Manipulating the cGAS-STING Axis: advancing innovative strategies for osteosarcoma therapeutics

Manipulating the cGAS-STING Axis: advancing innovative strategies for osteosarcoma therapeutics

This paper explored the novel approach of targeting the cyclic guanosine monophosphate (GMP)-adenosine monophosphate (AMP) synthase-stimulator of interferon genes (cGAS-STING) pathway for the treatment of osteosarcoma (OS). Osteosarcoma is a common malignancy in adolescents. Most patients die from l...

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Bibliographic Details
Main Authors: BingBing Li, Cheng Zhang, XiaoJuan Xu, QiQin Shen, ShuNan Luo, JunFeng Hu
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-02-01
Series:Frontiers in Immunology
Subjects:
osteosarcoma
cGAS-STING
treatment target
drug
tumor immunity
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1539396/full
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