Is the myonuclear domain ceiling hypothesis dead?
Muscle fibres are multinuclear cells, and the cytoplasmic territory where a single myonucleus controls transcriptional activity is called the myonuclear domain (MND). MND size shows flexibility during muscle hypertrophy. The MND ceiling hypothesis states that hypertrophy results in the expansion of...
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| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer – Medknow Publications
2023-07-01
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| Series: | Singapore Medical Journal |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.11622/smedj.2021103 |
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| _version_ | 1823861395474612224 |
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| author | Ferdos Aman Eman El Khatib Alanood AlNeaimi Ahmed Mohamed Alya Sultan Almulla Amna Zaidan Jana Alshafei Omar Habbal Salma Eldesouki Rizwan Qaisar |
| author_facet | Ferdos Aman Eman El Khatib Alanood AlNeaimi Ahmed Mohamed Alya Sultan Almulla Amna Zaidan Jana Alshafei Omar Habbal Salma Eldesouki Rizwan Qaisar |
| author_sort | Ferdos Aman |
| collection | DOAJ |
| description | Muscle fibres are multinuclear cells, and the cytoplasmic territory where a single myonucleus controls transcriptional activity is called the myonuclear domain (MND). MND size shows flexibility during muscle hypertrophy. The MND ceiling hypothesis states that hypertrophy results in the expansion of MND size to an upper limit or MND ceiling, beyond which additional myonuclei via activation of satellite cells are required to support further growth. However, the debate about the MND ceiling hypothesis is far from settled, and various studies show conflicting results about the existence or otherwise of MND ceiling in hypertrophy. The aim of this review is to summarise the literature about the MND ceiling in various settings of hypertrophy and discuss the possible factors contributing to a discrepancy in the literature. We conclude by describing the physiological and clinical significance of the MND ceiling limit in the muscle adaptation process in various physiological and pathological conditions. |
| format | Article |
| id | doaj-art-17f689ffdc5741839774b8f5f9f74eec |
| institution | Kabale University |
| issn | 0037-5675 2737-5935 |
| language | English |
| publishDate | 2023-07-01 |
| publisher | Wolters Kluwer – Medknow Publications |
| record_format | Article |
| series | Singapore Medical Journal |
| spelling | doaj-art-17f689ffdc5741839774b8f5f9f74eec2025-02-09T13:51:41ZengWolters Kluwer – Medknow PublicationsSingapore Medical Journal0037-56752737-59352023-07-0164741542210.11622/smedj.2021103Is the myonuclear domain ceiling hypothesis dead?Ferdos AmanEman El KhatibAlanood AlNeaimiAhmed MohamedAlya Sultan AlmullaAmna ZaidanJana AlshafeiOmar HabbalSalma EldesoukiRizwan QaisarMuscle fibres are multinuclear cells, and the cytoplasmic territory where a single myonucleus controls transcriptional activity is called the myonuclear domain (MND). MND size shows flexibility during muscle hypertrophy. The MND ceiling hypothesis states that hypertrophy results in the expansion of MND size to an upper limit or MND ceiling, beyond which additional myonuclei via activation of satellite cells are required to support further growth. However, the debate about the MND ceiling hypothesis is far from settled, and various studies show conflicting results about the existence or otherwise of MND ceiling in hypertrophy. The aim of this review is to summarise the literature about the MND ceiling in various settings of hypertrophy and discuss the possible factors contributing to a discrepancy in the literature. We conclude by describing the physiological and clinical significance of the MND ceiling limit in the muscle adaptation process in various physiological and pathological conditions.https://journals.lww.com/10.11622/smedj.2021103muscle hypertrophymyonuclear domainsatellite cellsskeletal muscle |
| spellingShingle | Ferdos Aman Eman El Khatib Alanood AlNeaimi Ahmed Mohamed Alya Sultan Almulla Amna Zaidan Jana Alshafei Omar Habbal Salma Eldesouki Rizwan Qaisar Is the myonuclear domain ceiling hypothesis dead? Singapore Medical Journal muscle hypertrophy myonuclear domain satellite cells skeletal muscle |
| title | Is the myonuclear domain ceiling hypothesis dead? |
| title_full | Is the myonuclear domain ceiling hypothesis dead? |
| title_fullStr | Is the myonuclear domain ceiling hypothesis dead? |
| title_full_unstemmed | Is the myonuclear domain ceiling hypothesis dead? |
| title_short | Is the myonuclear domain ceiling hypothesis dead? |
| title_sort | is the myonuclear domain ceiling hypothesis dead |
| topic | muscle hypertrophy myonuclear domain satellite cells skeletal muscle |
| url | https://journals.lww.com/10.11622/smedj.2021103 |
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