Success Rates of Clomiphene Citrate and Recombinant Gonadotropin Cycles: A Single-Center Experience
Objective: This aim of this study is to assess the ovulation induction cycles based on clomiphene citrate and gonadotropin administration and specify the factors associated with successful outcomes. Study Design: This is a prospective study of 631 patients who underwent 917 ovulation induction cy...
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| Format: | Article |
| Language: | English |
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Medical Network
2020-03-01
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| Series: | Gynecology Obstetrics & Reproductive Medicine |
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| Online Access: | https://gorm.com.tr/index.php/GORM/article/view/978 |
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| author | Beril Gurlek Ali Sertac Batioglu Mine Kanat-Pektas Ibrahim Kale Ozgur Onal Nafiye Yilmaz-Karakas |
| author_facet | Beril Gurlek Ali Sertac Batioglu Mine Kanat-Pektas Ibrahim Kale Ozgur Onal Nafiye Yilmaz-Karakas |
| author_sort | Beril Gurlek |
| collection | DOAJ |
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Objective: This aim of this study is to assess the ovulation induction cycles based on clomiphene citrate and gonadotropin administration and specify the factors associated with successful outcomes.
Study Design: This is a prospective study of 631 patients who underwent 917 ovulation induction cycles. While clomiphene citrate was used in 680 cycles (74.2%) and recombinant follicle-stimulating hormone was administered in 237 cycles (25.8%).
Results: A total of 153 pregnancies were achieved in 917 ovulation induction cycles, indicating a clinical pregnancy rate of 16.7%. The ovulation induction cycles which ended up with clinical pregnancy had a significantly lower frequency of smoking (p=0.005), shorter infertility duration (p=0.001), higher basal luteinizing hormone (p=0.021) and lower basal progesterone (p=0.008) than unsuccessful cycles. The clomiphene citrate cycles which ended up with clinical pregnancy had a significantly lower frequency of smoking (p=0.011), shorter infertility duration (p=0.001) and lower basal progesterone (p=0.013) than the unsuccessful cycles. The recombinant follicle-stimulating hormone cycles which ended up with clinical pregnancy had a significantly higher basal luteinizing hormone (p=0.008) than the unsuccessful cycles. Basal luteinizing hormone and progesterone concentrations could significantly distinguish the patients who were able to conceive in ovulation induction cycles (p=0.021 and p=0.008, respectively).
Conclusions: Smoking, longer duration of infertility, and elevated basal progesterone are poor prognostic factors for clinical pregnancy in clomiphene citrate and recombinant follicle-stimulating hormone cycles.
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| format | Article |
| id | doaj-art-228cc0dc45e8453b999a9b68739a6851 |
| institution | Kabale University |
| issn | 1300-4751 2602-4918 |
| language | English |
| publishDate | 2020-03-01 |
| publisher | Medical Network |
| record_format | Article |
| series | Gynecology Obstetrics & Reproductive Medicine |
| spelling | doaj-art-228cc0dc45e8453b999a9b68739a68512025-02-11T21:27:20ZengMedical NetworkGynecology Obstetrics & Reproductive Medicine1300-47512602-49182020-03-0126110.21613/GORM.2019.978702Success Rates of Clomiphene Citrate and Recombinant Gonadotropin Cycles: A Single-Center ExperienceBeril Gurlek0Ali Sertac Batioglu1Mine Kanat-Pektas2Ibrahim Kale3Ozgur Onal4Nafiye Yilmaz-Karakas5Department of Obstetrics and Gynecology, Recep Tayyip Erdogan University School of Medicine, RizeDepartment of Obstetrics and Gynecology, Uşak University School of Medicine, UşakDepartment of Obstetrics and Gynecology, Afyon Kocatepe University Hospital, AfyonkarahisarDepartment of Obstetrics and Gynecology, Ümraniye Training and Research Hospital, İstanbulDepartment of Public Health, Süleyman Demirel University School of Medicine, IspartaDepartment of Reproductive Endocrinology, Zekai Tahir Burak Women’s Health and Research Hospital, Ankara Objective: This aim of this study is to assess the ovulation induction cycles based on clomiphene citrate and gonadotropin administration and specify the factors associated with successful outcomes. Study Design: This is a prospective study of 631 patients who underwent 917 ovulation induction cycles. While clomiphene citrate was used in 680 cycles (74.2%) and recombinant follicle-stimulating hormone was administered in 237 cycles (25.8%). Results: A total of 153 pregnancies were achieved in 917 ovulation induction cycles, indicating a clinical pregnancy rate of 16.7%. The ovulation induction cycles which ended up with clinical pregnancy had a significantly lower frequency of smoking (p=0.005), shorter infertility duration (p=0.001), higher basal luteinizing hormone (p=0.021) and lower basal progesterone (p=0.008) than unsuccessful cycles. The clomiphene citrate cycles which ended up with clinical pregnancy had a significantly lower frequency of smoking (p=0.011), shorter infertility duration (p=0.001) and lower basal progesterone (p=0.013) than the unsuccessful cycles. The recombinant follicle-stimulating hormone cycles which ended up with clinical pregnancy had a significantly higher basal luteinizing hormone (p=0.008) than the unsuccessful cycles. Basal luteinizing hormone and progesterone concentrations could significantly distinguish the patients who were able to conceive in ovulation induction cycles (p=0.021 and p=0.008, respectively). Conclusions: Smoking, longer duration of infertility, and elevated basal progesterone are poor prognostic factors for clinical pregnancy in clomiphene citrate and recombinant follicle-stimulating hormone cycles. https://gorm.com.tr/index.php/GORM/article/view/978ClomipheneFollicle-stimulating hormoneOvulation inductionPregnancyProgesterone |
| spellingShingle | Beril Gurlek Ali Sertac Batioglu Mine Kanat-Pektas Ibrahim Kale Ozgur Onal Nafiye Yilmaz-Karakas Success Rates of Clomiphene Citrate and Recombinant Gonadotropin Cycles: A Single-Center Experience Gynecology Obstetrics & Reproductive Medicine Clomiphene Follicle-stimulating hormone Ovulation induction Pregnancy Progesterone |
| title | Success Rates of Clomiphene Citrate and Recombinant Gonadotropin Cycles: A Single-Center Experience |
| title_full | Success Rates of Clomiphene Citrate and Recombinant Gonadotropin Cycles: A Single-Center Experience |
| title_fullStr | Success Rates of Clomiphene Citrate and Recombinant Gonadotropin Cycles: A Single-Center Experience |
| title_full_unstemmed | Success Rates of Clomiphene Citrate and Recombinant Gonadotropin Cycles: A Single-Center Experience |
| title_short | Success Rates of Clomiphene Citrate and Recombinant Gonadotropin Cycles: A Single-Center Experience |
| title_sort | success rates of clomiphene citrate and recombinant gonadotropin cycles a single center experience |
| topic | Clomiphene Follicle-stimulating hormone Ovulation induction Pregnancy Progesterone |
| url | https://gorm.com.tr/index.php/GORM/article/view/978 |
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