CD109, a master regulator of inflammatory responses
Inflammation is a complex response to harmful stimuli, crucial for immunity, and linked to chronic diseases and cancer, with TGF-β and NF-κB pathways as key regulators. CD109 is a glycosylphosphatidylinositol (GPI)-anchored protein, that our group has originally identified as a TGF-β co-receptor and...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1505008/full |
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| author | Adel Batal Adel Batal Setareh Garousi Setareh Garousi Kenneth W. Finnson Kenneth W. Finnson Anie Philip Anie Philip |
| author_facet | Adel Batal Adel Batal Setareh Garousi Setareh Garousi Kenneth W. Finnson Kenneth W. Finnson Anie Philip Anie Philip |
| author_sort | Adel Batal |
| collection | DOAJ |
| description | Inflammation is a complex response to harmful stimuli, crucial for immunity, and linked to chronic diseases and cancer, with TGF-β and NF-κB pathways as key regulators. CD109 is a glycosylphosphatidylinositol (GPI)-anchored protein, that our group has originally identified as a TGF-β co-receptor and inhibitor of TGF-β signaling. CD109 modulates TGF-β and NF-κB pathways, to influence immune responses and inflammation. CD109’s multifaceted role in inflammation spans various tissue types, including the skin, lung, bone and bone-related tissues, and various types of cancers. CD109 exerts its effects by modulating processes such as cytokine secretion, immune cell recruitment, macrophage polarization, T helper cell function and cancer cell phenotype and function. Here, we review CD109’s regulatory functions in inflammatory responses in these various tissues and cell types. Exploration of CD109’s mechanisms of action will enhance our understanding of its contributions to disease pathology and its potential for therapeutic applications. |
| format | Article |
| id | doaj-art-19fdda76ad3941d9b4a920fb6ea8a019 |
| institution | Kabale University |
| issn | 1664-3224 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-19fdda76ad3941d9b4a920fb6ea8a0192025-02-07T06:49:49ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-02-011510.3389/fimmu.2024.15050081505008CD109, a master regulator of inflammatory responsesAdel Batal0Adel Batal1Setareh Garousi2Setareh Garousi3Kenneth W. Finnson4Kenneth W. Finnson5Anie Philip6Anie Philip7Division of Plastic Surgery, Department of Surgery, McGill University, Montreal, QC, CanadaSurgical and Interventional Sciences Program, The Research Institute of the McGill University Health Centre, Montreal, QC, CanadaDivision of Plastic Surgery, Department of Surgery, McGill University, Montreal, QC, CanadaSurgical and Interventional Sciences Program, The Research Institute of the McGill University Health Centre, Montreal, QC, CanadaDivision of Plastic Surgery, Department of Surgery, McGill University, Montreal, QC, CanadaSurgical and Interventional Sciences Program, The Research Institute of the McGill University Health Centre, Montreal, QC, CanadaDivision of Plastic Surgery, Department of Surgery, McGill University, Montreal, QC, CanadaSurgical and Interventional Sciences Program, The Research Institute of the McGill University Health Centre, Montreal, QC, CanadaInflammation is a complex response to harmful stimuli, crucial for immunity, and linked to chronic diseases and cancer, with TGF-β and NF-κB pathways as key regulators. CD109 is a glycosylphosphatidylinositol (GPI)-anchored protein, that our group has originally identified as a TGF-β co-receptor and inhibitor of TGF-β signaling. CD109 modulates TGF-β and NF-κB pathways, to influence immune responses and inflammation. CD109’s multifaceted role in inflammation spans various tissue types, including the skin, lung, bone and bone-related tissues, and various types of cancers. CD109 exerts its effects by modulating processes such as cytokine secretion, immune cell recruitment, macrophage polarization, T helper cell function and cancer cell phenotype and function. Here, we review CD109’s regulatory functions in inflammatory responses in these various tissues and cell types. Exploration of CD109’s mechanisms of action will enhance our understanding of its contributions to disease pathology and its potential for therapeutic applications.https://www.frontiersin.org/articles/10.3389/fimmu.2024.1505008/fullCD109inflammatory responseTGF-β signalingNF-κB signalingpathway crosstalk |
| spellingShingle | Adel Batal Adel Batal Setareh Garousi Setareh Garousi Kenneth W. Finnson Kenneth W. Finnson Anie Philip Anie Philip CD109, a master regulator of inflammatory responses Frontiers in Immunology CD109 inflammatory response TGF-β signaling NF-κB signaling pathway crosstalk |
| title | CD109, a master regulator of inflammatory responses |
| title_full | CD109, a master regulator of inflammatory responses |
| title_fullStr | CD109, a master regulator of inflammatory responses |
| title_full_unstemmed | CD109, a master regulator of inflammatory responses |
| title_short | CD109, a master regulator of inflammatory responses |
| title_sort | cd109 a master regulator of inflammatory responses |
| topic | CD109 inflammatory response TGF-β signaling NF-κB signaling pathway crosstalk |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1505008/full |
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