An unmet need: Pancreatic beta cell replacement
Diabetes mellitus (DM) is a growing public health concern in South Africa (SA) and poses a substantial economic burden on healthcare globally. A century has passed since the discovery of insulin, and despite advances in diabetes management, exogenous insulin remains a primary treatment for type...
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| Format: | Article |
| Language: | English |
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South African Medical Association
2024-04-01
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| Series: | South African Medical Journal |
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| Online Access: | https://samajournals.co.za/index.php/samj/article/view/1249 |
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| author | F Mohamed C Adams B Mansfield |
| author_facet | F Mohamed C Adams B Mansfield |
| author_sort | F Mohamed |
| collection | DOAJ |
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Diabetes mellitus (DM) is a growing public health concern in South Africa (SA) and poses a substantial economic burden on healthcare globally. A century has passed since the discovery of insulin, and despite advances in diabetes management, exogenous insulin remains a primary treatment for type 1 DM, posing challenges of hyperglycaemia and hypoglycaemia. Pancreas transplantation should be considered a treatment for insulin-deficient DM, offering sustained euglycaemia and preventing complications associated with the disease. However, there has been a global decrease in the number of transplants performed. In SA, only a few pancreas transplants have been performed, primarily because of surgical risks and the need for immunosuppression. Islet transplantation is an alternative but faces limitations due to donor scarcity and immunosuppression requirements. This review explores recent progress in pancreas and islet transplants for DM, with the aim of providing insights into expanding treatment options for people with insulin-deficient DM.
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| format | Article |
| id | doaj-art-1e5ad656eff24700ab892c9e1f12e5d5 |
| institution | Kabale University |
| issn | 0256-9574 2078-5135 |
| language | English |
| publishDate | 2024-04-01 |
| publisher | South African Medical Association |
| record_format | Article |
| series | South African Medical Journal |
| spelling | doaj-art-1e5ad656eff24700ab892c9e1f12e5d52025-02-10T12:26:15ZengSouth African Medical AssociationSouth African Medical Journal0256-95742078-51352024-04-011143b10.7196/SAMJ.2024.v114i3b.1249An unmet need: Pancreatic beta cell replacementF Mohamed0https://orcid.org/0000-0001-5602-3621C Adams1https://orcid.org/0000-0003-3977-4620B Mansfield2https://orcid.org/0000-0002-8042-7041Division of Endocrinology and Metabolism, Department of Internal Medicine, Faculty of Health Sciences, University of the Witwatersrand and Charlotte Maxeke Johannesburg Academic Hospital, Johannesburg, South AfricaDivision of Endocrinology and Metabolism, Department of Internal Medicine, Faculty of Health Sciences, University of the Witwatersrand and Charlotte Maxeke Johannesburg Academic Hospital, Johannesburg, South AfricaDivision of Endocrinology and Metabolism, Department of Internal Medicine, Faculty of Health Sciences, University of the Witwatersrand and Charlotte Maxeke Johannesburg Academic Hospital, Johannesburg, South Africa Diabetes mellitus (DM) is a growing public health concern in South Africa (SA) and poses a substantial economic burden on healthcare globally. A century has passed since the discovery of insulin, and despite advances in diabetes management, exogenous insulin remains a primary treatment for type 1 DM, posing challenges of hyperglycaemia and hypoglycaemia. Pancreas transplantation should be considered a treatment for insulin-deficient DM, offering sustained euglycaemia and preventing complications associated with the disease. However, there has been a global decrease in the number of transplants performed. In SA, only a few pancreas transplants have been performed, primarily because of surgical risks and the need for immunosuppression. Islet transplantation is an alternative but faces limitations due to donor scarcity and immunosuppression requirements. This review explores recent progress in pancreas and islet transplants for DM, with the aim of providing insights into expanding treatment options for people with insulin-deficient DM. https://samajournals.co.za/index.php/samj/article/view/1249DiabetesPancreatic transplantIslet transplant |
| spellingShingle | F Mohamed C Adams B Mansfield An unmet need: Pancreatic beta cell replacement South African Medical Journal Diabetes Pancreatic transplant Islet transplant |
| title | An unmet need: Pancreatic beta cell replacement |
| title_full | An unmet need: Pancreatic beta cell replacement |
| title_fullStr | An unmet need: Pancreatic beta cell replacement |
| title_full_unstemmed | An unmet need: Pancreatic beta cell replacement |
| title_short | An unmet need: Pancreatic beta cell replacement |
| title_sort | unmet need pancreatic beta cell replacement |
| topic | Diabetes Pancreatic transplant Islet transplant |
| url | https://samajournals.co.za/index.php/samj/article/view/1249 |
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