Small open reading frames (sORFs): Driving big improvements in plant development and quality
Small open reading frames (sORFs) are defined as short nucleotide sequences, typically no longer than 300 base pairs, which have the potential to encode small peptides. With the advent of sophisticated technologies such as bioinformatics, ribosome profiling, and mass spectrometry, the investigation...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-03-01
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| Series: | Plant Stress |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667064X25000260 |
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| author | Kui Dong Chaofan Shan Dongyu Wen Zifan Cui Jun Cao |
| author_facet | Kui Dong Chaofan Shan Dongyu Wen Zifan Cui Jun Cao |
| author_sort | Kui Dong |
| collection | DOAJ |
| description | Small open reading frames (sORFs) are defined as short nucleotide sequences, typically no longer than 300 base pairs, which have the potential to encode small peptides. With the advent of sophisticated technologies such as bioinformatics, ribosome profiling, and mass spectrometry, the investigation of sORFs has experienced a transformative shift and significant expansion. This review provides a comprehensive analysis of the identification, categorization, functional mechanisms, and diverse roles of sORFs in plant development. In the plant, sORFs are pivotal components that enhance responses to both biotic and abiotic stresses by encoding small peptides that are either intricately involved in complex hormone regulation and signaling networks, or precisely regulate the expression of downstream resistance genes. The impact of sORFs extends well beyond stress resistance and they are also implicated in the developmental and physiological functions of plants. sORFs play a crucial role in determing the overall morphological architecture of plants, governing morphological changes throughout the plant life cycle, and are instrumental in regulating metabolite accumulation, which influences plant quality. The synergistic application of sORFs with gene editing technologies holds great promise, not only for devising novel strategies to improve plant quality, resulting in crops that are more resistant, nutrient-rich, and productive, but also for establishing innovative molecular breeding pathways. In summary, understanding and harnessing the potential of sORFs is a cutting-edge area of research that is poised to revolutionize the future of plant biology and agriculture, and ongoing exploration of their functions and mechanisms is anticipated to yield groundbreaking discoveries and practical applications in the future. |
| format | Article |
| id | doaj-art-1e07c75ac6244b36bf8ebb51588f425a |
| institution | Kabale University |
| issn | 2667-064X |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Plant Stress |
| spelling | doaj-art-1e07c75ac6244b36bf8ebb51588f425a2025-02-12T05:33:03ZengElsevierPlant Stress2667-064X2025-03-0115100761Small open reading frames (sORFs): Driving big improvements in plant development and qualityKui Dong0Chaofan Shan1Dongyu Wen2Zifan Cui3Jun Cao4School of Life Sciences, Jiangsu University, Zhenjiang 212013, Jiangsu, ChinaSchool of Life Sciences, Jiangsu University, Zhenjiang 212013, Jiangsu, ChinaSchool of Life Sciences, Jiangsu University, Zhenjiang 212013, Jiangsu, ChinaSchool of Life Sciences, Jiangsu University, Zhenjiang 212013, Jiangsu, ChinaCorresponding author.; School of Life Sciences, Jiangsu University, Zhenjiang 212013, Jiangsu, ChinaSmall open reading frames (sORFs) are defined as short nucleotide sequences, typically no longer than 300 base pairs, which have the potential to encode small peptides. With the advent of sophisticated technologies such as bioinformatics, ribosome profiling, and mass spectrometry, the investigation of sORFs has experienced a transformative shift and significant expansion. This review provides a comprehensive analysis of the identification, categorization, functional mechanisms, and diverse roles of sORFs in plant development. In the plant, sORFs are pivotal components that enhance responses to both biotic and abiotic stresses by encoding small peptides that are either intricately involved in complex hormone regulation and signaling networks, or precisely regulate the expression of downstream resistance genes. The impact of sORFs extends well beyond stress resistance and they are also implicated in the developmental and physiological functions of plants. sORFs play a crucial role in determing the overall morphological architecture of plants, governing morphological changes throughout the plant life cycle, and are instrumental in regulating metabolite accumulation, which influences plant quality. The synergistic application of sORFs with gene editing technologies holds great promise, not only for devising novel strategies to improve plant quality, resulting in crops that are more resistant, nutrient-rich, and productive, but also for establishing innovative molecular breeding pathways. In summary, understanding and harnessing the potential of sORFs is a cutting-edge area of research that is poised to revolutionize the future of plant biology and agriculture, and ongoing exploration of their functions and mechanisms is anticipated to yield groundbreaking discoveries and practical applications in the future.http://www.sciencedirect.com/science/article/pii/S2667064X25000260Biotic and abiotic stress resistanceNutrient uptake efficiencyPlant quality improvementRoot developmentSmall peptidessORFs |
| spellingShingle | Kui Dong Chaofan Shan Dongyu Wen Zifan Cui Jun Cao Small open reading frames (sORFs): Driving big improvements in plant development and quality Plant Stress Biotic and abiotic stress resistance Nutrient uptake efficiency Plant quality improvement Root development Small peptides sORFs |
| title | Small open reading frames (sORFs): Driving big improvements in plant development and quality |
| title_full | Small open reading frames (sORFs): Driving big improvements in plant development and quality |
| title_fullStr | Small open reading frames (sORFs): Driving big improvements in plant development and quality |
| title_full_unstemmed | Small open reading frames (sORFs): Driving big improvements in plant development and quality |
| title_short | Small open reading frames (sORFs): Driving big improvements in plant development and quality |
| title_sort | small open reading frames sorfs driving big improvements in plant development and quality |
| topic | Biotic and abiotic stress resistance Nutrient uptake efficiency Plant quality improvement Root development Small peptides sORFs |
| url | http://www.sciencedirect.com/science/article/pii/S2667064X25000260 |
| work_keys_str_mv | AT kuidong smallopenreadingframessorfsdrivingbigimprovementsinplantdevelopmentandquality AT chaofanshan smallopenreadingframessorfsdrivingbigimprovementsinplantdevelopmentandquality AT dongyuwen smallopenreadingframessorfsdrivingbigimprovementsinplantdevelopmentandquality AT zifancui smallopenreadingframessorfsdrivingbigimprovementsinplantdevelopmentandquality AT juncao smallopenreadingframessorfsdrivingbigimprovementsinplantdevelopmentandquality |