Roxadustat improves diabetic myocardial injury by upregulating HIF-1α/UCP2 against oxidative stress

Roxadustat improves diabetic myocardial injury by upregulating HIF-1α/UCP2 against oxidative stress

Abstract Background Diabetes mellitus (DM), characterized by hyperglycemia, is intricately linked with cardiovascular complications. Hyperglycemia induces oxidative stress, compromising mitochondria energy metabolism disturbances, leading to cardiomyocyte hypoxia and dysregulation of hypoxia-inducib...

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Bibliographic Details
Main Authors: Tingting Fang, Congcong Ma, Bingyun Yang, Meiyu Zhao, Luning Sun, Ningning Zheng
Format: Article
Language:English
Published: BMC 2025-02-01
Series:Cardiovascular Diabetology
Subjects:
Roxadustat
Diabetes mellitus
Diabetic myocardial injury
Uncoupling protein 2
Hypoxia-inducible factor -1α
Oxidative stress
Online Access:https://doi.org/10.1186/s12933-025-02601-2
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