More microinvasive foci in larger tumours of breast ductal carcinoma in situ
Introduction: Microinvasion (Mi) is often thought to be an interim stage between ductal carcinoma in situ (DCIS) and invasive ductal carcinoma. This study aimed to investigate the potential influence of Mi on survival and assess its correlations with clinicopathological parameters, prognosis and mol...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer – Medknow Publications
2023-08-01
|
| Series: | Singapore Medical Journal |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.11622/smedj.2022089 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1823861397354708992 |
|---|---|
| author | Xiao-Yang Chen Aye Aye Thike Johnathan Xiande Lim Boon Huat Bay Puay Hoon Tan |
| author_facet | Xiao-Yang Chen Aye Aye Thike Johnathan Xiande Lim Boon Huat Bay Puay Hoon Tan |
| author_sort | Xiao-Yang Chen |
| collection | DOAJ |
| description | Introduction:
Microinvasion (Mi) is often thought to be an interim stage between ductal carcinoma in situ (DCIS) and invasive ductal carcinoma. This study aimed to investigate the potential influence of Mi on survival and assess its correlations with clinicopathological parameters, prognosis and molecular markers.
Methods:
The number of Mi foci in a cohort of 66 DCIS-Mi cases was assessed from haematoxylin and eosin–stained sections. Disease-free survival, clinicopathological parameters and biomarker expression were correlated with the number of Mi foci.
Results:
Higher numbers of Mi foci were found in larger tumours (P = 0.031).
Conclusion:
Greater extent of DCIS is associated with multifocal Mi. |
| format | Article |
| id | doaj-art-2168586a3b4845bbaa68b7e98d471936 |
| institution | Kabale University |
| issn | 0037-5675 2737-5935 |
| language | English |
| publishDate | 2023-08-01 |
| publisher | Wolters Kluwer – Medknow Publications |
| record_format | Article |
| series | Singapore Medical Journal |
| spelling | doaj-art-2168586a3b4845bbaa68b7e98d4719362025-02-09T13:56:41ZengWolters Kluwer – Medknow PublicationsSingapore Medical Journal0037-56752737-59352023-08-0164849349610.11622/smedj.2022089More microinvasive foci in larger tumours of breast ductal carcinoma in situXiao-Yang ChenAye Aye ThikeJohnathan Xiande LimBoon Huat BayPuay Hoon TanIntroduction: Microinvasion (Mi) is often thought to be an interim stage between ductal carcinoma in situ (DCIS) and invasive ductal carcinoma. This study aimed to investigate the potential influence of Mi on survival and assess its correlations with clinicopathological parameters, prognosis and molecular markers. Methods: The number of Mi foci in a cohort of 66 DCIS-Mi cases was assessed from haematoxylin and eosin–stained sections. Disease-free survival, clinicopathological parameters and biomarker expression were correlated with the number of Mi foci. Results: Higher numbers of Mi foci were found in larger tumours (P = 0.031). Conclusion: Greater extent of DCIS is associated with multifocal Mi.https://journals.lww.com/10.11622/smedj.2022089dcisipsilateral invasive recurrencemicroinvasionmicroinvasive fociprogression |
| spellingShingle | Xiao-Yang Chen Aye Aye Thike Johnathan Xiande Lim Boon Huat Bay Puay Hoon Tan More microinvasive foci in larger tumours of breast ductal carcinoma in situ Singapore Medical Journal dcis ipsilateral invasive recurrence microinvasion microinvasive foci progression |
| title | More microinvasive foci in larger tumours of breast ductal carcinoma in situ |
| title_full | More microinvasive foci in larger tumours of breast ductal carcinoma in situ |
| title_fullStr | More microinvasive foci in larger tumours of breast ductal carcinoma in situ |
| title_full_unstemmed | More microinvasive foci in larger tumours of breast ductal carcinoma in situ |
| title_short | More microinvasive foci in larger tumours of breast ductal carcinoma in situ |
| title_sort | more microinvasive foci in larger tumours of breast ductal carcinoma in situ |
| topic | dcis ipsilateral invasive recurrence microinvasion microinvasive foci progression |
| url | https://journals.lww.com/10.11622/smedj.2022089 |
| work_keys_str_mv | AT xiaoyangchen moremicroinvasivefociinlargertumoursofbreastductalcarcinomainsitu AT ayeayethike moremicroinvasivefociinlargertumoursofbreastductalcarcinomainsitu AT johnathanxiandelim moremicroinvasivefociinlargertumoursofbreastductalcarcinomainsitu AT boonhuatbay moremicroinvasivefociinlargertumoursofbreastductalcarcinomainsitu AT puayhoontan moremicroinvasivefociinlargertumoursofbreastductalcarcinomainsitu |