dicheva Yu. S. Subbotina Present-day pathophysiological concept of functional dyspepsia Российский журнал гастроэнтерологии, гепатологии, колопроктологии functional dyspepsia motility disorders stomach evacuatory function relaxation accommodation visceral hypersensitivity hydrochloric acid prokinetics |
| title | Present-day pathophysiological concept of functional dyspepsia |
| title_full | Present-day pathophysiological concept of functional dyspepsia |
| title_fullStr | Present-day pathophysiological concept of functional dyspepsia |
| title_full_unstemmed | Present-day pathophysiological concept of functional dyspepsia |
| title_short | Present-day pathophysiological concept of functional dyspepsia |
| title_sort | present day pathophysiological concept of functional dyspepsia |
| topic | functional dyspepsia motility disorders stomach evacuatory function relaxation accommodation visceral hypersensitivity hydrochloric acid prokinetics |
| url | https://www.gastro-j.ru/jour/article/view/1028 |
| work_keys_str_mv | AT ivmayev presentdaypathophysiologicalconceptoffunctionaldyspepsia AT dnandreev presentdaypathophysiologicalconceptoffunctionaldyspepsia AT yuakucheryavy presentdaypathophysiologicalconceptoffunctionaldyspepsia AT dtdicheva presentdaypathophysiologicalconceptoffunctionaldyspepsia AT yussubbotina presentdaypathophysiologicalconceptoffunctionaldyspepsia |