Compensatory increase in oxygen extraction fraction is associated with age-related cerebrovascular disease
Cerebrovascular disease is an important contributor to dementia with reductions in cerebral blood flow (CBF) potentially compromising oxygen supply. In early stages, reduced CBF may be associated with a compensatory increase in oxygen extraction fraction (OEF) to maintain the cerebral metabolic rate...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-01-01
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| Series: | NeuroImage: Clinical |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213158225000166 |
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| author | John McFadden Julian Matthews Lauren Scott Karl Herholz Ben Dickie Hamied Haroon Oliver Sparasci Saadat Ahmed Natalia Kyrtata Geoffrey J.M. Parker Hedley C.A. Emsley Joel Handley Maélène Lohezic Laura M. Parkes |
| author_facet | John McFadden Julian Matthews Lauren Scott Karl Herholz Ben Dickie Hamied Haroon Oliver Sparasci Saadat Ahmed Natalia Kyrtata Geoffrey J.M. Parker Hedley C.A. Emsley Joel Handley Maélène Lohezic Laura M. Parkes |
| author_sort | John McFadden |
| collection | DOAJ |
| description | Cerebrovascular disease is an important contributor to dementia with reductions in cerebral blood flow (CBF) potentially compromising oxygen supply. In early stages, reduced CBF may be associated with a compensatory increase in oxygen extraction fraction (OEF) to maintain the cerebral metabolic rate of oxygen consumption (CMRO2). We used a simultaneous PET-MRI protocol to measure OEF, CBF, CMRO2, and arterial transit time (ATT) in elderly people (n = 24, age 69.6 ± 5.3 years) with a range of vascular disease risk (QRisk 18.7 ± 10.8 %) and cognitive abilities (MoCA scores 26.7 ± 3.4) to determine if a) vascular disease risk (parameterised with QRisk2 score) is associated with altered CBF, ATT, OEF and CMRO2, b) if impaired blood supply and increasing transit times are associated with elevated OEF and c) if these physiological measures are associated with impaired cognition. ATT rose by 132 ms per 10 point increase in QRisk and there was a trend for reduced CBF. Compensatory increases in OEF occurred in association with modified ATT and CBF, preserving CMRO2. There was no regional variation to these relationships. Cognitive impairment was associated with prolonged ATT. These findings demonstrate the potential use of multi-delay time ASL and Quantitative Susceptibility Mapping for the early detection of cerebrovascular changes and provide evidence for compensatory increases in oxygen extraction in the presence of reduced blood flow. |
| format | Article |
| id | doaj-art-2572792eb5f64e4eb5f64075f81e4f31 |
| institution | Kabale University |
| issn | 2213-1582 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage: Clinical |
| spelling | doaj-art-2572792eb5f64e4eb5f64075f81e4f312025-02-08T05:00:23ZengElsevierNeuroImage: Clinical2213-15822025-01-0145103746Compensatory increase in oxygen extraction fraction is associated with age-related cerebrovascular diseaseJohn McFadden0Julian Matthews1Lauren Scott2Karl Herholz3Ben Dickie4Hamied Haroon5Oliver Sparasci6Saadat Ahmed7Natalia Kyrtata8Geoffrey J.M. Parker9Hedley C.A. Emsley10Joel Handley11Maélène Lohezic12Laura M. Parkes13Division of Psychology, Communication and Human Neuroscience, School of Health Sciences Faculty of Biology, Medicine, and Health the University of Manchester UKDivision of Psychology, Communication and Human Neuroscience, School of Health Sciences Faculty of Biology, Medicine, and Health the University of Manchester UKDivision of Psychology, Communication and Human Neuroscience, School of Health Sciences Faculty of Biology, Medicine, and Health the University of Manchester UKDivision of Psychology, Communication and Human Neuroscience, School of Health Sciences Faculty of Biology, Medicine, and Health the University of Manchester UKDivision of Informatics, Imaging and Data Science, School of Health Sciences Manchester UKDivision of Psychology, Communication and Human Neuroscience, School of Health Sciences Faculty of Biology, Medicine, and Health the University of Manchester UKDivision of Psychology, Communication and Human Neuroscience, School of Health Sciences Faculty of Biology, Medicine, and Health the University of Manchester