NLRP3 Inflammasome Activation Is Involved in Geniposide-Induced Hepatotoxicity
Conclusions: Our findings collectively elucidate that geniposide induces hepatotoxicity by triggering NLRP3 inflammasome signaling. Inhibition of the inflammasome presents a promising novel therapeutic target for mitigating geniposide-induced hepatotoxicity.
Saved in:
Main Authors: | Yixuan Liu, Baoyue Liu, Mingzhu Shi, Tianxiang Ye, Huifang Li |
---|---|
Format: | Article |
Language: | English |
Published: |
Wiley
2025-01-01
|
Series: | Mediators of Inflammation |
Online Access: | http://dx.doi.org/10.1155/mi/4112856 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
-
α-amanitin induces hepatotoxicity via PPAR-γ inhibition and NLRP3 inflammasome activation
by: Haowei Wang, et al.
Published: (2025-01-01) -
Metformin Ameliorates Ulcerative Colitis Through Inhibiting NLRP3 Inflammasome Activation
by: Cao R, et al.
Published: (2025-02-01) -
Verbascoside Inhibits the Activation of NLRP3 Inflammasome and Improves BV-2 Cell Inflammatory Damage
by: Wenjing HUANG, et al.
Published: (2025-02-01) -
Global Research Trends and Focus on the Link Between Heart Failure and NLRP3 Inflammasome: A Bibliometric Analysis From 2010 to 2024
by: Lian Y, et al.
Published: (2025-02-01) -
VANGL2 alleviates inflammatory bowel disease by recruiting the ubiquitin ligase MARCH8 to limit NLRP3 inflammasome activation through OPTN-mediated selective autophagy.
by: Huaji Jiang, et al.
Published: (2025-02-01)