Pathological features and immunohistochemical characteristics of clear cell (glycogen-rich) urothelial carcinoma: a case report and systematic review of the literature
Abstract Clear cell (glycogen-rich) urothelial carcinoma is an exceedingly rare variant of invasive urothelial carcinoma, distinguished by the presence of abundant cytoplasmic glycogen, which imparts a clear appearance to the tumor cells under histological examination. In this case report, the diagn...
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Springer
2025-02-01
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| Series: | Discover Oncology |
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| Online Access: | https://doi.org/10.1007/s12672-025-01813-y |
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| author | Weiming Wang Baogang Zhang Zhangli Wu Chuanling Hou Mengyao Li Tianyi Zhang |
| author_facet | Weiming Wang Baogang Zhang Zhangli Wu Chuanling Hou Mengyao Li Tianyi Zhang |
| author_sort | Weiming Wang |
| collection | DOAJ |
| description | Abstract Clear cell (glycogen-rich) urothelial carcinoma is an exceedingly rare variant of invasive urothelial carcinoma, distinguished by the presence of abundant cytoplasmic glycogen, which imparts a clear appearance to the tumor cells under histological examination. In this case report, the diagnosis was established through histopathological evaluation with hematoxylin and eosin (HE) staining, immunohistochemical analysis, and the identification of significant cytoplasmic glycogen accumulation. The patient, an 89-year-old male, was admitted on July 24, 2024, presenting with painless gross hematuria persisting for one week. Abdominal ultrasound and CT urography revealed a soft tissue mass on the right side of the bladder wall, measuring 30 × 30 mm, with a broad base connected to the bladder wall. The mass exhibited significant enhancement on contrast-enhanced scans, raising suspicion for malignancy. Microscopic examination revealed two distinct tumor cell morphologies: the conventional urothelial carcinoma pattern and a clear nest-like morphology, with the latter comprising over 70% of the tumor. Immunohistochemical staining for GATA-3, CK7, PAS, PAS-D, CAIX, PAX8, and RCC confirmed the diagnosis of clear cell (glycogen-rich) urothelial carcinoma. This rare variant of invasive urothelial carcinoma underscores the need for detailed diagnostic analysis to inform prognosis and treatment strategies. There have been similar cases reported before, involving a 57-year-old male-patient (Sahetia et al. in Ind J Cancer 60:575–577, 2023). |
| format | Article |
| id | doaj-art-1ea13d44eb37425ebd2ba2eec025e3f8 |
| institution | Kabale University |
| issn | 2730-6011 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Springer |
| record_format | Article |
| series | Discover Oncology |
| spelling | doaj-art-1ea13d44eb37425ebd2ba2eec025e3f82025-02-09T12:43:35ZengSpringerDiscover Oncology2730-60112025-02-011611410.1007/s12672-025-01813-yPathological features and immunohistochemical characteristics of clear cell (glycogen-rich) urothelial carcinoma: a case report and systematic review of the literatureWeiming Wang0Baogang Zhang1Zhangli Wu2Chuanling Hou3Mengyao Li4Tianyi Zhang5Department of Pathology, Shaoxing People’s HospitalDepartment of Pathology, Shaoxing People’s HospitalDepartment of Nephrology Department, The Second Affiliated Hospital of Wannan Medical CollegeDepartment of Pathology, Shaoxing People’s HospitalDepartment of Pathology, Shaoxing People’s HospitalDepartment of Clinical Laboratory, Rizhao Hospital of Traditional Chinese MedicineAbstract Clear cell (glycogen-rich) urothelial carcinoma is an exceedingly rare variant of invasive urothelial carcinoma, distinguished by the presence of abundant cytoplasmic glycogen, which imparts a clear appearance to the tumor cells under histological examination. In this case report, the diagnosis was established through histopathological evaluation with hematoxylin and eosin (HE) staining, immunohistochemical analysis, and the identification of significant cytoplasmic glycogen accumulation. The patient, an 89-year-old male, was admitted on July 24, 2024, presenting with painless gross hematuria persisting for one week. Abdominal ultrasound and CT urography revealed a soft tissue mass on the right side of the bladder wall, measuring 30 × 30 mm, with a broad base connected to the bladder wall. The mass exhibited significant enhancement on contrast-enhanced scans, raising suspicion for malignancy. Microscopic examination revealed two distinct tumor cell morphologies: the conventional urothelial carcinoma pattern and a clear nest-like morphology, with the latter comprising over 70% of the tumor. Immunohistochemical staining for GATA-3, CK7, PAS, PAS-D, CAIX, PAX8, and RCC confirmed the diagnosis of clear cell (glycogen-rich) urothelial carcinoma. This rare variant of invasive urothelial carcinoma underscores the need for detailed diagnostic analysis to inform prognosis and treatment strategies. There have been similar cases reported before, involving a 57-year-old male-patient (Sahetia et al. in Ind J Cancer 60:575–577, 2023).https://doi.org/10.1007/s12672-025-01813-yClear cellUrothelial carcinomaRarePAS staining |
| spellingShingle | Weiming Wang Baogang Zhang Zhangli Wu Chuanling Hou Mengyao Li Tianyi Zhang Pathological features and immunohistochemical characteristics of clear cell (glycogen-rich) urothelial carcinoma: a case report and systematic review of the literature Discover Oncology Clear cell Urothelial carcinoma Rare PAS staining |
| title | Pathological features and immunohistochemical characteristics of clear cell (glycogen-rich) urothelial carcinoma: a case report and systematic review of the literature |
| title_full | Pathological features and immunohistochemical characteristics of clear cell (glycogen-rich) urothelial carcinoma: a case report and systematic review of the literature |
| title_fullStr | Pathological features and immunohistochemical characteristics of clear cell (glycogen-rich) urothelial carcinoma: a case report and systematic review of the literature |
| title_full_unstemmed | Pathological features and immunohistochemical characteristics of clear cell (glycogen-rich) urothelial carcinoma: a case report and systematic review of the literature |
| title_short | Pathological features and immunohistochemical characteristics of clear cell (glycogen-rich) urothelial carcinoma: a case report and systematic review of the literature |
| title_sort | pathological features and immunohistochemical characteristics of clear cell glycogen rich urothelial carcinoma a case report and systematic review of the literature |
| topic | Clear cell Urothelial carcinoma Rare PAS staining |
| url | https://doi.org/10.1007/s12672-025-01813-y |
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