UKDivision of Psychology, Communication and Human Neuroscience, School of Health Sciences Faculty of Biology, Medicine, and Health the University of Manchester UKDivision of Psychology, Communication and Human Neuroscience, School of Health Sciences Faculty of Biology, Medicine, and Health the University of Manchester UK; University Hospital of Morecambe Bay NHS Foundation Trust Lancaster UKBioxydyn Limited Manchester UK; Centre for Medical Image Computing Department of Medical Physics & Biomedical Engineering and Department of Neuroinflammation University College London London UKDivision of Psychology, Communication and Human Neuroscience, School of Health Sciences Faculty of Biology, Medicine, and Health the University of Manchester UK; Lancaster Medical School Lancaster University Lancaster UK; Department of Neurology Lancashire Teaching Hospitals NHS Foundation Trust Preston UKDepartment of Neurology Lancashire Teaching Hospitals NHS Foundation Trust Preston UKApplications & Workflow GE Healthcare Manchester UKDivision of Psychology, Communication and Human Neuroscience, School of Health Sciences Faculty of Biology, Medicine, and Health the University of Manchester UK; Geoffrey Jefferson Brain Research Centre Manchester Academic Health Science Centre Manchester UK; Corresponding author at: University of Manchester, Oxford Rd, Manchester, M13 9GB, UK.Cerebrovascular disease is an important contributor to dementia with reductions in cerebral blood flow (CBF) potentially compromising oxygen supply. In early stages, reduced CBF may be associated with a compensatory increase in oxygen extraction fraction (OEF) to maintain the cerebral metabolic rate of oxygen consumption (CMRO2). We used a simultaneous PET-MRI protocol to measure OEF, CBF, CMRO2, and arterial transit time (ATT) in elderly people (n = 24, age 69.6 ± 5.3 years) with a range of vascular disease risk (QRisk 18.7 ± 10.8 %) and cognitive abilities (MoCA scores 26.7 ± 3.4) to determine if a) vascular disease risk (parameterised with QRisk2 score) is associated with altered CBF, ATT, OEF and CMRO2, b) if impaired blood supply and increasing transit times are associated with elevated OEF and c) if these physiological measures are associated with impaired cognition. ATT rose by 132 ms per 10 point increase in QRisk and there was a trend for reduced CBF. Compensatory increases in OEF occurred in association with modified ATT and CBF, preserving CMRO2. There was no regional variation to these relationships. Cognitive impairment was associated with prolonged ATT. These findings demonstrate the potential use of multi-delay time ASL and Quantitative Susceptibility Mapping for the early detection of cerebrovascular changes and provide evidence for compensatory increases in oxygen extraction in the presence of reduced blood flow.http://www.sciencedirect.com/science/article/pii/S2213158225000166OEFQSMCBFCerebrovascular diseaseCognitive impairmentMulti-PLD ASL |
| spellingShingle | John McFadden Julian Matthews Lauren Scott Karl Herholz Ben Dickie Hamied Haroon Oliver Sparasci Saadat Ahmed Natalia Kyrtata Geoffrey J.M. Parker Hedley C.A. Emsley Joel Handley Maélène Lohezic Laura M. Parkes Compensatory increase in oxygen extraction fraction is associated with age-related cerebrovascular disease NeuroImage: Clinical OEF QSM CBF Cerebrovascular disease Cognitive impairment Multi-PLD ASL |
| title | Compensatory increase in oxygen extraction fraction is associated with age-related cerebrovascular disease |
| title_full | Compensatory increase in oxygen extraction fraction is associated with age-related cerebrovascular disease |
| title_fullStr | Compensatory increase in oxygen extraction fraction is associated with age-related cerebrovascular disease |
| title_full_unstemmed | Compensatory increase in oxygen extraction fraction is associated with age-related cerebrovascular disease |
| title_short | Compensatory increase in oxygen extraction fraction is associated with age-related cerebrovascular disease |
| title_sort | compensatory increase in oxygen extraction fraction is associated with age related cerebrovascular disease |
| topic | OEF QSM CBF Cerebrovascular disease Cognitive impairment Multi-PLD ASL |
| url | http://www.sciencedirect.com/science/article/pii/S2213158225000166 |
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