Multicenter study for CH-VAD as a fully magnetically levitated left ventricular assist device
Summary: The CH-VAD is a fully magnetically levitated left ventricular assist device (LVAD) designed for optimized hemocompatibility. This study evaluates the clinical outcomes of 77 patients implanted with the CH-VAD across seven centers in China from June 2022 to June 2024. Patients had a mean age...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-02-01
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| Series: | iScience |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004225000239 |
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| author | Yifan Lu Shuanglei Zhao Jie Han Qiang Lv Xin Du Zhengdong Hua Keli Huang Zhenwei Ge Xiaoning Sun Dan Zhu Yongfeng Shao Hongjia Zhang Ming Gong |
| author_facet | Yifan Lu Shuanglei Zhao Jie Han Qiang Lv Xin Du Zhengdong Hua Keli Huang Zhenwei Ge Xiaoning Sun Dan Zhu Yongfeng Shao Hongjia Zhang Ming Gong |
| author_sort | Yifan Lu |
| collection | DOAJ |
| description | Summary: The CH-VAD is a fully magnetically levitated left ventricular assist device (LVAD) designed for optimized hemocompatibility. This study evaluates the clinical outcomes of 77 patients implanted with the CH-VAD across seven centers in China from June 2022 to June 2024. Patients had a mean age of 57.5 years, primarily classified as INTERMACS 2 or 3, with dilated and ischemic cardiomyopathy as the main causes of heart failure (HF). The study reported a 91.6% survival rate at both 6-month and 1-year follow-ups, aligning with international LVAD outcomes. Key adverse events were infrequent, including low rates of right HF, reoperation for bleeding, and driveline infection. Importantly, no pump thrombosis or device failures were noted. The results suggest that the CH-VAD is a reliable and effective long-term mechanical circulatory support option for end-stage HF patients in China, warranting further studies for long-term efficacy evaluation. |
| format | Article |
| id | doaj-art-25722c4d01af4f3fb66813de3e1fa0b0 |
| institution | Kabale University |
| issn | 2589-0042 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj-art-25722c4d01af4f3fb66813de3e1fa0b02025-02-09T05:00:58ZengElsevieriScience2589-00422025-02-01282111764Multicenter study for CH-VAD as a fully magnetically levitated left ventricular assist deviceYifan Lu0Shuanglei Zhao1Jie Han2Qiang Lv3Xin Du4Zhengdong Hua5Keli Huang6Zhenwei Ge7Xiaoning Sun8Dan Zhu9Yongfeng Shao10Hongjia Zhang11Ming Gong12Heart Failure and Valve Surgery Center, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, ChinaHeart Failure and Valve Surgery Center, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, ChinaHeart Failure and Valve Surgery Center, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, ChinaDepartment of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, ChinaDepartment of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, ChinaDepartment of Cardiac Surgery, Asia Heart Hospital, Wuhan 430010, ChinaDepartment of Cardiac Surgery, Sichuan Provincial People’s Hospital, Chengdu 610072, ChinaDepartment of Cardiovascular Surgery, Henan Provincial Chest Hospital, Zhengzhou 450003, ChinaDepartment of Cardiac Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, ChinaDepartment of Cardiovascular Surgery, Shanghai Chest Hospital, Shanghai 200030, ChinaDepartment of Cardiovascular Surgery, Jiangsu Provincial People’s Hospital, Nanjing 212028, ChinaHeart Failure and Valve Surgery Center, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China; Corresponding authorHeart Failure and Valve Surgery Center, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China; Corresponding authorSummary: The CH-VAD is a fully magnetically levitated left ventricular assist device (LVAD) designed for optimized hemocompatibility. This study evaluates the clinical outcomes of 77 patients implanted with the CH-VAD across seven centers in China from June 2022 to June 2024. Patients had a mean age of 57.5 years, primarily classified as INTERMACS 2 or 3, with dilated and ischemic cardiomyopathy as the main causes of heart failure (HF). The study reported a 91.6% survival rate at both 6-month and 1-year follow-ups, aligning with international LVAD outcomes. Key adverse events were infrequent, including low rates of right HF, reoperation for bleeding, and driveline infection. Importantly, no pump thrombosis or device failures were noted. The results suggest that the CH-VAD is a reliable and effective long-term mechanical circulatory support option for end-stage HF patients in China, warranting further studies for long-term efficacy evaluation.http://www.sciencedirect.com/science/article/pii/S2589004225000239Health sciencesNatural sciencesApplied sciences |
| spellingShingle | Yifan Lu Shuanglei Zhao Jie Han Qiang Lv Xin Du Zhengdong Hua Keli Huang Zhenwei Ge Xiaoning Sun Dan Zhu Yongfeng Shao Hongjia Zhang Ming Gong Multicenter study for CH-VAD as a fully magnetically levitated left ventricular assist device iScience Health sciences Natural sciences Applied sciences |
| title | Multicenter study for CH-VAD as a fully magnetically levitated left ventricular assist device |
| title_full | Multicenter study for CH-VAD as a fully magnetically levitated left ventricular assist device |
| title_fullStr | Multicenter study for CH-VAD as a fully magnetically levitated left ventricular assist device |
| title_full_unstemmed | Multicenter study for CH-VAD as a fully magnetically levitated left ventricular assist device |
| title_short | Multicenter study for CH-VAD as a fully magnetically levitated left ventricular assist device |
| title_sort | multicenter study for ch vad as a fully magnetically levitated left ventricular assist device |
| topic | Health sciences Natural sciences Applied sciences |
| url | http://www.sciencedirect.com/science/article/pii/S2589004225000239 |
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