Triglyceride-glucose index and mortality risks in Helicobacter pylori-infected patients: a national cohort study
Abstract Background While Helicobacter pylori (H. pylori) infection is associated with insulin resistance and higher mortality, research on insulin resistance indices and outcomes in H. pylori-infected patients is scarce. This study examines the association between the triglyceride-glucose (TyG) ind...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-02-01
|
| Series: | BMC Infectious Diseases |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12879-025-10556-8 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1825197574537084928 |
|---|---|
| author | Yue Cao Lingxiao Li Feipeng Qiu Weixing Wen Hao Zhang Yangxin Chen Xiaoyan Cai Yuli Huang |
| author_facet | Yue Cao Lingxiao Li Feipeng Qiu Weixing Wen Hao Zhang Yangxin Chen Xiaoyan Cai Yuli Huang |
| author_sort | Yue Cao |
| collection | DOAJ |
| description | Abstract Background While Helicobacter pylori (H. pylori) infection is associated with insulin resistance and higher mortality, research on insulin resistance indices and outcomes in H. pylori-infected patients is scarce. This study examines the association between the triglyceride-glucose (TyG) index, an insulin resistance marker, and all-cause and cardiovascular mortality in these patients. Methods This study analyzed NHANES 1999–2000 data to assess the association between the TyG index and all-cause and cardiovascular mortality in H. pylori-infected patients using weighted Cox models and restricted cubic spline analysis. Results Among 627 participants with a median follow-up of 20.8 years, 108 all-cause and 28 cardiovascular deaths occurred. Cox models showed that TyG was linked to a hazard ratio (HR) of 1.70 for all-cause mortality (95% CI: 1.23–2.34, P < 0.01) and an HR of 2.90 for cardiovascular mortality (95% CI: 1.91–4.42, P < 0.001). Restricted cubic spline analysis confirmed a linear relationship between the TyG index and both mortality risks. Stratified analyses showed that this relationship was significantly associated in most subgroups, but there was no significant interaction. Conclusion Higher TyG index is strongly linked to increased risks of both all-cause and cardiovascular mortality in H. pylori-infected patients. |
| format | Article |
| id | doaj-art-22528f161cbf4cf3ae119c5b2f3a84dd |
| institution | Kabale University |
| issn | 1471-2334 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Infectious Diseases |
| spelling | doaj-art-22528f161cbf4cf3ae119c5b2f3a84dd2025-02-09T12:14:38ZengBMCBMC Infectious Diseases1471-23342025-02-012511910.1186/s12879-025-10556-8Triglyceride-glucose index and mortality risks in Helicobacter pylori-infected patients: a national cohort studyYue Cao0Lingxiao Li1Feipeng Qiu2Weixing Wen3Hao Zhang4Yangxin Chen5Xiaoyan Cai6Yuli Huang7Department of Cardiology, Shunde Hospital, Southern Medical University (The First People’s Hospital of Shunde)Department of Cardiology, Shunde Hospital, Southern Medical University (The First People’s Hospital of Shunde)Department of Cardiology, Shunde Hospital, Southern Medical University (The First People’s Hospital of Shunde)Department of Cardiology, Shunde Hospital, Southern Medical University (The First People’s Hospital of Shunde)Department of Cardiology, Shunde Hospital, Southern Medical University (The First People’s Hospital of Shunde)Sun Yat-sen Memorial Hospital, Sun Yat-sen UniversityDepartment of Scientific Research and Education, Shunde Hospital, Southern Medical UniversityDepartment of Cardiology, Shunde Hospital, Southern Medical University (The First People’s Hospital of Shunde)Abstract Background While Helicobacter pylori (H. pylori) infection is associated with insulin resistance and higher mortality, research on insulin resistance indices and outcomes in H. pylori-infected patients is scarce. This study examines the association between the triglyceride-glucose (TyG) index, an insulin resistance marker, and all-cause and cardiovascular mortality in these patients. Methods This study analyzed NHANES 1999–2000 data to assess the association between the TyG index and all-cause and cardiovascular mortality in H. pylori-infected patients using weighted Cox models and restricted cubic spline analysis. Results Among 627 participants with a median follow-up of 20.8 years, 108 all-cause and 28 cardiovascular deaths occurred. Cox models showed that TyG was linked to a hazard ratio (HR) of 1.70 for all-cause mortality (95% CI: 1.23–2.34, P < 0.01) and an HR of 2.90 for cardiovascular mortality (95% CI: 1.91–4.42, P < 0.001). Restricted cubic spline analysis confirmed a linear relationship between the TyG index and both mortality risks. Stratified analyses showed that this relationship was significantly associated in most subgroups, but there was no significant interaction. Conclusion Higher TyG index is strongly linked to increased risks of both all-cause and cardiovascular mortality in H. pylori-infected patients.https://doi.org/10.1186/s12879-025-10556-8Helicobacter pyloriCardiovascular diseasesMortalityInsulin resistance |
| spellingShingle | Yue Cao Lingxiao Li Feipeng Qiu Weixing Wen Hao Zhang Yangxin Chen Xiaoyan Cai Yuli Huang Triglyceride-glucose index and mortality risks in Helicobacter pylori-infected patients: a national cohort study BMC Infectious Diseases Helicobacter pylori Cardiovascular diseases Mortality Insulin resistance |
| title | Triglyceride-glucose index and mortality risks in Helicobacter pylori-infected patients: a national cohort study |
| title_full | Triglyceride-glucose index and mortality risks in Helicobacter pylori-infected patients: a national cohort study |
| title_fullStr | Triglyceride-glucose index and mortality risks in Helicobacter pylori-infected patients: a national cohort study |
| title_full_unstemmed | Triglyceride-glucose index and mortality risks in Helicobacter pylori-infected patients: a national cohort study |
| title_short | Triglyceride-glucose index and mortality risks in Helicobacter pylori-infected patients: a national cohort study |
| title_sort | triglyceride glucose index and mortality risks in helicobacter pylori infected patients a national cohort study |
| topic | Helicobacter pylori Cardiovascular diseases Mortality Insulin resistance |
| url | https://doi.org/10.1186/s12879-025-10556-8 |
| work_keys_str_mv | AT yuecao triglycerideglucoseindexandmortalityrisksinhelicobacterpyloriinfectedpatientsanationalcohortstudy AT lingxiaoli triglycerideglucoseindexandmortalityrisksinhelicobacterpyloriinfectedpatientsanationalcohortstudy AT feipengqiu triglycerideglucoseindexandmortalityrisksinhelicobacterpyloriinfectedpatientsanationalcohortstudy AT weixingwen triglycerideglucoseindexandmortalityrisksinhelicobacterpyloriinfectedpatientsanationalcohortstudy AT haozhang triglycerideglucoseindexandmortalityrisksinhelicobacterpyloriinfectedpatientsanationalcohortstudy AT yangxinchen triglycerideglucoseindexandmortalityrisksinhelicobacterpyloriinfectedpatientsanationalcohortstudy AT xiaoyancai triglycerideglucoseindexandmortalityrisksinhelicobacterpyloriinfectedpatientsanationalcohortstudy AT yulihuang triglycerideglucoseindexandmortalityrisksinhelicobacterpyloriinfectedpatientsanationalcohortstudy |