Histological risk score and its role in predicting recurrence in early-stage oral squamous cell carcinomas
Context: Oral squamous cell carcinoma (OSCC) comprises more than 90% of oral cancers and is the most common carcinoma affecting the oral cavity. Early stage T1/T2 OSCC have a heterogeneous prognosis and a significant number of patients develop loco regional recurrence (LRR) and have reduced disease...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2023-07-01
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| Series: | Indian Journal of Pathology and Microbiology |
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| Online Access: | https://journals.lww.com/10.4103/ijpm.ijpm_514_21 |
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| author | Daphne Fonseca Rashmi Khemani Mohan K. Pasam Ravindranath Tagore B. Vishal Rao Suseela Kodandapani Chandrasekhara Rao K. V. V. N. Raju T Subramanyeshwar Rao |
| author_facet | Daphne Fonseca Rashmi Khemani Mohan K. Pasam Ravindranath Tagore B. Vishal Rao Suseela Kodandapani Chandrasekhara Rao K. V. V. N. Raju T Subramanyeshwar Rao |
| author_sort | Daphne Fonseca |
| collection | DOAJ |
| description | Context:
Oral squamous cell carcinoma (OSCC) comprises more than 90% of oral cancers and is the most common carcinoma affecting the oral cavity. Early stage T1/T2 OSCC have a heterogeneous prognosis and a significant number of patients develop loco regional recurrence (LRR) and have reduced disease free survival (DFS) with increased disease related mortality.
Aims and Objectives:
To assess the impact of the three parameters used in Brandwein-Gensler risk model along with lympho-vascular invasion (LVI), depth of invasion (DOI) and lymph node metastases in predicting LRR in early stage OSCC.
Materials and Methods:
This was a retrospective study on early stage T1/2 OSCC patients over a period of 2 years who received treatment by surgical resection and had follow-up data. LRR was assessed based on recurrence of OSCC at the initial site or in regional lymph nodes.
Results:
Out of 1135 OSCC cases during our study period a total of 207 cases befitted our inclusion criteria. Recurrence was noted in 113 (54.6%) cases. Univariate analysis identified LVI (P < 0.00001), DOI (P < 0.00001), nodal involvement (P < 0.00001), worst pattern of invasion (WPOI) (P < 0.00001), lymphocytic host response (LHR) (P = 0.004), perineural invasion (PNI) (P = 0.012) as strong statistically significant risk factors for LRR.
Conclusion:
Adequate assessment of simple parameters on routine H and E by incorporating Brandwein-Gensler histological risk scoring model at the initial presentation can help prognosticate and predict LRR and select patients for post-surgical adjuvant therapy. |
| format | Article |
| id | doaj-art-24254bb1c074469696a7ffa4e60b0d9a |
| institution | Kabale University |
| issn | 0377-4929 |
| language | English |
| publishDate | 2023-07-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Pathology and Microbiology |
| spelling | doaj-art-24254bb1c074469696a7ffa4e60b0d9a2025-02-07T13:29:41ZengWolters Kluwer Medknow PublicationsIndian Journal of Pathology and Microbiology0377-49292023-07-0166344444810.4103/ijpm.ijpm_514_21Histological risk score and its role in predicting recurrence in early-stage oral squamous cell carcinomasDaphne FonsecaRashmi KhemaniMohan K. PasamRavindranath TagoreB. Vishal RaoSuseela KodandapaniChandrasekhara RaoK. V. V. N. RajuT Subramanyeshwar RaoContext: Oral squamous cell carcinoma (OSCC) comprises more than 90% of oral cancers and is the most common carcinoma affecting the oral cavity. Early stage T1/T2 OSCC have a heterogeneous prognosis and a significant number of patients develop loco regional recurrence (LRR) and have reduced disease free survival (DFS) with increased disease related mortality. Aims and Objectives: To assess the impact of the three parameters used in Brandwein-Gensler risk model along with lympho-vascular invasion (LVI), depth of invasion (DOI) and lymph node metastases in predicting LRR in early stage OSCC. Materials and Methods: This was a retrospective study on early stage T1/2 OSCC patients over a period of 2 years who received treatment by surgical resection and had follow-up data. LRR was assessed based on recurrence of OSCC at the initial site or in regional lymph nodes. Results: Out of 1135 OSCC cases during our study period a total of 207 cases befitted our inclusion criteria. Recurrence was noted in 113 (54.6%) cases. Univariate analysis identified LVI (P < 0.00001), DOI (P < 0.00001), nodal involvement (P < 0.00001), worst pattern of invasion (WPOI) (P < 0.00001), lymphocytic host response (LHR) (P = 0.004), perineural invasion (PNI) (P = 0.012) as strong statistically significant risk factors for LRR. Conclusion: Adequate assessment of simple parameters on routine H and E by incorporating Brandwein-Gensler histological risk scoring model at the initial presentation can help prognosticate and predict LRR and select patients for post-surgical adjuvant therapy.https://journals.lww.com/10.4103/ijpm.ijpm_514_21histological risk scoreoralsquamous cell carcinoma |
| spellingShingle | Daphne Fonseca Rashmi Khemani Mohan K. Pasam Ravindranath Tagore B. Vishal Rao Suseela Kodandapani Chandrasekhara Rao K. V. V. N. Raju T Subramanyeshwar Rao Histological risk score and its role in predicting recurrence in early-stage oral squamous cell carcinomas Indian Journal of Pathology and Microbiology histological risk score oral squamous cell carcinoma |
| title | Histological risk score and its role in predicting recurrence in early-stage oral squamous cell carcinomas |
| title_full | Histological risk score and its role in predicting recurrence in early-stage oral squamous cell carcinomas |
| title_fullStr | Histological risk score and its role in predicting recurrence in early-stage oral squamous cell carcinomas |
| title_full_unstemmed | Histological risk score and its role in predicting recurrence in early-stage oral squamous cell carcinomas |
| title_short | Histological risk score and its role in predicting recurrence in early-stage oral squamous cell carcinomas |
| title_sort | histological risk score and its role in predicting recurrence in early stage oral squamous cell carcinomas |
| topic | histological risk score oral squamous cell carcinoma |
| url | https://journals.lww.com/10.4103/ijpm.ijpm_514_21 |
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