Enhancing magnetic hyperthermia: Investigating iron oxide nanoparticle coating and stability
Cancer treatment research focuses on overcoming the limitations of conventional treatment methods, especially in addressing treatment-resistant malignancies. Magnetic hyperthermia (MH) is an innovative approach that uses superparamagnetic iron oxide nanoparticles (SPIONs) to increase the temperature...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-01-01
|
| Series: | Next Nanotechnology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2949829525000105 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1825206851383328768 |
|---|---|
| author | Joana Santos Jorge Carvalho Silva Manuel A. Valente Tânia Vieira Paula I.P. Soares |
| author_facet | Joana Santos Jorge Carvalho Silva Manuel A. Valente Tânia Vieira Paula I.P. Soares |
| author_sort | Joana Santos |
| collection | DOAJ |
| description | Cancer treatment research focuses on overcoming the limitations of conventional treatment methods, especially in addressing treatment-resistant malignancies. Magnetic hyperthermia (MH) is an innovative approach that uses superparamagnetic iron oxide nanoparticles (SPIONs) to increase the temperature locally, triggering cancer cell death. However, challenges related to the SPIONs coating impact their stability and MH heating mechanism, hindering its clinical adoption. This work explores diverse SPIONs coating options - oleic acid (OA), dimercaptosuccinic acid (DMSA), and (3-aminopropyl)triethoxysilane (APTES), to improve SPIONS stability under storage while keeping their heating capacity. OA- and DMSA-coated SPIONs, both negatively charged NPs, exhibited similar behavior in protein corona formation and MH tests. The heating capacity of the three types of SPIONs was maintained after 1 month of storage; however, these values significantly decreased to about 60 % of the initial value after 6 months. APTES-coated SPIONs displayed higher protein corona formation, mainly related to the positively charged surface. Interaction studies with three cell lines (fibroblasts, melanoma, and macrophages) revealed enhanced internalization of APTES-coated SPIONs. Only APTES-coated SPIONs achieved therapeutic temperatures in MH assays, reducing melanoma cell viability significantly. The study underscores the importance of nanoparticle surface modifications and the complexity of factors influencing treatment efficacy. Further research is essential for a better understanding of the cell death mechanism induced by MH and for its clinical translation. |
| format | Article |
| id | doaj-art-2232ea80140b456f88233a0cdcb22e28 |
| institution | Kabale University |
| issn | 2949-8295 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Next Nanotechnology |
| spelling | doaj-art-2232ea80140b456f88233a0cdcb22e282025-02-07T04:48:37ZengElsevierNext Nanotechnology2949-82952025-01-017100141Enhancing magnetic hyperthermia: Investigating iron oxide nanoparticle coating and stabilityJoana Santos0Jorge Carvalho Silva1Manuel A. Valente2Tânia Vieira3Paula I.P. Soares4i3N/CENIMAT, Department of Materials Science, NOVA School of Science and Technology, NOVA University of Lisbon, Campus de Caparica, Caparica 2829-516, Portugal; i3N/CENIMAT, Department of Physics, NOVA School of Science and Technology, NOVA University of Lisbon, Campus de Caparica, Caparica 2829-516, Portugali3N/CENIMAT, Department of Physics, NOVA School of Science and Technology, NOVA University of Lisbon, Campus de Caparica, Caparica 2829-516, PortugalPhysics Department (i3N), University of Aveiro, Campus Universitário de Santiago, Aveiro, Portugali3N/CENIMAT, Department of Physics, NOVA School of Science and Technology, NOVA University of Lisbon, Campus de Caparica, Caparica 2829-516, Portugali3N/CENIMAT, Department of Materials Science, NOVA School of Science and Technology, NOVA University of Lisbon, Campus de Caparica, Caparica 2829-516, Portugal; Corresponding author.Cancer treatment research focuses on overcoming the limitations of conventional treatment methods, especially in addressing treatment-resistant malignancies. Magnetic hyperthermia (MH) is an innovative approach that uses superparamagnetic iron oxide nanoparticles (SPIONs) to increase the temperature locally, triggering cancer cell death. However, challenges related to the SPIONs coating impact their stability and MH heating mechanism, hindering its clinical adoption. This work explores diverse SPIONs coating options - oleic acid (OA), dimercaptosuccinic acid (DMSA), and (3-aminopropyl)triethoxysilane (APTES), to improve SPIONS stability under storage while keeping their heating capacity. OA- and DMSA-coated SPIONs, both negatively charged NPs, exhibited similar behavior in protein corona formation and MH tests. The heating capacity of the three types of SPIONs was maintained after 1 month of storage; however, these values significantly decreased to about 60 % of the initial value after 6 months. APTES-coated SPIONs displayed higher protein corona formation, mainly related to the positively charged surface. Interaction studies with three cell lines (fibroblasts, melanoma, and macrophages) revealed enhanced internalization of APTES-coated SPIONs. Only APTES-coated SPIONs achieved therapeutic temperatures in MH assays, reducing melanoma cell viability significantly. The study underscores the importance of nanoparticle surface modifications and the complexity of factors influencing treatment efficacy. Further research is essential for a better understanding of the cell death mechanism induced by MH and for its clinical translation.http://www.sciencedirect.com/science/article/pii/S2949829525000105Protein coronaSuperparamagnetic iron oxide nanoparticlesMagnetic hyperthermiaNanotechnologyStability |
| spellingShingle | Joana Santos Jorge Carvalho Silva Manuel A. Valente Tânia Vieira Paula I.P. Soares Enhancing magnetic hyperthermia: Investigating iron oxide nanoparticle coating and stability Next Nanotechnology Protein corona Superparamagnetic iron oxide nanoparticles Magnetic hyperthermia Nanotechnology Stability |
| title | Enhancing magnetic hyperthermia: Investigating iron oxide nanoparticle coating and stability |
| title_full | Enhancing magnetic hyperthermia: Investigating iron oxide nanoparticle coating and stability |
| title_fullStr | Enhancing magnetic hyperthermia: Investigating iron oxide nanoparticle coating and stability |
| title_full_unstemmed | Enhancing magnetic hyperthermia: Investigating iron oxide nanoparticle coating and stability |
| title_short | Enhancing magnetic hyperthermia: Investigating iron oxide nanoparticle coating and stability |
| title_sort | enhancing magnetic hyperthermia investigating iron oxide nanoparticle coating and stability |
| topic | Protein corona Superparamagnetic iron oxide nanoparticles Magnetic hyperthermia Nanotechnology Stability |
| url | http://www.sciencedirect.com/science/article/pii/S2949829525000105 |
| work_keys_str_mv | AT joanasantos enhancingmagnetichyperthermiainvestigatingironoxidenanoparticlecoatingandstability AT jorgecarvalhosilva enhancingmagnetichyperthermiainvestigatingironoxidenanoparticlecoatingandstability AT manuelavalente enhancingmagnetichyperthermiainvestigatingironoxidenanoparticlecoatingandstability AT taniavieira enhancingmagnetichyperthermiainvestigatingironoxidenanoparticlecoatingandstability AT paulaipsoares enhancingmagnetichyperthermiainvestigatingironoxidenanoparticlecoatingandstability |