Bioactivity of plants used traditionally in the treatment and management of men’s sexual health
Background: In many African societies, men still rely on the long cultural history of utilising medicinal plants to treat and manage their sexual health. Aim: The study evaluated biological activities of 10 ethnobotanically selected medicinal plants. Setting: These plants are used traditionally to...
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| Format: | Article |
| Language: | English |
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AOSIS
2025-01-01
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| Series: | Journal of Medicinal Plants for Economic Development |
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| Online Access: | https://jomped.org/index.php/jomped/article/view/260 |
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| author | Tsumbedzo Nemandalali Monde A. Nyila Thilivhali E. Tshikalange |
| author_facet | Tsumbedzo Nemandalali Monde A. Nyila Thilivhali E. Tshikalange |
| author_sort | Tsumbedzo Nemandalali |
| collection | DOAJ |
| description | Background: In many African societies, men still rely on the long cultural history of utilising medicinal plants to treat and manage their sexual health.
Aim: The study evaluated biological activities of 10 ethnobotanically selected medicinal plants.
Setting: These plants are used traditionally to treat and manage men’s sexual health in villages under the Thengwe Tribal Authority, Limpopo province.
Methods: Acetone extracts were investigated for their antioxidant activity, anti-inflammatory activity against 15-lipoxygenase, inhibition of nitric oxide production on RAW 264.7 macrophages and antimicrobial activity against Neisseria gonorrhoeae and Candida albicans. Phytochemical analysis was performed by determination of total flavonoid and total phenolic content.
Results: All the extracts investigated showed moderate to high content of flavonoids and total phenolic content. Cytotoxicity of the extracts was assessed using the XTT reduction assay against Vero monkey kidney cells. Diospyros mespiliformis extract was less toxic and showed significant antioxidant (IC50 = 8.34 µg/mL), anti-inflammatory (IC50 = 63 µg/mL) and antigonococcal (MIC = 0.39 mg/mL) activities. Extracts from Garcinia livingstonei and Rhoicissus tridentata also exhibited promising bioactivity. While these three extracts seem to inhibit the production of nitric oxide, the rest of the extracts seem to promote its production.
Conclusion: The findings of the study revealed that the selected plants possess biological activities directly and indirectly associated with men’s sexual health.
Contribution: The investigated plants have potential therapeutic effects and can be used as leads in the development of new pharmaceuticals to manage men’s sexual disorders. |
| format | Article |
| id | doaj-art-19ef5ee7bf9f47d8aeebf925c184d894 |
| institution | Kabale University |
| issn | 2519-559X 2616-4809 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | AOSIS |
| record_format | Article |
| series | Journal of Medicinal Plants for Economic Development |
| spelling | doaj-art-19ef5ee7bf9f47d8aeebf925c184d8942025-02-11T13:24:35ZengAOSISJournal of Medicinal Plants for Economic Development2519-559X2616-48092025-01-0191e1e710.4102/jomped.v9i1.260121Bioactivity of plants used traditionally in the treatment and management of men’s sexual healthTsumbedzo Nemandalali0Monde A. Nyila1Thilivhali E. Tshikalange2Department of Life and Consumer Sciences, College of Agriculture and Environmental Sciences, University of South Africa, FloridaDepartment of Life and Consumer Sciences, College of Agriculture and Environmental Sciences, University of South Africa, FloridaDepartment of Plant and Soil Sciences, Faculty of Natural and Agricultural Sciences, University of Pretoria, PretoriaBackground: In many African societies, men still rely on the long cultural history of utilising medicinal plants to treat and manage their sexual health. Aim: The study evaluated biological activities of 10 ethnobotanically selected medicinal plants. Setting: These plants are used traditionally to treat and manage men’s sexual health in villages under the Thengwe Tribal Authority, Limpopo province. Methods: Acetone extracts were investigated for their antioxidant activity, anti-inflammatory activity against 15-lipoxygenase, inhibition of nitric oxide production on RAW 264.7 macrophages and antimicrobial activity against Neisseria gonorrhoeae and Candida albicans. Phytochemical analysis was performed by determination of total flavonoid and total phenolic content. Results: All the extracts investigated showed moderate to high content of flavonoids and total phenolic content. Cytotoxicity of the extracts was assessed using the XTT reduction assay against Vero monkey kidney cells. Diospyros mespiliformis extract was less toxic and showed significant antioxidant (IC50 = 8.34 µg/mL), anti-inflammatory (IC50 = 63 µg/mL) and antigonococcal (MIC = 0.39 mg/mL) activities. Extracts from Garcinia livingstonei and Rhoicissus tridentata also exhibited promising bioactivity. While these three extracts seem to inhibit the production of nitric oxide, the rest of the extracts seem to promote its production. Conclusion: The findings of the study revealed that the selected plants possess biological activities directly and indirectly associated with men’s sexual health. Contribution: The investigated plants have potential therapeutic effects and can be used as leads in the development of new pharmaceuticals to manage men’s sexual disorders.https://jomped.org/index.php/jomped/article/view/260medicinal plantsnitric oxideneisseria gonorrhoeacandida albicanssexual health. |
| spellingShingle | Tsumbedzo Nemandalali Monde A. Nyila Thilivhali E. Tshikalange Bioactivity of plants used traditionally in the treatment and management of men’s sexual health Journal of Medicinal Plants for Economic Development medicinal plants nitric oxide neisseria gonorrhoea candida albicans sexual health. |
| title | Bioactivity of plants used traditionally in the treatment and management of men’s sexual health |
| title_full | Bioactivity of plants used traditionally in the treatment and management of men’s sexual health |
| title_fullStr | Bioactivity of plants used traditionally in the treatment and management of men’s sexual health |
| title_full_unstemmed | Bioactivity of plants used traditionally in the treatment and management of men’s sexual health |
| title_short | Bioactivity of plants used traditionally in the treatment and management of men’s sexual health |
| title_sort | bioactivity of plants used traditionally in the treatment and management of men s sexual health |
| topic | medicinal plants nitric oxide neisseria gonorrhoea candida albicans sexual health. |
| url | https://jomped.org/index.php/jomped/article/view/260 |
| work_keys_str_mv | AT tsumbedzonemandalali bioactivityofplantsusedtraditionallyinthetreatmentandmanagementofmenssexualhealth AT mondeanyila bioactivityofplantsusedtraditionallyinthetreatmentandmanagementofmenssexualhealth AT thilivhalietshikalange bioactivityofplantsusedtraditionallyinthetreatmentandmanagementofmenssexualhealth |