Efficacy and safety of ustekinumab in the treatment of moderate to severe plaque psoriasis in Singapore
Introduction: Ustekinumab is a human monoclonal antibody that binds to the p40 subunit of both interleukin (IL)-12 and IL-23, and it is approved for the treatment of moderate to severe plaque psoriasis. In this study, we assessed the efficacy and safety of patients receiving ustekinumab for psoriasi...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer – Medknow Publications
2023-07-01
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| Series: | Singapore Medical Journal |
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| Online Access: | https://journals.lww.com/10.11622/smedj.2022029 |
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| author | Wai Sze Agnes Chan Yisheng Wong Hazel Hwee Boon Oon Colin Thiam Seng Theng Wei-Sheng Chong |
| author_facet | Wai Sze Agnes Chan Yisheng Wong Hazel Hwee Boon Oon Colin Thiam Seng Theng Wei-Sheng Chong |
| author_sort | Wai Sze Agnes Chan |
| collection | DOAJ |
| description | Introduction:
Ustekinumab is a human monoclonal antibody that binds to the p40 subunit of both interleukin (IL)-12 and IL-23, and it is approved for the treatment of moderate to severe plaque psoriasis. In this study, we assessed the efficacy and safety of patients receiving ustekinumab for psoriasis.
Methods:
This retrospective study included all adults with chronic plaque psoriasis who were prescribed ustekinumab in a tertiary dermatologic centre between December 2009 and December 2015. Efficacy end points included a proportion of patients achieving at least 50% and 75% improvement from baseline psoriasis area and severity index (PASI) and body surface area (BSA) at Weeks 4 and 16.
Results:
A total of 99 patients were prescribed ustekinumab; 69% of these were Chinese, followed by 15% Indians and 9% Malays. 31 patients had documented PASI scores and 55 patients had documented BSA improvements. In patients with recorded PASI scores, 29 (93.5%) of 31 patients achieved PASI 50, and 21 (67.7%) of 31 achieved PASI 75 at week 16. In patients with recorded BSA, 43 (78.2%) of 55 had at least 50% BSA improvement, and 31 (56.4%) of 55 achieved 75% BSA improvement at 16 weeks. Regarding safety, no patient experienced tuberculosis reactivation. A total of 11 (11%) of 99 patients had latent tuberculosis infection and were treated with prophylactic isoniazid. No patient experienced serious adverse events. No cardiovascular events, cutaneous malignancies or deaths were reported over six years.
Conclusion:
Ustekinumab is safe and efficacious in the treatment of patients with moderate to severe plaque psoriasis in a multiethnic Asian population. |
| format | Article |
| id | doaj-art-1f88f39fd8864b23b440c93651700b87 |
| institution | Kabale University |
| issn | 0037-5675 2737-5935 |
| language | English |
| publishDate | 2023-07-01 |
| publisher | Wolters Kluwer – Medknow Publications |
| record_format | Article |
| series | Singapore Medical Journal |
| spelling | doaj-art-1f88f39fd8864b23b440c93651700b872025-02-09T13:52:03ZengWolters Kluwer – Medknow PublicationsSingapore Medical Journal0037-56752737-59352023-07-0164743443810.11622/smedj.2022029Efficacy and safety of ustekinumab in the treatment of moderate to severe plaque psoriasis in SingaporeWai Sze Agnes ChanYisheng WongHazel Hwee Boon OonColin Thiam Seng ThengWei-Sheng ChongIntroduction: Ustekinumab is a human monoclonal antibody that binds to the p40 subunit of both interleukin (IL)-12 and IL-23, and it is approved for the treatment of moderate to severe plaque psoriasis. In this study, we assessed the efficacy and safety of patients receiving ustekinumab for psoriasis. Methods: This retrospective study included all adults with chronic plaque psoriasis who were prescribed ustekinumab in a tertiary dermatologic centre between December 2009 and December 2015. Efficacy end points included a proportion of patients achieving at least 50% and 75% improvement from baseline psoriasis area and severity index (PASI) and body surface area (BSA) at Weeks 4 and 16. Results: A total of 99 patients were prescribed ustekinumab; 69% of these were Chinese, followed by 15% Indians and 9% Malays. 31 patients had documented PASI scores and 55 patients had documented BSA improvements. In patients with recorded PASI scores, 29 (93.5%) of 31 patients achieved PASI 50, and 21 (67.7%) of 31 achieved PASI 75 at week 16. In patients with recorded BSA, 43 (78.2%) of 55 had at least 50% BSA improvement, and 31 (56.4%) of 55 achieved 75% BSA improvement at 16 weeks. Regarding safety, no patient experienced tuberculosis reactivation. A total of 11 (11%) of 99 patients had latent tuberculosis infection and were treated with prophylactic isoniazid. No patient experienced serious adverse events. No cardiovascular events, cutaneous malignancies or deaths were reported over six years. Conclusion: Ustekinumab is safe and efficacious in the treatment of patients with moderate to severe plaque psoriasis in a multiethnic Asian population.https://journals.lww.com/10.11622/smedj.2022029biologicpsoriasisustekinumab |
| spellingShingle | Wai Sze Agnes Chan Yisheng Wong Hazel Hwee Boon Oon Colin Thiam Seng Theng Wei-Sheng Chong Efficacy and safety of ustekinumab in the treatment of moderate to severe plaque psoriasis in Singapore Singapore Medical Journal biologic psoriasis ustekinumab |
| title | Efficacy and safety of ustekinumab in the treatment of moderate to severe plaque psoriasis in Singapore |
| title_full | Efficacy and safety of ustekinumab in the treatment of moderate to severe plaque psoriasis in Singapore |
| title_fullStr | Efficacy and safety of ustekinumab in the treatment of moderate to severe plaque psoriasis in Singapore |
| title_full_unstemmed | Efficacy and safety of ustekinumab in the treatment of moderate to severe plaque psoriasis in Singapore |
| title_short | Efficacy and safety of ustekinumab in the treatment of moderate to severe plaque psoriasis in Singapore |
| title_sort | efficacy and safety of ustekinumab in the treatment of moderate to severe plaque psoriasis in singapore |
| topic | biologic psoriasis ustekinumab |
| url | https://journals.lww.com/10.11622/smedj.2022029 |
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