Near-infrared light triggered in situ release of CO for enhanced therapy of glioblastoma
Abstract Background Photodynamic therapy (PDT) features high biocompatibility and high spatiotemporal selectivity, showing a great potential in glioblastoma (GBM) treatment. However, its application was restricted by the poor therapeutic efficacy and side effect. Results In this study, a therapeutic...
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BMC
2023-02-01
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| Series: | Journal of Nanobiotechnology |
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| Online Access: | https://doi.org/10.1186/s12951-023-01802-9 |
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| author | Juan Ge Miaomiao Zuo Qirong Wang Zhen Li |
| author_facet | Juan Ge Miaomiao Zuo Qirong Wang Zhen Li |
| author_sort | Juan Ge |
| collection | DOAJ |
| description | Abstract Background Photodynamic therapy (PDT) features high biocompatibility and high spatiotemporal selectivity, showing a great potential in glioblastoma (GBM) treatment. However, its application was restricted by the poor therapeutic efficacy and side effect. Results In this study, a therapeutic nanoplatform (UCNPs@Ce6/3HBQ@CM) with combination of PDT and CO therapy was constructed, in which a photoCORM and a photosensitizer were loaded onto the surface of upconversion nanoparticles (UCNPs) functioning as photon transducer. Benefitting from NIR excitation and multicolor emission of UCNPs, the penetration depth of excitation light is enhanced and meanwhile simultaneous generation of CO and ROS in tumor site can be achieved. The as-prepared nanocomposite possessed an elevated therapeutic efficiency with the assistance of CO through influencing mitochondrial respiration and depleting ATP, accompanying with the reduced inflammatory responses. By wrapping a homologous cell membrane, the nanocomposite can target GBM and accumulate in the tumor site, affording a powerful tool for precise and efficient treatment of GBM. Conclusion This therapeutic nanoplatform UCNPs@Ce6/3HBQ@CM, which combines PDT and CO therapy enables precise and efficient treatment of refractory glioblastoma. |
| format | Article |
| id | doaj-art-1b2a2c2342d4462ca42fbe6088a14166 |
| institution | Kabale University |
| issn | 1477-3155 |
| language | English |
| publishDate | 2023-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Nanobiotechnology |
| spelling | doaj-art-1b2a2c2342d4462ca42fbe6088a141662025-02-09T12:52:54ZengBMCJournal of Nanobiotechnology1477-31552023-02-0121111510.1186/s12951-023-01802-9Near-infrared light triggered in situ release of CO for enhanced therapy of glioblastomaJuan Ge0Miaomiao Zuo1Qirong Wang2Zhen Li3College of Health Science and Engineering, College of Chemistry and Chemical Engineering, Hubei UniversityCollege of Health Science and Engineering, College of Chemistry and Chemical Engineering, Hubei UniversityCollege of Health Science and Engineering, College of Chemistry and Chemical Engineering, Hubei UniversityCollege of Health Science and Engineering, College of Chemistry and Chemical Engineering, Hubei UniversityAbstract Background Photodynamic therapy (PDT) features high biocompatibility and high spatiotemporal selectivity, showing a great potential in glioblastoma (GBM) treatment. However, its application was restricted by the poor therapeutic efficacy and side effect. Results In this study, a therapeutic nanoplatform (UCNPs@Ce6/3HBQ@CM) with combination of PDT and CO therapy was constructed, in which a photoCORM and a photosensitizer were loaded onto the surface of upconversion nanoparticles (UCNPs) functioning as photon transducer. Benefitting from NIR excitation and multicolor emission of UCNPs, the penetration depth of excitation light is enhanced and meanwhile simultaneous generation of CO and ROS in tumor site can be achieved. The as-prepared nanocomposite possessed an elevated therapeutic efficiency with the assistance of CO through influencing mitochondrial respiration and depleting ATP, accompanying with the reduced inflammatory responses. By wrapping a homologous cell membrane, the nanocomposite can target GBM and accumulate in the tumor site, affording a powerful tool for precise and efficient treatment of GBM. Conclusion This therapeutic nanoplatform UCNPs@Ce6/3HBQ@CM, which combines PDT and CO therapy enables precise and efficient treatment of refractory glioblastoma.https://doi.org/10.1186/s12951-023-01802-9Carbon monoxidePhotodynamic therapyAnti-inflammatoryUpconversion nanoparticlesGlioblastoma |
| spellingShingle | Juan Ge Miaomiao Zuo Qirong Wang Zhen Li Near-infrared light triggered in situ release of CO for enhanced therapy of glioblastoma Journal of Nanobiotechnology Carbon monoxide Photodynamic therapy Anti-inflammatory Upconversion nanoparticles Glioblastoma |
| title | Near-infrared light triggered in situ release of CO for enhanced therapy of glioblastoma |
| title_full | Near-infrared light triggered in situ release of CO for enhanced therapy of glioblastoma |
| title_fullStr | Near-infrared light triggered in situ release of CO for enhanced therapy of glioblastoma |
| title_full_unstemmed | Near-infrared light triggered in situ release of CO for enhanced therapy of glioblastoma |
| title_short | Near-infrared light triggered in situ release of CO for enhanced therapy of glioblastoma |
| title_sort | near infrared light triggered in situ release of co for enhanced therapy of glioblastoma |
| topic | Carbon monoxide Photodynamic therapy Anti-inflammatory Upconversion nanoparticles Glioblastoma |
| url | https://doi.org/10.1186/s12951-023-01802-9 |
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