Effect of Synthetic Bone Graft Substitutes in Management of Nonunion in Long Bones: A Case Series
Introduction: Treating nonunion is a major concern for any orthopedic surgeon. Preparation of autograft for use in nonunion itself is associated with various complications, starting from donor site morbidities to postoperative wound infections. To overcome these complications, an artificial substanc...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Jaypee Brothers Medical Publisher
2024-01-01
|
| Series: | Journal of Orthopedics and Joint Surgery |
| Subjects: | |
| Online Access: | https://www.jojs.in/doi/JOJS/pdf/10.5005/jojs-10079-1130 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1825206213688688640 |
|---|---|
| author | Muthamilselvan Kumanan Manikandan Navaneethakrishnapandian Mohamed Ibrahim |
| author_facet | Muthamilselvan Kumanan Manikandan Navaneethakrishnapandian Mohamed Ibrahim |
| author_sort | Muthamilselvan Kumanan |
| collection | DOAJ |
| description | Introduction: Treating nonunion is a major concern for any orthopedic surgeon. Preparation of autograft for use in nonunion itself is associated with various complications, starting from donor site morbidities to postoperative wound infections. To overcome these complications, an artificial substance that is biocompatible, which mimics all the properties of an autograft, may be an ideal thing for the management of nonunion. One such thing that was put forth in our study is “Synthetic Bone Graft.” All the pros and cons and their effectiveness in today's modern orthopedic management of nonunion are discussed below.
Aim: To evaluate the efficacy and outcome of synthetic bone grafting substances in the management of nonunion in long bones.
Materials and methods: This is a cross-sectional study. Patients with noninfected nonunion are selected. A total of 20 patients were treated with specific fracture fixation augmented with synthetic bone grafts and were followed for about 18 months in the Department of Orthopaedics, Tirunelveli Medical College Hospital, Tirunelveli, Tamil Nadu, India.
Results and discussion: In our study of 20 cases with nonunion of long bones, 90% of cases (18 cases out of 20 cases) showed clinical and radiological union among our case study. A bone substitute with the composition of tricalcium phosphate and calcium sulfate is used in our study. Functional and radiological outcomes of synthetic bone graft materials in the management of nonunion in long bones showed far better results compared to other bone graft materials. In the future, the use of these synthetic bone graft materials in bone regeneration under specific indications and with safety roles will simulate the normal bone formation cascade with reduced morbidity and cost in the long-term. |
| format | Article |
| id | doaj-art-21b024b84ccc4a40b0f97c9bc55c66a1 |
| institution | Kabale University |
| issn | 2582-7863 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Jaypee Brothers Medical Publisher |
| record_format | Article |
| series | Journal of Orthopedics and Joint Surgery |
| spelling | doaj-art-21b024b84ccc4a40b0f97c9bc55c66a12025-02-07T11:17:47ZengJaypee Brothers Medical PublisherJournal of Orthopedics and Joint Surgery2582-78632024-01-0161394310.5005/jojs-10079-11307Effect of Synthetic Bone Graft Substitutes in Management of Nonunion in Long Bones: A Case SeriesMuthamilselvan Kumanan0Manikandan Navaneethakrishnapandian1Mohamed Ibrahim2Department of Orthopaedics, Tirunelveli Medical College Hospital, Tirunelveli, Tamil Nadu, IndiaManikandan Navaneethakrishnapandian, Department of Orthopaedics, Tirunelveli Medical College Hospital, Tirunelveli, Tamil Nadu, India, Phone: +91 9443164800Department of Orthopaedics, Tirunelveli Medical College Hospital, Tirunelveli, Tamil Nadu, IndiaIntroduction: Treating nonunion is a major concern for any orthopedic surgeon. Preparation of autograft for use in nonunion itself is associated with various complications, starting from donor site morbidities to postoperative wound infections. To overcome these complications, an artificial substance that is biocompatible, which mimics all the properties of an autograft, may be an ideal thing for the management of nonunion. One such thing that was put forth in our study is “Synthetic Bone Graft.” All the pros and cons and their effectiveness in today's modern orthopedic management of nonunion are discussed below. Aim: To evaluate the efficacy and outcome of synthetic bone grafting substances in the management of nonunion in long bones. Materials and methods: This is a cross-sectional study. Patients with noninfected nonunion are selected. A total of 20 patients were treated with specific fracture fixation augmented with synthetic bone grafts and were followed for about 18 months in the Department of Orthopaedics, Tirunelveli Medical College Hospital, Tirunelveli, Tamil Nadu, India. Results and discussion: In our study of 20 cases with nonunion of long bones, 90% of cases (18 cases out of 20 cases) showed clinical and radiological union among our case study. A bone substitute with the composition of tricalcium phosphate and calcium sulfate is used in our study. Functional and radiological outcomes of synthetic bone graft materials in the management of nonunion in long bones showed far better results compared to other bone graft materials. In the future, the use of these synthetic bone graft materials in bone regeneration under specific indications and with safety roles will simulate the normal bone formation cascade with reduced morbidity and cost in the long-term.https://www.jojs.in/doi/JOJS/pdf/10.5005/jojs-10079-1130case reportbone graft substitutescalcium sulfatecalcium triphosphatesynthetic bone graft substitutes |
| spellingShingle | Muthamilselvan Kumanan Manikandan Navaneethakrishnapandian Mohamed Ibrahim Effect of Synthetic Bone Graft Substitutes in Management of Nonunion in Long Bones: A Case Series Journal of Orthopedics and Joint Surgery case report bone graft substitutes calcium sulfate calcium triphosphate synthetic bone graft substitutes |
| title | Effect of Synthetic Bone Graft Substitutes in Management of Nonunion in Long Bones: A Case Series |
| title_full | Effect of Synthetic Bone Graft Substitutes in Management of Nonunion in Long Bones: A Case Series |
| title_fullStr | Effect of Synthetic Bone Graft Substitutes in Management of Nonunion in Long Bones: A Case Series |
| title_full_unstemmed | Effect of Synthetic Bone Graft Substitutes in Management of Nonunion in Long Bones: A Case Series |
| title_short | Effect of Synthetic Bone Graft Substitutes in Management of Nonunion in Long Bones: A Case Series |
| title_sort | effect of synthetic bone graft substitutes in management of nonunion in long bones a case series |
| topic | case report bone graft substitutes calcium sulfate calcium triphosphate synthetic bone graft substitutes |
| url | https://www.jojs.in/doi/JOJS/pdf/10.5005/jojs-10079-1130 |
| work_keys_str_mv | AT muthamilselvankumanan effectofsyntheticbonegraftsubstitutesinmanagementofnonunioninlongbonesacaseseries AT manikandannavaneethakrishnapandian effectofsyntheticbonegraftsubstitutesinmanagementofnonunioninlongbonesacaseseries AT mohamedibrahim effectofsyntheticbonegraftsubstitutesinmanagementofnonunioninlongbonesacaseseries |