Novel cisplatin-magnetoliposome complex shows enhanced antitumor activity via Hyperthermia
Abstract There are several methods to improve cancer patient survival rates by inducing hyperthermia in tumor tissues, which involves raising their temperature above 41 °C. These methods utilize different energy sources to deliver heat to the target region, including light, microwaves or radiofreque...
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Nature Portfolio
2025-02-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-025-88533-z |
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| author | M. Carmen Jiménez-López Ana Carolina Moreno-Maldonado Natividad Martín-Morales Francisco O’Valle M. Ricardo Ibarra Gerardo F. Goya Ignacio J. Molina |
| author_facet | M. Carmen Jiménez-López Ana Carolina Moreno-Maldonado Natividad Martín-Morales Francisco O’Valle M. Ricardo Ibarra Gerardo F. Goya Ignacio J. Molina |
| author_sort | M. Carmen Jiménez-López |
| collection | DOAJ |
| description | Abstract There are several methods to improve cancer patient survival rates by inducing hyperthermia in tumor tissues, which involves raising their temperature above 41 °C. These methods utilize different energy sources to deliver heat to the target region, including light, microwaves or radiofrequency electromagnetic fields. We have developed a new, magnetically responsive nanocarrier, consisting of liposomes loaded with magnetic nanoparticles and cis-diamminedichloroplatinum (II) (CDDP), commonly known as Cisplatin. The resulting magnetoliposome (ML) is rapidly internalized by lung and pancreas tumor cell lines, stored in intracellular vesicles, and capable of inducing hyperthermia under magnetic fields. The ML has no significant toxicity both in vitro and in vivo and, most importantly, enhances cell death by apoptosis after magnetic hyperthermia. Remarkably, mice bearing induced lung tumors, treated with CDDP-loaded nanocarriers and subjected to an applied electromagnetic field, showed an improved survival rate over those treated with either soluble CDDP or hyperthermia alone. Therefore, our approach of magnetic hyperthermia plus CDDP-ML significantly enhances in vitro cell death and in vivo survival of treated animals. |
| format | Article |
| id | doaj-art-233bab1b3ad746fb88eb2ff5523e7098 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-233bab1b3ad746fb88eb2ff5523e70982025-02-09T12:29:28ZengNature PortfolioScientific Reports2045-23222025-02-0115111410.1038/s41598-025-88533-zNovel cisplatin-magnetoliposome complex shows enhanced antitumor activity via HyperthermiaM. Carmen Jiménez-López0Ana Carolina Moreno-Maldonado1Natividad Martín-Morales2Francisco O’Valle3M. Ricardo Ibarra4Gerardo F. Goya5Ignacio J. Molina6Institute of Biopathology and Regenerative Medicine, Center for Biomedical Research. Health Sciences Technology Park, University of GranadaInstitute of Nanoscience and Materials of Aragón, CSIC-University of ZaragozaInstitute of Biopathology and Regenerative Medicine, Center for Biomedical Research. Health Sciences Technology Park, University of GranadaInstitute of Biopathology and Regenerative Medicine, Center for Biomedical Research. Health Sciences Technology Park, University of GranadaInstitute of Nanoscience and Materials of Aragón, CSIC-University of ZaragozaInstitute of Nanoscience and Materials of Aragón, CSIC-University of ZaragozaInstitute of Biopathology and Regenerative Medicine, Center for Biomedical Research. Health Sciences Technology Park, University of GranadaAbstract There are several methods to improve cancer patient survival rates by inducing hyperthermia in tumor tissues, which involves raising their temperature above 41 °C. These methods utilize different energy sources to deliver heat to the target region, including light, microwaves or radiofrequency electromagnetic fields. We have developed a new, magnetically responsive nanocarrier, consisting of liposomes loaded with magnetic nanoparticles and cis-diamminedichloroplatinum (II) (CDDP), commonly known as Cisplatin. The resulting magnetoliposome (ML) is rapidly internalized by lung and pancreas tumor cell lines, stored in intracellular vesicles, and capable of inducing hyperthermia under magnetic fields. The ML has no significant toxicity both in vitro and in vivo and, most importantly, enhances cell death by apoptosis after magnetic hyperthermia. Remarkably, mice bearing induced lung tumors, treated with CDDP-loaded nanocarriers and subjected to an applied electromagnetic field, showed an improved survival rate over those treated with either soluble CDDP or hyperthermia alone. Therefore, our approach of magnetic hyperthermia plus CDDP-ML significantly enhances in vitro cell death and in vivo survival of treated animals.https://doi.org/10.1038/s41598-025-88533-zMagnetoliposomesMagnetic hyperthermiaCis-diamminedichloroplatinum (II)CDDPLung tumorPancreas tumor |
| spellingShingle | M. Carmen Jiménez-López Ana Carolina Moreno-Maldonado Natividad Martín-Morales Francisco O’Valle M. Ricardo Ibarra Gerardo F. Goya Ignacio J. Molina Novel cisplatin-magnetoliposome complex shows enhanced antitumor activity via Hyperthermia Scientific Reports Magnetoliposomes Magnetic hyperthermia Cis-diamminedichloroplatinum (II) CDDP Lung tumor Pancreas tumor |
| title | Novel cisplatin-magnetoliposome complex shows enhanced antitumor activity via Hyperthermia |
| title_full | Novel cisplatin-magnetoliposome complex shows enhanced antitumor activity via Hyperthermia |
| title_fullStr | Novel cisplatin-magnetoliposome complex shows enhanced antitumor activity via Hyperthermia |
| title_full_unstemmed | Novel cisplatin-magnetoliposome complex shows enhanced antitumor activity via Hyperthermia |
| title_short | Novel cisplatin-magnetoliposome complex shows enhanced antitumor activity via Hyperthermia |
| title_sort | novel cisplatin magnetoliposome complex shows enhanced antitumor activity via hyperthermia |
| topic | Magnetoliposomes Magnetic hyperthermia Cis-diamminedichloroplatinum (II) CDDP Lung tumor Pancreas tumor |
| url | https://doi.org/10.1038/s41598-025-88533-z |
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